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36 (0,21s) •

Project

Identification of new molecules that are able to interact with allosteric binding sites on purinergic P2X receptors (GA18-05413S)

by a variety of allosteric modulators, including neurosteroids. The aim of the proposed project is to test several classes of neurosteroids, including sex steroids and neurosteroids previously shown to affect NMDA and GABA...

Neurosciences (including psychophysiology)

  • 2018 - 2020
    • •
  • 5 937 tis. Kč
    • •
  • 5 424 tis. Kč
    • •
  • GA ČR
Project

Neurosteroids - a risk factors of some brain diseases? (1A8637)

We will determine the activities of steroidogenic enzymes (mainly sulfatase and sulfotransferase) in human brain tumorous tissues obtained during necessary surgical operation. Moreover we will determine spectrum of neurosteroids and aminothi...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2005 - 2007
    • •
  • 2 114 tis. Kč
    • •
  • 2 096 tis. Kč
    • •
  • MZ
Project

Role of neuroactive steroids in mechnanism of action of clozapine (NU20-04-00389)

In our previous projects, we have demonstrated the role of neurosteroids of studies suggest that different levels of neurosteroids may explain differences in the therapeutic response. Antipsychotics can normalize altered levels of <...

Psychiatry

  • 2020 - 2023
    • •
  • 18 948 tis. Kč
    • •
  • 18 948 tis. Kč
    • •
  • MZ
Project

Synthetic analogues of neurosteroids with activity on membrane receptors (IAA4055305)

Neurosteroids alter the course of many psychiatric and neurologic disordes. Similar compounds with konger biological half-life could be useful in the treatment of such illinesses. We prepared a series of compounds more water soluble and more...

CC - Organická chemie

  • 2003 - 2007
    • •
  • 3 635 tis. Kč
    • •
  • 2 828 tis. Kč
    • •
  • AV ČR
Project

Neurosteroid modulation of NMDA receptors (GAP303/12/1464)

occurring neurosteroids with inhibitory (20-oxo-5&beta;-pregnan-3&alpha;-yl for the PAS effect; (ii.) characterize the structural properties the neurosteroid molecule......

ED - Fyziologie

  • 2012 - 2016
    • •
  • 18 904 tis. Kč
    • •
  • 18 904 tis. Kč
    • •
  • GA ČR
Project

Extraovarian steroid hormones in the course of the menstrual cycle (NT12340)

with food intake; the significance of neurosteroids in food intake is noted. We of neurosteroids. We will monitor the course of changes in the studied hormones in various......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2011 - 2015
    • •
  • 5 549 tis. Kč
    • •
  • 5 549 tis. Kč
    • •
  • MZ
Project

Study of the effects of neurosteroids on ionotropic glutamate receptors and synaptic transmission (GA309/04/1537)

the effects of two structurally similar and endogenously occurring neurosteroids: 20 on theactivity of NMDA receptor channels. The mechanisms of neurosteroid action......

FH - Neurologie, neurochirurgie, neurovědy

  • 2004 - 2006
    • •
  • 3 103 tis. Kč
    • •
  • 3 103 tis. Kč
    • •
  • GA ČR
Project

Synthesis and evaluation of neurosteroids as possible antiepileptics (IBS5011007)

New types of compounds, capable of binding to the steroid site of GABA-A receptor supramolecular complex, will be synthesized. Anticonvulsant action of these compounds will be tested against motor seizures induced by pentylenetetrazol in adulst rats....

CC - Organická chemie

  • 2000 - 2004
    • •
  • 4 397 tis. Kč
    • •
  • 2 085 tis. Kč
    • •
  • AV ČR
Project

Molecular, cellular, and behavioral effects of NMDA receptor-modulating steroids (GA17-02300S)

occurring neurosteroid pregnenolone sulfate and its synthetic analogues will be to: (i.) characterize the mechanism by which neurosteroids exert their positive......

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2021
    • •
  • 7 914 tis. Kč
    • •
  • 7 161 tis. Kč
    • •
  • GA ČR
Project

Synaptic Effects and Neuroprotective Properties of NMDA Receptor-Modulating Neurosteroids (GJ16-03913Y)

. Endogenous neurosteroid pregnanolone sulfate (PA-S) inhibits NMDARs in a use-dependent...

ED - Fyziologie

  • 2016 - 2020
    • •
  • 4 509 tis. Kč
    • •
  • 4 509 tis. Kč
    • •
  • GA ČR
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