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1 607 (0,066s) •

Project

Study of synergisms of anticancer drug ellipticine and alfa5 beta1 integrin in brain cancer treatment (MEB020837)

The target of the project is investigation of synergisms of anticancer drug ellipticine and alfa5 beta1 integrin, which can be utilized in treatment of cancer such as brain tumors.......

CE - Biochemie

  • 2008 - 2009
    • •
  • 29 tis. Kč
    • •
  • 29 tis. Kč
    • •
  • MŠMT
Project

*New anticancer drugs - Use of modern biotechnology for the research and development of new anticancer drugs. (FT-TA/027)

*The outcome of the project is to develop 1 - 3 active substances with confirmed anticancer activity and know and low toxicity. These compounds will be used for further development in IQA after project will be finished. The project will faci...

FR - Farmakologie a lékárnická chemie

  • 2004 - 2007
    • •
  • 16 245 tis. Kč
    • •
  • 8 355 tis. Kč
    • •
  • MPO
Project

Structure and properties of paramagnetic ruthenium complexes for designing new anticancer drugs (GA15-09381S)

We propose to study novel candidates for ruthenium anticancer drugs based on ruthenium complexes protected by cucurbit[n]uril and bambus[n]uril cavitands of their importance, to the new potential candidates for anticancer <...

CF - Fyzikální chemie a teoretická chemie

  • 2015 - 2017
    • •
  • 5 685 tis. Kč
    • •
  • 5 685 tis. Kč
    • •
  • GA ČR
Project

Study on the role of novel targeted breast and lung anticancer drugs in the phenomenon of pharmacokinetic drug resistance (GJ20-20414Y)

major cause of anticancer pharmacotherapy failure in oncological patients. This phenomenon is often caused by pharmacokinetic mechanisms, i.e. drug efflux by ABC drug transporters and/or inactivation by drug metab...

Pharmacology and pharmacy

  • 2020 - 2022
    • •
  • 4 909 tis. Kč
    • •
  • 4 869 tis. Kč
    • •
  • GA ČR
Project

Mechanism of action of polymeric drugs and their intracellular distribution (GP305/04/P004)

)-methacrylamide (HPMA) [1-7] are used as a carriers for anticancer drug - doxorubicin]. To improve the properties of currently used anticancer polymeric conjugates the detailed characterization of pharmacokinetics, dru...

EC - Imunologie

  • 2004 - 2006
    • •
  • 851 tis. Kč
    • •
  • 851 tis. Kč
    • •
  • GA ČR
Project

The study of the thermodynamic stability of DNA modified by new anticancer platinum complexes (LZ1K03010)

class of clinical anticancer drugs.The project is focused on studies of the mechanism underlying anticancer in the specific recognition of modified DNA by proteins that participate inthe anticancer on DNA will be ...

BO - Biofyzika

  • 2003 - 2004
    • •
  • 1 066 tis. Kč
    • •
  • 799 tis. Kč
    • •
  • MŠMT
Project

DNA Reaction with Platinum Group Metals. Relation to the Development of New Anticancer Drugs (GA203/93/0052)

9J - 9

  • 1993 - 1995
    • •
  • 273 tis. Kč
    • •
  • 546 tis. Kč
    • •
  • GA ČR
Project

The next generation of platinum anticancer drugs. Molecular and cellular mechanisms of action (LTAUSA18009)

The aim of this project is to improve current knowledge on structure-pharmacological relationships of metallodrugs derived from new platinum complexes and in this way to broaden in a substantial way the theoretical background needed for design and de...

Pharmacology and pharmacy

  • 2019 - 2022
    • •
  • 6 432 tis. Kč
    • •
  • 6 432 tis. Kč
    • •
  • MŠMT
Project

Involvement of nuclear HMGB proteins in sensitizing of human cells to anticancer drugs inhibiting DNA topoisomerases (GAP301/10/0590)

Separation of the two DNA strands results in superhelical tension resolved by topoisomerases, which are cellular targets of numerous anticancer drugs. The proposed project is based on our preliminary or published data indicating a p...

FD - Onkologie a hematologie

  • 2010 - 2012
    • •
  • 4 859 tis. Kč
    • •
  • 4 859 tis. Kč
    • •
  • GA ČR
Project

Role of Cytochromes P450 in the Effects of Cytostatics in Patients and Medical Personnel. (IZ1850)

Cytochromes P450 activate many carcinogens and anticancer to effective metabolites. Genetic and environmental factors influence P 450 activuty. The proposal studies relation of P450 activity to the effects of anticancer drugs

FM - Hygiena

  • 1995 - 1999
    • •
  • 4 852 tis. Kč
    • •
  • 3 817 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 1 607