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117 (0,127s) •

Project

Ribosomal stress mechanisms and relevance to cancer (GA17-14743S)

Protein translation is performed by ribosomes, complex macromolecular machines comprised of ribosomal proteins and ribosomal RNAs. Synthesis of ribosomes consumes and proliferation. Ribosome biogenesis is ...

FD - Onkologie a hematologie

  • 2017 - 2019
    • •
  • 10 734 tis. Kč
    • •
  • 9 987 tis. Kč
    • •
  • GA ČR
Project

Yeast model organism of aging and apoptosis (MEB060816)

Description of ribosomal proteins ? ribosomal profil, during the aging process of yeast model system...

EB - Genetika a molekulární biologie

  • 2008 - 2009
    • •
  • 93 tis. Kč
    • •
  • 93 tis. Kč
    • •
  • MŠMT
Project

Ribosome biogenesis in apoptosis and aging (MEB061009)

The study of apoptosis and ribosome associated cellular aging will be used in this research proposal to investigate the effect of ribosome biogenesis on these processes the effect of gene dosage variation of selected regulators of <...

EB - Genetika a molekulární biologie

  • 2010 - 2011
    • •
  • 90 tis. Kč
    • •
  • 90 tis. Kč
    • •
  • MŠMT
Project

Structural basis for bacterial ribosome rescue and recycling (8J18DE010)

1. Cryo-EM structure of ArfA bound to a non-stop ribosome The goal of this project is to ascertain how ArfA initially binds to the non-stop ribosomes before recruiting RF2. In particular, how ArfA distinguishes non-stop ribosome...

Cell biology

  • 2018 - 2019
    • •
  • 66 tis. Kč
    • •
  • 66 tis. Kč
    • •
  • MŠMT
Project

Structure and dynamics of the ribosome exit tunnel (GJ19-06479Y)

The ribosome is a huge biomolecular complex, which catalyzes peptide bond is produced. The catalytic site is buried deep in the large ribosomal subunit. Hence, the newly synthesized protein - the nascent chain - leaves the ribos...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 3 611 tis. Kč
    • •
  • 3 611 tis. Kč
    • •
  • GA ČR
Project

Study of the regulation of ribosomal RNA synthesis in normal and malignant blood cells. (NC5933)

Investigation of the fuctional link between expression and phosphorylation of nucleolar transcription factors and regulatory mechanism of ribosomal RNA synthesis performed on normal and leukemic blood cells with stimulated or respressed grow...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 5 011 tis. Kč
    • •
  • 4 685 tis. Kč
    • •
  • MZ
Project

Ribosomal stress, ribosomal DNA stability and cellular senescence role of PML (GA19-21325S)

Ribosome biogenesis is highly coordinated and energy demanding process of ribosomes and protein translation disorders cellular homeostasis and may cause of this project is to unravel mechanisms of the rDNA stability during ribo...

Human genetics

  • 2019 - 2023
    • •
  • 10 468 tis. Kč
    • •
  • 9 864 tis. Kč
    • •
  • GA ČR
Project

Function, structure and dynamics of the nuclear ribosome-producing machinery (GA304/04/0692)

Most of the ribosome biogenesis takes place in nucleoli and an exciting progress of the molecular knowledge about the ribosome biogenesis was achieved during and the spatial organization of the ribosomal gene tandem repeate...

EA - Morfologické obory a cytologie

  • 2004 - 2006
    • •
  • 5 980 tis. Kč
    • •
  • 4 928 tis. Kč
    • •
  • GA ČR
Project

Computational study of RNA multiple junctions localized in functionally important sites of the ribosome (KJB400040901)

The project is focused on study of ribosomal RNA multiple junctions complex molecules composed of RNA motifs/submotifs. These systems consist of non-standard pairs will be suggested. Characterization of ribosomal RNA motifs/submotif...

CE - Biochemie

  • 2009 - 2011
    • •
  • 717 tis. Kč
    • •
  • 717 tis. Kč
    • •
  • AV ČR
Project

Development of Novel Ribosome-Targeting Antibiotics (8F19006)

The overall objective is to identify, characterize and optimize molecules as novel lead compounds for the development of novel antimicrobial agents targeting translation.......

Microbiology

  • 2019 - 2022
    • •
  • 5 836 tis. Kč
    • •
  • 5 836 tis. Kč
    • •
  • MŠMT
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