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2 044 (0,195s) •

Project

Lung surfactant under oxidative stress molecular dynamics simulations and Langmuir film experiments (GA17-06792S)

The lung surfactant is a mixture of lipids with small fraction of proteins that covers the air-water interface of alveoli. It experiences significant oxidative stress due to a variety of oxidizing agents to which it is expo...

CF - Fyzikální chemie a teoretická chemie

  • 2017 - 2021
    • •
  • 6 164 tis. Kč
    • •
  • 5 975 tis. Kč
    • •
  • GA ČR
Project

Corneocyte lipid envelope lipid-protein binding mechanisms and barrier rescue in ichthyosis models (GA24-10736S)

Disturbed formation of corneocyte lipid envelope (CLE) was described in severe have not been fully explained yet. In this project, oxidized human acylceramides the attachment of these lipids to model aminoacids (including a...

Biophysics

  • 2024 - 2026
    • •
  • 8 301 tis. Kč
    • •
  • 8 301 tis. Kč
    • •
  • GA ČR
Project

Lipid Metabolism and Oxidative Stress Parameters in Perinatal Period with Respect of Their Therapeutic Influence and Monitoring (NE6738)

The aim of this project is the investigation of oxidative stress during perinatal period in both healthy and diabetic mothers and their infants depending on the degree of their maturity, nurishmant status, and adaptation after delivery. Furt...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 2 296 tis. Kč
    • •
  • 2 276 tis. Kč
    • •
  • MZ
Project

Oxidative damage to retina and eys during hypoxia and hyperoxia (IZ4009)

Oxidative damage to retina and eye lens induced by hypoxia and hyperoxia in laboratory rat will be investigated at the level of lipids,structual proteins,and metabolic activity.The goal is to elucidate the mechanismus of cataract an...

FF - ORL, oftalmologie, stomatologie

  • 1997 - 1999
    • •
  • 816 tis. Kč
    • •
  • 816 tis. Kč
    • •
  • MZ
Project

Influence of cadmium and mercury compounds and fish lipids on cell lipid metabolism, oxidative stress and cell viability (GA13-01543S)

of cancer It remains to evaluate if Cd2+ and Hg2+ also influence lipid composition respectively. The work will focus on oxidative stress, phospholipid- and fatty acid......

GM - Potravinářství

  • 2013 - 2017
    • •
  • 5 190 tis. Kč
    • •
  • 5 190 tis. Kč
    • •
  • GA ČR
Project

The influence of lipid emulsions on glucose oxidation during parenteral nutrition. (IZ2964)

9F - 9

  • 1995 - 1996
    • •
  • 224 tis. Kč
    • •
  • 225 tis. Kč
    • •
  • MZ
Project

Effect of simultaneous administration of energy substrates on glucose, fat and protein metabolism in patients with insulin resistance. (NB4903)

The aim of the study is to evaluate the effect of lipid emulsion containing long chain fatty acid (LCT) and middle plus long chain fatty acids (MCT/LCT) on glucose utilisation, oxidation of glucose, lipids and proteins, hep...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 4 572 tis. Kč
    • •
  • 4 291 tis. Kč
    • •
  • MZ
Project

Effect of silymarin combined with hypolipidemics on mechanisms leading to lipids accumulation, oxidative stress and inflammation in metabolic syndrome (GA17-08888S)

of action of combined effects of these drugs on ectopic lipid accumulation, oxidativeThe main aim of the project is to find out new possibilities of effective therapy of dyslipidemia, oxidative stress and inflammation as i...

FR - Farmakologie a lékárnická chemie

  • 2017 - 2021
    • •
  • 6 194 tis. Kč
    • •
  • 6 076 tis. Kč
    • •
  • GA ČR
Project

Investigation of lipid Langmuir monolayers interacting with atmospheric oxidants and pollutants by molecular simulations (GA13-06181S)

chemistry will be used to study structural and dynamical properties of lipid films combinations as well as their changes due to oxidation and interaction with impurities......

CF - Fyzikální chemie a teoretická chemie

  • 2013 - 2015
    • •
  • 8 393 tis. Kč
    • •
  • 8 393 tis. Kč
    • •
  • GA ČR
Project

Eukaryotic cell membrane as a target site for environmental stress factors (ME 315)

mechanism of interaction is lipid peroxidation, metal-catalyzed oxidation or nonradical reaction, and determine types OF enzyme damage (amino acid side chain oxidation, fragmentation, cross-linking). The oxidant a...

EE - Mikrobiologie, virologie

  • 1999 - 2001
    • •
  • 1 136 tis. Kč
    • •
  • 500 tis. Kč
    • •
  • MŠMT
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