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Mechanical properties of RNA and DNA structural building blocks (GA17-14683S)
Natural and artificial RNA and DNA structures are composed of recurrent to a multidimensional forced deformation free energy method. We will investigate the effect of cytosine methylation on DNA mechanics, and DNA ...
BO - Biofyzika
- 2017 - 2021 •
- 4 017 tis. Kč •
- 3 756 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (94%)
Poskytovatel: Grantová agentura České republiky
Nanomechanics of RNA and DNA structural motifs (GA14-21893S)
RNA and DNA motifs are recurrent structural building blocks found dynamics (MD) simulation data of selected RNA and DNA molecules. We will adopt (notably C-loops), bulges, and three-way junctions will be studied. DNA double...
BO - Biofyzika
- 2014 - 2016 •
- 2 668 tis. Kč •
- 2 668 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2014 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Interactions of organometallic antitumor compounds with nucleic acids and proteins study of sequence and substrate selectivity (GAP208/12/0622)
on transition states' (de)stabilizations and their sequence dependence, course of local a binding to DNA as a key step of their antitumor activity. It leads to a modification of DNA structure and changes of its in...
CF - Fyzikální chemie a teoretická chemie
- 2012 - 2015 •
- 5 435 tis. Kč •
- 5 435 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Interactions of p53 family proteins with biologically significant DNA quadruplexes (GA13-36108S)
of p53 interaction with DNA. Human genome is enriched in DNA sequences with G-quadruplex-forming potential (repetitive sequences, oncogene promoters and 5´UTRs mRNATumor suppressor function of p53, p63 and p73 pro...
EB - Genetika a molekulární biologie
- 2013 - 2015 •
- 4 919 tis. Kč •
- 4 919 tis. Kč •
- GA ČR
Řešení projektu: 1. 2. 2013 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
DNA quadruplexes in the human genome associated with diseases and aging (GAP205/12/0466)
is the oct4 gene, which contains a DNA sequence in the promotor region that is capable and the mutations that increase or reduce their stability. We will analyze the dependence of their formation on differences in DNA<...
BO - Biofyzika
- 2012 - 2016 •
- 5 753 tis. Kč •
- 5 753 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Positional cloning of rat hypodactyly - a mutation causing male infertility and limb deformity (GA301/02/0464)
DNA markers on segregating intercross (F2) and backcross progenies and radiation available large-insert genomic DNA libraries. Candidate genes can be also unraveled by database searching for rat or homologous mouse and human se...
EB - Genetika a molekulární biologie
- 2002 - 2004 •
- 1 970 tis. Kč •
- 1 970 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2002 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Industrial research and development of new DNA technology for human diagnostics next generation sequencing and microRNA (EG15_018/0004701)
Industrial research and development of new DNA technology for human diagnostics: next generation sequencing and microRNA...
FS - Lékařská zařízení, přístroje a vybavení
- 2015 - 2020 •
- 19 337 tis. Kč •
- 2 141 tis. Kč •
- MPO
Řešení projektu: 29. 9. 2015 - 11. 6. 2020
Uznané náklady
Podpora ze státního rozpočtu (11%)
Poskytovatel: Ministerstvo průmyslu a obchodu
Novel anti-Stokes lanthanide nanoparticles and multicolor FRET mechanisms for single-molecule DNA sequencing (GF23-06199K)
DNA sequencing is a key technology for the life sciences and clinical diagnosis) that have a genetic component. Although a few DNA sequencing methods exist, detecting out DNA sequences continuousl...
Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])
- 2023 - 2025 •
- 6 525 tis. Kč •
- 6 525 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2023 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Research and development of a new type of electrochemical biosensor for the detection of nucleotide sequences in DNA and of genotoxic agents in the environment. (1H-PK/42)
At present there is an increasing interest in devices (sensors, chips, etc.) suitable for rapid detection of a large number of nucleotide sequences in DNA and RNA, based on optical methods. It is the intention of this project to com...
EI - Biotechnologie a bionika
- 2004 - 2007 •
- 14 864 tis. Kč •
- 7 403 tis. Kč •
- MPO
Řešení projektu: 1. 9. 2004 - 30. 6. 2007
Uznané náklady
Podpora ze státního rozpočtu (50%)
Poskytovatel: Ministerstvo průmyslu a obchodu
Investigation of plant repetitive DNA by bioinformatic analysis of next-generation sequencing data (OC10037)
DNA sequencing is one of the basic techniques of genome investigation. However, relatively low speed and high cost of sequencing projects employing traditional, clone-based Sanger sequencing represent limiting fact...
EB - Genetika a molekulární biologie
- 2010 - 2012 •
- 3 116 tis. Kč •
- 1 494 tis. Kč •
- MŠMT
Řešení projektu: 1. 5. 2010 - 31. 12. 2012
Uznané náklady
Podpora ze státního rozpočtu (48%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
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