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Novel CB2 and BChE modulators against Parkinson's disease and related pathologies (GA23-05389S)
targeting both cannabinoid receptor 2 (CB2) and butyrylcholinesterase (BChE), which targeting CB2 and BChE and the study of their neuroprotective and anti-neuroinflammatory information on the mechanism of action of dual CB2-BCh...
Biochemistry and molecular biology
- 2023 - 2025 •
- 9 897 tis. Kč •
- 9 897 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2023 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Non-specific and versatile cholinesterase reactivators to countermeasure organophosphorus intoxication (GA22-05318S)
against both cholinesterases AChE and butyrylcholinesterase (BChE) inhibited in vitro on both enzymes AChE and BChE. Two most versatile compounds......
Analytical chemistry
- 2022 - 2024 •
- 10 378 tis. Kč •
- 10 378 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
DENPL - Replacement devices for highly sensitive detection NPA GSA-12 (OWVVU20160004)
The main objective of the project is to design, to fabricate and to test a functional sample of sensitive detector of nerve agents based on the principle of biochemical reaction, which promisingly fully replace obsolete Russian-made detector GSA-12. ...
KA - Vojenství
- 2016 - 2018 •
- 8 087 tis. Kč •
- 8 087 tis. Kč •
- MO
Řešení projektu: 1. 6. 2016 - 31. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo obrany
The concept of organophosphate-inhibited non-selective cholinesterase reactivators (LUAUS23275)
reactivation (AChE, BChE or both). We expect to develop at least 30 different functionally of inhibition to native AChE/BChE enzymes, iii) prediction of passage through biological......
Other medical science
- 2023 - 2027 •
- 9 736 tis. Kč •
- 9 736 tis. Kč •
- MŠMT
Řešení projektu: 1. 3. 2023 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Development of diagnostic kits for the prediction of the disorders of myorelaxans metabolism at anesteziology and intensive medicine (TH04010116)
The purpouse of this project is to develop within 3 years IVD kits for genetic testing of poor metabolizers (PM) of a general myorelaxant Suxamethonium. It is often used because of it's low cost and suitable pharmacodynamic profile. For patients who,...
Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])
- 2019 - 2022 •
- 21 800 tis. Kč •
- 13 048 tis. Kč •
- TA ČR
Řešení projektu: 1. 1. 2019 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (60%)
Poskytovatel: Technologická agentura ČR
Hybrid structures based on Amiridine as potential multitarget drugs for Alzheimer's disease treatment (GC20-29633J)
Amiridine is anticholinesterase drug used in Russia for treatment of Alzheimer´s disease and a number of other neurological disorders., It is an inhibitor of AChE and BChE, it restores fatty acid and phospholipid metabolism, normalizes the p...
Pharmacology and pharmacy
- 2020 - 2022 •
- 4 809 tis. Kč •
- 4 809 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2020 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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