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3 071 (0,097s) •

Project

Inherited disorders of hematopoessis (NE6689)

Molecular genetic studies of the pathogenesis of Diamond-Blackfan anemia (DBA). Genetic analysis of candidate genes for DBA/ the role of haploinsuficiency of ribosomal protein S19 (RPS) in human hematopoiesis Murine model o...

FG - Pediatrie

  • 2001 - 2003
    • •
  • 4 817 tis. Kč
    • •
  • 4 688 tis. Kč
    • •
  • MZ
Project

Diamond-Blackfan anaemia molecular-genetic analysis of ethiopathogenetic factors, analysis of their influence on prognosis and treatment. (NT11059)

. The etiology was only partly elucidated in 1999 with the discovery of mutated ribosomal protein (RP) S19. DBA is the first known hematological disease caused by ribosomal protein mutations. Recent studie...

FG - Pediatrie

  • 2010 - 2013
    • •
  • 6 244 tis. Kč
    • •
  • 6 244 tis. Kč
    • •
  • MZ
Project

Structure and dynamics of the ribosome exit tunnel (GJ19-06479Y)

, the newly synthesized protein - the nascent chain - leaves the ribosome through a tunnel. The tunnel walls are made of ribosomal RNA and three ribosomal proteins. The exact role of the proteins ...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 3 611 tis. Kč
    • •
  • 3 611 tis. Kč
    • •
  • GA ČR
Project

Yeast model organism of aging and apoptosis (MEB060816)

Description of ribosomal proteins ? ribosomal profil, during the aging process of yeast model system...

EB - Genetika a molekulární biologie

  • 2008 - 2009
    • •
  • 93 tis. Kč
    • •
  • 93 tis. Kč
    • •
  • MŠMT
Project

Ribosomal stress mechanisms and relevance to cancer (GA17-14743S)

Protein translation is performed by ribosomes, complex macromolecular machines comprised of ribosomal proteins and ribosomal RNAs. Synthesis of ribosomes consumes. Here we want to identify rib...

FD - Onkologie a hematologie

  • 2017 - 2019
    • •
  • 10 734 tis. Kč
    • •
  • 9 987 tis. Kč
    • •
  • GA ČR
Project

Analysis of genetic background of Diamond-Blackfan anemia (GP301/04/P199)

Diamond-Blackfan anemia (DBA) is characterized by normochromic macrocytic anemia and a selective deficiency of bone marrow red cell precursors. Recently ribosomal protein S19 (RPS19) has been found to be mutated in 25% of D...

FD - Onkologie a hematologie

  • 2004 - 2005
    • •
  • 599 tis. Kč
    • •
  • 599 tis. Kč
    • •
  • GA ČR
Project

Towards atomistic understanding of the first moments in the life of protein (GA23-05557S)

. It happens on ribosomes, where amino acids are interconnected by chemical bonds one at a time, to create a non-branched chain, the protein. One important part of the ribosome is a tunnel, through which the nascent pro...

Biophysics

  • 2023 - 2025
    • •
  • 3 883 tis. Kč
    • •
  • 3 883 tis. Kč
    • •
  • GA ČR
Project

Phosphorylation of the translational apparatus during development and differentiation in streptomycetes (GA204/98/0421)

this response. High-salt washes of ribosomes will be analyzed for protein kinase activity and the possible role or ribosomes in the protein kinase activity examined. The protein kinase form of EF-Tu and <...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 2 013 tis. Kč
    • •
  • 1 619 tis. Kč
    • •
  • GA ČR
Project

Cold-shock proteins of streptomycetes and their role in regulation of gene expression (GA203/98/0422)

phosphorylation/dephosphorylation of ribosomal proteins is involved in modulation association of proteins, mRNA and tRNA to ribosome. Helix-destabilizing activity of the induced proteins by downshift in t...

CE - Biochemie

  • 1998 - 2000
    • •
  • 1 525 tis. Kč
    • •
  • 1 525 tis. Kč
    • •
  • GA ČR
Project

The role of peptides in the emergence of primordial ribosomes (GA25-15428S)

Ribosome is an efficient catalyst of protein synthesis present in all forms of known life. Its biochemical origins trace back to the era when early biomolecules that gave rise to specific protein-RNA interactions forming th...

Biophysics

  • 2025 - 2027
    • •
  • 8 560 tis. Kč
    • •
  • 8 389 tis. Kč
    • •
  • GA ČR
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