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166 (0,122s) •

Project

Population pharmacodynamic/pharmacokinetic modelling in clinical pharmacology. (OC B15.10)

Population pharmacodynamic/pharmacokinetic modelling in clinical pharmacology of antiepileptic and antipsoriatic drugs....

FR - Farmakologie a lékárnická chemie

  • 1999 - 2003
    • •
  • 5 480 tis. Kč
    • •
  • 3 095 tis. Kč
    • •
  • MŠMT
Project

Changes in pharmacokinetics and pharmacodynamics of drugs in the presence of impaired liver function (1P05OC062)

introduction of suitable in vivo and in vitro methods for prediction and evaluation of pharmacokinetics and pharmacodynamic properties of substances at hepatic damage......

FR - Farmakologie a lékárnická chemie

  • 2005 - 2008
    • •
  • 2 526 tis. Kč
    • •
  • 2 526 tis. Kč
    • •
  • MŠMT
Project

Physiologically based prediction of pharmacokinetics prior to in vivo studies Focus on hepatic and renal drug elimination (1P05OC061)

possibilities of combined usage of in vitro methods and computational models in silico for prediction of pharmacokinetics in vivo...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2008
    • •
  • 2 526 tis. Kč
    • •
  • 2 526 tis. Kč
    • •
  • MŠMT
Project

Changes of pharmacokinetics of vancomycin and gentamicin in continual and intermittent elimination methods in sepsis and acute kidney insufficiency, the use of a predictive pharmacokinetic model (NS10309)

on pharmacokinetics of selected antibiotics will be assessed. Using a predictive model the target...

FR - Farmakologie a lékárnická chemie

  • 2009 - 2011
    • •
  • 3 159 tis. Kč
    • •
  • 3 070 tis. Kč
    • •
  • MZ
Project

Population modelling of wanted and unwanted clinical outcomes and surrogate parameters (1P04OCB15.10)

Population pharmacodynamic/pharmacokinetic modelling in clinical pharmacology of antiepileptic and antipsoriatic drugs....

FP - Ostatní lékařské obory

  • 2004 - 2004
    • •
  • 687 tis. Kč
    • •
  • 687 tis. Kč
    • •
  • MŠMT
Project

Developmental Pharmacokinetics and Pharmacogenetic Aspects of Analgesic Sedation by Tramadol in Newborns, Infants and Older Children Treated at the Intensive Care Unit (1A8632)

The aim of the study is to describe if maturation of biotransformation pathways changes pharmacokinetic parameters of tramadol and wheather the genetic polymorphism of CYP2D6 influences this develpmental variability. We will also evaluate th...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2009
    • •
  • 3 412 tis. Kč
    • •
  • 3 288 tis. Kč
    • •
  • MZ
Project

Stochastic model of residence time in pharmacokinetics and its analysis (IZ4034)

To propose statistical methods suitable for estimation of parameters in circulatory transport in pharmacokinetics. To derive a method for identification of absorption rate in case of unavailable concentration-time curve.......

FR - Farmakologie a lékárnická chemie

  • 1997 - 1999
    • •
  • 523 tis. Kč
    • •
  • 447 tis. Kč
    • •
  • MZ
Project

Pharmaceutical analysis, pharmacokinetic and biotransformation study of novel thiosemicarbazone anticancer drugs (NT12403)

and to evaluate their pharmacokinetics. Particular attention will be paid on elimination pharmacokinetic profile and potentially also toxicological profile.......

FR - Farmakologie a lékárnická chemie

  • 2011 - 2013
    • •
  • 2 025 tis. Kč
    • •
  • 2 025 tis. Kč
    • •
  • MZ
Project

Determination of important pharmacokinetic and biochemical parameters and evaluation of blood-brain barrier penetration using drugs introduced to Czech Army (OVUOFVZ200811)

The aim of this project is to charakterize pharmacokinetics of substances using in therapy by intoxications. Mainly their distribution in body tissues, in vitro and in vivo testing of ability to penetrate into central nervous system and thei...

FP - Ostatní lékařské obory

  • 2008 - 2011
    • •
  • 1 927 tis. Kč
    • •
  • 932 tis. Kč
    • •
  • MO
Project

Interactions of galanthamine with modulators of membrane transport in the central nervous system (NR7935)

Determination of acetylcholinesterase activity, pharmacokinetics and adverse events of galanthamine with L-carnitine, cyclosporine A, nitrendipine and nitroarginine metylester. The aim is contribute to improve therapy of cognitive disordes.....

FR - Farmakologie a lékárnická chemie

  • 2004 - 2006
    • •
  • 2 598 tis. Kč
    • •
  • 2 312 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 166