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5 395 (0,081s) •

Project

Sensing of HIV-1 by plasmacytoid dendritic cells dichotomy of immunoreceptor signaling (GA14-32547S)

/inhibitory immunoreceptors of pDCs, BDCA-2 and DCIR, inhibits IFN-I production. Our of TLR7 and of protein kinases SYK and MEK involved in BDCA-2 and DCIR signaling, we......

EE - Mikrobiologie, virologie

  • 2014 - 2018
    • •
  • 6 397 tis. Kč
    • •
  • 6 397 tis. Kč
    • •
  • GA ČR
Project

Impact of the digestion and absorption processes on the final biological activity of diet phytonutrients real health added-value (8X20023)

1. Evaluating the digestion and absorption processes of phytonutrients before reaching the targeted cells (such as ovarian cells, mononuclear and dendritic cells). 2. In vitro testing of selected phytonutrients from the group of polyphenols,...

Cell biology

  • 2020 - 2022
    • •
  • 203 tis. Kč
    • •
  • 203 tis. Kč
    • •
  • MŠMT
Project

Sensing of hepatitis B virus-infected hepatocytes by plasmacytoid dendritic cells (GA17-15422S)

The role of plasmacytoid dendritic cells (pDCs), a major source of interferon (IFN) alpha in human organism, in pathogenesis of hepatitis B virus (HBV) infection is not clear. We hypothesize that pDCs could be involved via production of IFN-alpha and...

EE - Mikrobiologie, virologie

  • 2017 - 2021
    • •
  • 7 608 tis. Kč
    • •
  • 6 891 tis. Kč
    • •
  • GA ČR
Project

Complexes of IL-2 and anti-IL-2 mAb with selective stimulatory activity for CD25+ T cells in cancer immunotherapy changing the paradigm (GA22-20548S)

Complexes of IL-2 and anti-IL-2 mAbs possess extremely high biological activity in vivo. Moreover, such IL-2 complexes have selective stimulatory activity for different IL-2 responsive cells depending on the clone ...

Oncology

  • 2022 - 2024
    • •
  • 8 330 tis. Kč
    • •
  • 8 330 tis. Kč
    • •
  • GA ČR
Project

Strong sustained IL-2 signal selectively targeted to CD25+ cells dramatically increases sensitivity to LPS-mediated mortality finding the mechanism (GA13-12885S)

It has been shown previously that complexing IL-2 with certain anti-IL-2 mAb enourmously increases activity of IL-2 in vivo. These immunocomplexes selectively stimulate different subsets of immune cells depending on clone ...

EC - Imunologie

  • 2013 - 2018
    • •
  • 11 872 tis. Kč
    • •
  • 11 872 tis. Kč
    • •
  • GA ČR
Project

IL-2 complexed with muteins of JES6-1 mAb having different affinity to IL-2 finding variant with most selective stimulation of Treg cells in vivo (GA18-12973S)

Complexes of IL-2 and anti-IL-2 mAb JES6-1 potently expand CD25+ cells, i.e to understanding the mechanism how these complexes interact with high affinity trimeric IL-2 receptor. JES6-1 mAb sterically blocks the interaction...

Immunology

  • 2018 - 2022
    • •
  • 4 804 tis. Kč
    • •
  • 4 762 tis. Kč
    • •
  • GA ČR
Project

*Modernization of the VS 2 ejection seat. (FT-TA3/046)

*Modernization of the VS 2 ejection seat....

JU - Aeronautika, aerodynamika, letadla

  • 2006 - 2008
    • •
  • 35 869 tis. Kč
    • •
  • 18 212 tis. Kč
    • •
  • MPO
Project

Study of anion processes relevant for astrophysics (7AMB14AT023)

The primary objective of the project on the czech side is the measurement of the temperature dependence of the rate coefficients of O - + H 2 -> H 2 O + e - O - + H 2 of the isotopicexchange H 2 /D 2 . The...

CF - Fyzikální chemie a teoretická chemie

  • 2014 - 2015
    • •
  • 200 tis. Kč
    • •
  • 200 tis. Kč
    • •
  • MŠMT
Project

Aspects of immune response and efficacy of booster dose of SARS-CoV-2 mRNA vaccine in kidney transplant recipients (NU22-C-126)

1) Evaluate safety and imunogenicity of booster dose of SARS-CoV-2 mRNA vaccine in kidney transplant recipients. 2) Evaluate association between booster dose of SARS-CoV-2 mRNA vaccine and risk of SARS-CoV-2 infect...

Transplantation

  • 2022 - 2023
    • •
  • 6 194 tis. Kč
    • •
  • 6 194 tis. Kč
    • •
  • MZ
Project

Synthesis of nonracemic helical aromatics employing transition metal catalysis (GA203/07/1664)

: (a) diastereoselective [2+2+2] cyclotrimerisation of aromatic triynes containing two asymmetric) diastereoselective [2+2+2] cyclotrimerisation of chiral complexes of pyridine triynes with chiral...

CC - Organická chemie

  • 2007 - 2009
    • •
  • 3 059 tis. Kč
    • •
  • 3 059 tis. Kč
    • •
  • GA ČR
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