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3 632 (0,107s) •

Project

Targeted Depletion of the TRP-VR1 in Murine Nociception Models for Treatment of Analgesics Resistant Pain (LTAB19024)

in vivo. This effect is achieved through targeted lentiviral shRNA interference of the gene therapy-based method for targeted depletion of the VR1 nociceptors neuropathic and cancer pain, using innovative lentiviral

Neurosciences (including psychophysiology)

  • 2019 - 2021
    • •
  • 1 200 tis. Kč
    • •
  • 1 200 tis. Kč
    • •
  • MŠMT
Project

The program of lentiviral infection health check in small ruminants using new methods of early laboratory diagnostics and markers of genetically determined resistance to infection as a selection (QJ1610096)

Objectives of the project are fully in conformity with the objectives of Subprogram I. Thus based on genetic screening suggest program of marker-assisted selection for resistance against lentiviral infections in small ruminants (sheep and pr...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2016 - 2018
    • •
  • 7 323 tis. Kč
    • •
  • 6 585 tis. Kč
    • •
  • MZe
Project

Membrane signalosomes of mast cells and basophils - targets for innovative therapies (LD12073)

The aim of this project is: 1. To contribute to determining the composition of the FceRI membrane signalosomes important for antigen-induced degranulation in mast cells. 2. To contribute to determining the composition of membrane signalosomes importa...

EC - Imunologie

  • 2012 - 2014
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • MŠMT
Project

Revealing the pathohysiological function of serine protease kallikrein 14 in vivo using mouse models (GP301/09/P662)

conditional knockout mice with targeted deletion of the Klk14 gene. To analyze overexpression ofKlk14 in the skin should be generated using a lentiviral vector, which targeting the epidermal barrier function and the skin i...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 589 tis. Kč
    • •
  • 2 589 tis. Kč
    • •
  • GA ČR
Project

Investigating the pathologic role of metalloproteinases in liver using transgenic mice with conditional expression of transgenes (IAA500520812)

mice by using lentiviral vectors with liver-specific and controllable expression...

EB - Genetika a molekulární biologie

  • 2008 - 2012
    • •
  • 5 911 tis. Kč
    • •
  • 4 841 tis. Kč
    • •
  • AV ČR
Project

Role of mitochondrial reactive oxygen species in regulation of pancreatic beta cell function (GPP304/10/P204)

-cells. Lentiviral expression system with cassette for miRNA targeting UCP2 of mitochondrial targeted antioxidant SkQ will be tested on b-cells and INS1E culture. All......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2010 - 2013
    • •
  • 1 491 tis. Kč
    • •
  • 1 491 tis. Kč
    • •
  • GA ČR
Project

New triterpenes with antitumor activity - synthesis, activity, study of the mechanism of action (GA21-00902S)

synthesis and on signalling pathways using lentiviral reporters. The best candidates will be studied for their biological targets using fluorescent and Raman microscopy, pull down......

Organic chemistry

  • 2021 - 2024
    • •
  • 6 996 tis. Kč
    • •
  • 6 996 tis. Kč
    • •
  • GA ČR
Project

Biomedical model of miniature pigs for testing of new medicaments and for new treatments of traumatic spinal cord injury and neurodegenerative diseases (TA01011466)

of lentiviral vectors for mutated huntingtin. All biomedical models will be offered...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2014
    • •
  • 22 639 tis. Kč
    • •
  • 18 033 tis. Kč
    • •
  • TA ČR
Project

Mitochondrial DNA genetics in relation to mitochondrial network dynamics and pathogenesis (GAP305/12/1247)

will be employed. Mt nucleoids will be visualized by lentivirally transfected conjugates...

EB - Genetika a molekulární biologie

  • 2012 - 2016
    • •
  • 7 635 tis. Kč
    • •
  • 7 635 tis. Kč
    • •
  • GA ČR
Project

Pathophysiology and Natural Course of Primary Antibody Deficiency (PAD) Syndromes (7E08062)

The project will document and monitor the natural course and study the pathophysiology of Primary Antibody Deficiencies (PAD). PADs are rare inborn errors of the immune system with an estimated incidence of <1:25.000. The defective immunity in patien...

EC - Imunologie

  • 2008 - 2011
    • •
  • 578 tis. Kč
    • •
  • 578 tis. Kč
    • •
  • MŠMT
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