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1 608 (0,076s) •

Project

BIOINFORMATICS AND FUNCTIONAL ANALYSES OF SUSCEPTIBILITY VARIANTS SUPPORTING THE NGS-BASED TESTING OF HEREDITARY CANCERS IN THE CZECH REPUBLIC (II) (NU20-03-00285)

laboratories unifying cancer predisposition analysis by CZECANCA (Czech cancer panel in these activities to comprehensively characterize genetic architecture of cancer predispositionTargeted next gene seq...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2020 - 2023
    • •
  • 11 831 tis. Kč
    • •
  • 11 831 tis. Kč
    • •
  • MZ
Project

Germline mutations of PML gene in patients with cancer (NR9092)

Mutational analysis of PML gene will be performed in patients with breast and colon cancer with suspect hereditary predisposition to cancer. Cyclin D1 and ZNF217 gene amplification analysis will be performed in breast c...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 2 645 tis. Kč
    • •
  • 2 244 tis. Kč
    • •
  • MZ
Project

Hereditary cancer predisposition in breast or colorectal cancer patients not indicated for routine genetic testing (NU20-03-00283)

in tens of clinically relevant cancer predisposition genes influences treatment strategies in cancer patients and determinate cancer prevention in asymptomatic carriersPatients with hereditary cancer synd...

Oncology

  • 2020 - 2023
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  • 11 720 tis. Kč
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  • 11 720 tis. Kč
    • •
  • MZ
Project

Characterization of genetic predisposition to ovarian cancer using genomic approaches in patients diagnosed with ovarian cancer before the age of 30 (NU20-03-00016)

with known/anticipated predisposition to ovarian cancer in patients diagnosed with ovarian cancer before the age of 30. Whereas mutation frequency in 18 predispositionOvarian cancer is a disease with a hi...

Genetics and heredity (medical genetics to be 3)

  • 2020 - 2023
    • •
  • 10 063 tis. Kč
    • •
  • 10 063 tis. Kč
    • •
  • MZ
Project

Unique molecular biology of paediatric brain tumours associated with cancer predisposition syndromes (NU21-07-00419)

studies suggest that around 10% of patients harbour cancer predisposition syndrome the incidence of cancer predisposition syndromes in children with brain tumours is unknown of cancer predisposition

Human genetics

  • 2021 - 2024
    • •
  • 13 486 tis. Kč
    • •
  • 13 486 tis. Kč
    • •
  • MZ
Project

Identification of inherited DNA polymorphisms in genes of testosterone synthetic pathway as factors of genetic predisposition to development of prostate cancer and their use in prevention (NR8039)

Proposed project is focused on clinical study of inherited genetic polymorphisms and their association with prostate cancer for their potential application in preventive screening. Current as well as new prostate cancer patients wil...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 4 906 tis. Kč
    • •
  • 4 618 tis. Kč
    • •
  • MZ
Project

Study of genetic predispositions to colorectal cancer (NR8294)

We will study germline mutations in the MLH1, MSH2, MSH6, and MYH genes as a possible molecular cause of the disease in patients with colorectal cancer (CRC) and positive family history of CRC by using methods of molecular genetics. Results ...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 3 100 tis. Kč
    • •
  • 3 047 tis. Kč
    • •
  • MZ
Project

Psychosocial aspects of hereditary forms of breast and ovarian cancer. The study of women with proved hereditary etiology. (NR8022)

Psychosocial effect of genetic counseling and testing of hereditary etiology of breast/ovarian cancer. The influence of testing on quality of life of high-risk women. Mapping of the level of preventive care of women with hereditary predi...

FQ - Veřejné zdravotnictví, sociální lékařství

  • 2004 - 2006
    • •
  • 2 244 tis. Kč
    • •
  • 2 214 tis. Kč
    • •
  • MZ
Project

Classification of variants of unknown significance in cancer susceptibility genes by the multiplex PCR/NGS-based analysis of their impact on pre-mRNA splicing (NV18-03-00024)

Clinical management that enables efficient cancer prevention in carriers of germ-line alterations in cancer susceptibility genes requires and unequivocal characterization of the pathogenic mutation. Current cancer predi...

Genetics and heredity (medical genetics to be 3)

  • 2018 - 2021
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  • 9 940 tis. Kč
    • •
  • 9 775 tis. Kč
    • •
  • MZ
Project

Targeted NEXT-GEN sequencing as a tool for identification of the new breast cancer susceptibility genes in high-risk patients (NT14054)

Candidate genetic BC predisposition factors will be identified using the next-gen sequencing on SOLiD4 analyzer. Entire coding sequence of >250 selected genes isolated by exon trapping will be analyzed in 300 samples of high-risk (BRCA1/2-ne...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 7 202 tis. Kč
    • •
  • 7 202 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 1 608