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1 594 (0,071s)

Project

Integrative studies of molecular mechanisms of mammalian epitranscriptome (LTC18052)

The project is focused on methodical improvement of adenosine modifications in protein coding RNAs (mRNAs) and it mainly aims to integrate studies and look for functional interplay between the two most abundant adenosine modifications

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2018 - 2021
  • 3 574 tis. Kč
  • 3 574 tis. Kč
  • MŠMT
Project

Posttranscriptional modifications of tRNAs in Trypanosoma brucei (LH12104)

modifications. A large number of enzymes required for different modifications have now been modification enzymes in Trypanosoma brucei, an evolutionarily divergent and medically very important protist. Some tRNA modifi...

EB - Genetika a molekulární biologie

  • 2012 - 2015
  • 3 988 tis. Kč
  • 3 648 tis. Kč
  • MŠMT
Project

Posttranscriptional Regulation of Gene Expression in Pollen Tubes of Nicotiana Tabacum L. (GA204/94/0654)

9H - 9

  • 1994 - 1996
  • 1 343 tis. Kč
  • 1 994 tis. Kč
  • GA ČR
Project

Characterization of the 3' RNA uridylation in human cells (GA16-21341S)

Eukaryotic RNAs undergo a wide variety of posttranscriptional modifications, such as base modifications or 3'-end tailing. Only recently, 3'-terminal RNA uridylation has been identified as a key regulator of miRNA maturatio...

EB - Genetika a molekulární biologie

  • 2016 - 2020
  • 9 565 tis. Kč
  • 9 343 tis. Kč
  • GA ČR
Project

Characterization of the RNA substrate repertoire of the human demethylase FTO (GA14-25884S)

Eukaryotic RNAs undergo a wide variety of posttranscriptional base modifications. Some of them are known to be essential for RNA folding, intermolecular interactions or activity. The most prevalent eukaryotic mRNA modification

EB - Genetika a molekulární biologie

  • 2014 - 2018
  • 7 998 tis. Kč
  • 7 998 tis. Kč
  • GA ČR
Project

Identification and role of RNA surveillance and degradation factors in the regulation of gene expression (GA23-07372S)

Posttranscriptional untemplated 3’ prime terminal tailing of RNAs regulates several essential processes in eukaryotes. They can affect mRNA metabolism and protein synthesis by direct mRNA modifications or via tailing of regulatory n...

Biochemistry and molecular biology

  • 2023 - 2025
  • 11 816 tis. Kč
  • 11 816 tis. Kč
  • GA ČR
Project

The molecular mechanisms of noncanonical 3' terminal RNA tailing and its role in the metabolism of coding and noncoding RNAs (GA20-19617S)

Eukaryotic RNAs undergo a wide variety of posttranscriptional modifications, such as base modifications or nontemplated 3'-end tailing. The 3' terminal RNA uridylation plays diverse roles in RNA metabolism acting in both, p...

Biochemistry and molecular biology

  • 2020 - 2022
  • 10 824 tis. Kč
  • 10 806 tis. Kč
  • GA ČR
Project

Regulation of posttranscriptional gene silencing in transgene plants (GP521/01/P042)

The aim of the proposed project is to study posttrancriptional gene silencing in transgenic plants. Tobacco lines containing a neomycin phosphotransferase II reporter gene (nptll) and showing variable degree of its silencing will be used in experimen...

EB - Genetika a molekulární biologie

  • 2001 - 2003
  • 1 319 tis. Kč
  • 700 tis. Kč
  • GA ČR
Project

ADAR2-mediated RNA editing in the suprachiasmatic nucleus; focus on AMPA receptors (GA19-17037S)

RNA editing refers to posttranscriptional modifications of RNA, which fundamentally influences its maturation. Editing of adenosine to inosine is essential for the formation of functional properties of ionotropic glutamate channels ...

Neurosciences (including psychophysiology)

  • 2019 - 2023
  • 6 041 tis. Kč
  • 6 041 tis. Kč
  • GA ČR
Project

Embryonic gene expression and posttranscriptional gene silencing during bovine preimplantation development (GA523/09/1035)

activation using subtractive hybridization method. We will make posttranscriptional...

EB - Genetika a molekulární biologie

  • 2009 - 2011
  • 3 342 tis. Kč
  • 3 342 tis. Kč
  • GA ČR
  • 1 - 10 out of 1 594