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6 769 (0,106s) •

Project

Influence of Toll-like Receptor Agonists on Immunogenicity of Tumour Cells in B cell Chronic Lymphocytic Leukemia (GP310/08/P353)

receptors on B-CLL tumour cells. We will monitor activation status of B-CLL cells incurable with conventional therapy. B-CLL tumour cells are weakly immunogenic which may that enhance th...

EC - Imunologie

  • 2008 - 2010
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • GA ČR
Project

The role of sphingosine-1-phosphate receptor 1 in B cell mechanosensitivity. (GA25-16907S)

-phosphate receptor 1 (S1PR1) control the speed of mechanically triggered B cells confinement triggers rapid motility of primary B cells in the absence of chemical signal of S1PR1 in B cells

Cell biology

  • 2025 - 2027
    • •
  • 11 919 tis. Kč
    • •
  • 11 919 tis. Kč
    • •
  • GA ČR
Project

Molecular Aspects of B-cell Receptor Signal Initiation as Targets for Specific Therapy of non-Hodgkin Lymphoma. (NV18-03-00117)

chemotherapy combination over 40 years old. The B-cell receptor (BCR) inhibition is such emerging therapy applicable to various B-cell derived NHL, which were shown to use) and “tonic” (analogous to basel...

Oncology

  • 2018 - 2022
    • •
  • 11 156 tis. Kč
    • •
  • 11 156 tis. Kč
    • •
  • MZ
Project

Molecular mechanisms of signaling through leukocyte receptors their role in health and disease. (GBP302/12/G101)

). Functional analysis of human B-cell development and B-cell receptor assembly and editing and B-cell interplay with T-lymphocytes in relation to B cell malignant r...

EC - Imunologie

  • 2012 - 2018
    • •
  • 75 061 tis. Kč
    • •
  • 75 061 tis. Kč
    • •
  • GA ČR
Project

Crosstalk between nuclear receptor and Wnt signaling in C. elegans (GA204/07/0948)

Nuclear receptor and Wnt signaling pathways intersect during cell interplay between a conserved nuclear receptor NHR-25 and a Wnt pathway during cell fate decision in vivo. Our model is the C. elegans somatic gonad...

EB - Genetika a molekulární biologie

  • 2007 - 2011
    • •
  • 3 802 tis. Kč
    • •
  • 3 802 tis. Kč
    • •
  • GA ČR
Project

Clinical and prognostic significance of BAFF (B-cell activating factor) and its receptors in idiopatic inflammatory myopathies (NT12438)

a) Quantitative analysis of serum levels of BAFF (B cell activating factor of the TNF family) and expression of its receptors (BAFF-R, TACI and BCMA) on immunologically relevant cells in peripheral blood and muscle...

FE - Ostatní obory vnitřního lékařství

  • 2011 - 2014
    • •
  • 5 276 tis. Kč
    • •
  • 5 276 tis. Kč
    • •
  • MZ
Project

Analysis of clonal heterogeneity in chronic lymphocytic leukemia using next generation sequencing of B cell receptor. A national study. (NV15-30015A)

Chronic lymphocytic leukemia (CLL) is characterized by extraordinary heterogeneity concerning clinical presentation and molecular features. As the clonal disease of B lymphocytes, each case can be described by a specific immunoglobulin gene ...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 15 351 tis. Kč
    • •
  • 15 028 tis. Kč
    • •
  • MZ
Project

Changes in expression of adhesion molecules a tool for prediction of extramedullary relapse of B cell acute lymphoblastic leukemia following blinatumomab treatment (NU23J-03-00033)

the connection of the CD19 receptor on malignant B-cells to CD3 on effector T-lymphocytes, cytoskeleton changes induced by B-cell receptor (BCR), a vital component of the immune) is unusually com...

Immunology

  • 2023 - 2026
    • •
  • 6 937 tis. Kč
    • •
  • 6 937 tis. Kč
    • •
  • MZ
Project

Molecular Characterization of B-cell Receptors and Their Relationship to Evolution of Gemonic Aberrations in Chronic Lymphocytic Leukemia (NT13493)

Variable course of chronic lymphocytic leukemia (CLL) is influenced by many factors. The signalization via B-cell receptor (BCR) belongs among them; its intensity potential of malignant cells which influence hetero...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 8 737 tis. Kč
    • •
  • 8 737 tis. Kč
    • •
  • MZ
Project

THE REGULATION OF B CELL RECEPTOR (BCR) SIGNALLING PATHWAY BY MICRORNAS (GJ16-13334Y)

We hypothesize that microRNAs (miRNAs) contribute to the regulation of B-cell receptor (BCR) signalling and microenvironmental interactions in normal and malignant B cells. We plan to uncover how specific ...

FD - Onkologie a hematologie

  • 2016 - 2018
    • •
  • 3 293 tis. Kč
    • •
  • 3 293 tis. Kč
    • •
  • GA ČR
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