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105 (0,084s) •

Project

Vascular reactivity in pulmonary hypertension (GA13-01710S)

Chronic and intermittent lung hypoxia causes hypoxic pulmonary hypertension of hypoxic pulmonary hypertension is hypoxia – induced tissue injury to pulmonary of pathologic stimulus (lung disease, ventilation hypoxia) and re...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2017
    • •
  • 8 709 tis. Kč
    • •
  • 8 709 tis. Kč
    • •
  • GA ČR
Project

Recovery from chonic lung hypoxia and effects of hypoxia in placenta. Pathophysiological basis for therapy. (GA305/08/0108)

Chronic hypoxia results in changes of vasculature of organs responsible for oxygen uptake ? the lung and placenta, which are reversible on return to normal oxygenation. The changes in pulmonary circulation complicate course of respiratory an...

ED - Fyziologie

  • 2008 - 2012
    • •
  • 9 580 tis. Kč
    • •
  • 9 580 tis. Kč
    • •
  • GA ČR
Project

The effect of neonatal hypoxia on the resistance of the adult myocardium to oxygen deficiency. (ND7607)

Myocardium exposed to chronic hypoxia in the early neonatal period can show different functional and mechanical properties in adulthood compared with myocardium not affected with hypoxia, particularly in a sense of ischemic damage. ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2003 - 2005
    • •
  • 2 094 tis. Kč
    • •
  • 2 089 tis. Kč
    • •
  • MZ
Project

The relationship between intrapartum fetal pulse oximetry,the CTG diagnosis of fetal hypoxia and the perinatal indicators of the state of the newborn (NK5911)

The aim the project is the improvement in the diagnosis of the intrauterine fetal hypoxia in the course of the 1 and 2 stages of labor by means of the evaluation of the fetal oxygen saturation by intrapartum fetal pulse oximetry and thus low...

FK - Gynekologie a porodnictví

  • 2000 - 2002
    • •
  • 1 523 tis. Kč
    • •
  • 1 504 tis. Kč
    • •
  • MZ
Project

Role of the oxygen radical stress in hypoxic pulmonary hypertension (LD14068)

To identify the participation of hypoxia-induced release of oxygen radicals in pathogenesis of hypoxic pulmonary hypertension. The development, effect of gender, changes of vascular reactivity. Role of NOS uncoupling. Hypoxia induce...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2014 - 2016
    • •
  • 2 511 tis. Kč
    • •
  • 2 085 tis. Kč
    • •
  • MŠMT
Project

Anterior eye segment hypoxia and post-hypoxic injury. The role of oxidative stress. Attempts at the development of effective therapies. (GA304/06/1379)

Anterior eye segment hypoxia and post-hypoxic injury after reoxygenation is dangerous to the eye from the development of severe ocular lesions leading to the partial or total loss of vision. Cellular hypoxia may result from either r...

FF - ORL, oftalmologie, stomatologie

  • 2006 - 2008
    • •
  • 4 991 tis. Kč
    • •
  • 4 991 tis. Kč
    • •
  • GA ČR
Project

Role of hypoxia-inducible factor 1 alpha in development of neural stem cell population in mouse (GJ15-13443Y)

(stemness) while avoid uncontrolled growth or proliferation. Low oxygen supply (hypoxia maintenance. Hypoxia inducible factors (HIF) are well described regulators of adaptation to hypoxia and recent studies suggest their r...

ED - Fyziologie

  • 2015 - 2019
    • •
  • 4 285 tis. Kč
    • •
  • 4 285 tis. Kč
    • •
  • GA ČR
Project

The prediction of an acute intrapartum fetal hypoxia in preterm labor and high risk pregrancies by means of the analysis of the ST segment of fetal ECG curve. (NH7660)

The aim of the project is the development of an exact algorythm of the diagnosis of an acute intrapartum fetal hypoxia by means of the analysis of the ST segment of the ecg fetal curve during preterm delivery and the delivery of a high risk ...

FK - Gynekologie a porodnictví

  • 2003 - 2005
    • •
  • 1 830 tis. Kč
    • •
  • 1 646 tis. Kč
    • •
  • MZ
Project

Cardioprotective mechanisms of chronic intermittent and sustained hypoxia role of reoxygenation. (GA305/07/0875)

Myocardial injury induced by acute ischemia/reperfusion insult can be substantially reduced by preceding adaptation to chronic intermittent hypoxia. This project reoxygenation, rather than hypoxia per se, is a crucial factor, which ...

ED - Fyziologie

  • 2007 - 2009
    • •
  • 3 089 tis. Kč
    • •
  • 3 089 tis. Kč
    • •
  • GA ČR
Project

Dynamics and mechanisms of the chronic hypoxia-induced alterations in pulmonary and placental circulations (GA305/05/0672)

, such as chronic hypoxia, have never been compared and are poorly understood. Chronic hypoxic responsible for individual variability in PHT, specifically perinatal hypoxia, will also be studied. As the main cause of perinatal h...

ED - Fyziologie

  • 2005 - 2007
    • •
  • 5 720 tis. Kč
    • •
  • 5 589 tis. Kč
    • •
  • GA ČR
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