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19 (0,122s) •

Project

Molecular Basis of Bilirubin Neurotoxicity (LH 15097)

1. Establishment of the method for quantitative determination of bilirubin photoisomers; 2. In vitro studies of potential neurotoxic effects of bilirubin photoisomers; 3. In vitro studies of potential neurotoxic effects of bilir...

CE - Biochemie

  • 2016 - 2017
    • •
  • 1 962 tis. Kč
    • •
  • 1 962 tis. Kč
    • •
  • MŠMT
Project

Antiproliferative effects of bilirubin, heme metabolites, and heme oxygenase expression on colon and pancreatic cancer. (ME 849)

detailed study on the role of bilirubin metabolism in phatogenesis of colon and pancreatic cancer, basic research, database research...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 2 890 tis. Kč
    • •
  • 2 770 tis. Kč
    • •
  • MŠMT
Project

Isolation and characterization of bilirubin reductase gene from bacteria of Clostridium genus and its potential therapeutic use (GA310/02/1436)

Bilirubin is a key degradation product of heme. Excessive production, defective hepatic elimination as well as decreased intestinal catabolism of bilirubin result in elevation of serum bilirubin levels. Severe hyperbilirubi...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2002 - 2004
    • •
  • 4 926 tis. Kč
    • •
  • 3 678 tis. Kč
    • •
  • GA ČR
Project

Induction of hyperbilirubinemia by plant flavonolignans as a new tool for the prevention of increased oxidative stress (NV16-27317A)

Bilirubin is the major product of the heme catabolic pathway and its serum. The beneficial effects of mildly elevated serum bilirubin levels are detectable with even catabolic pathway, heme oxygenase (HMOX) and bilirubin UD...

CE - Biochemie

  • 2016 - 2019
    • •
  • 9 111 tis. Kč
    • •
  • 9 111 tis. Kč
    • •
  • MZ
Project

Studies of the bilirubin degradation products formed during phototherapy of neonatal jaundice (NV18-07-00342)

use of phototherapy in clinical neonatology, only little is known about bilirubin performed to systematically explore the whole process of bilirubin photooxidation. All......

Paediatrics

  • 2018 - 2021
    • •
  • 11 485 tis. Kč
    • •
  • 11 485 tis. Kč
    • •
  • MZ
Project

Unconjugated hyperbilirubinemias - study of new therapeutical approaches and of the role of bilirubin on organism. (NB4866)

Study of new therapeutical procedures in unconjugated hyperilirubinemias with focusing on identification of factors responsible for bilirubin conversion in intestinal lumen. Study of the influnce of hyperbilirubinemia on organism in the cond...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 2 474 tis. Kč
    • •
  • 2 224 tis. Kč
    • •
  • MZ
Project

Bilirubin as a risk factor of cardiovascular disease development. (NV15-28895A)

the UGT1A1 and HMOX genes and theirs association with biochemical parameters (bilirubin/ bilirubin levels, ii/ risk of developing CVD and finally iii/ one-year cardiovascular......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2018
    • •
  • 4 605 tis. Kč
    • •
  • 4 605 tis. Kč
    • •
  • MZ
Project

The role of heme catabolic pathway in in the pathogenesis of cholestasis (NR9366)

The proposed grant project is focused on the role of HO and its metabolic products, bilirubin and carbon monoxide (CO) on the maintenance of bile flow and sinusoidal tone in the liver tissue, in particular its role in the pathogenesis of cho...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2010
    • •
  • 4 406 tis. Kč
    • •
  • 4 406 tis. Kč
    • •
  • MZ
Project

Synthesis and Photochemistry of Isotope Labeled Probes of Neonatal Jaundice Phototherapy. (GA22-27598S)

chemistry to enable the preparation of fully synthetic bilirubin and many of its known regarding the formation and reactivity of the bilirubin degradation products under......

Organic chemistry

  • 2022 - 2024
    • •
  • 7 195 tis. Kč
    • •
  • 7 195 tis. Kč
    • •
  • GA ČR
Project

Study of new therapeutical procedures in unconjugated hyperbilirubinemia. (IZ2226)

9F - 9

  • 1994 - 1996
    • •
  • 725 tis. Kč
    • •
  • 965 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 19