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2 849 (0,09s) •

Project

Regulation of posttranscriptional gene silencing in transgene plants (GP521/01/P042)

The aim of the proposed project is to study posttrancriptional gene silencing in transgenic plants. Tobacco lines containing a neomycin phosphotransferase II reporter gene (nptll) and showing variable degree of its sile...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 1 319 tis. Kč
    • •
  • 700 tis. Kč
    • •
  • GA ČR
Project

Transcriptional silencing of retroviral vectors during their integration into the host genome (GP301/09/P667)

in gene therapy. Silencing of retroviral vectors is observed in two experimentalThe transcriptional silencing of retroviral vectors represents major complication of efficient gene transfer in gene therapy...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • GA ČR
Project

The role of epigenetic factors in regulation of gene expression in higher plants (GA521/01/0037)

We propose to study epigenetic gene silencing in higher plants using Nicotiana tabacum as a model organism. Several tobacco lines carrying transgenic loci (T-DNA) will be analysed with respect to gene expression, type and d...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 8 198 tis. Kč
    • •
  • 2 798 tis. Kč
    • •
  • GA ČR
Project

Deciphering the relationship between homologous recombination and gene silencing (GA23-05284S)

integrating transcriptional, chromatin, and molecular analyses to show that gene silencing understanding of their link to gene silencing is of utmost importance.. Recently, an intriguing connection between homolog...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 7 260 tis. Kč
    • •
  • 7 260 tis. Kč
    • •
  • GA ČR
Project

Regulation of heterochromatic gene silencing (GA15-23165S)

underlying heterochromatic gene silencing has provided unique insight and opportunity place within our silencing model. Together these studies will provide a more concrete understanding of the mechanisms that control heter...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 7 818 tis. Kč
    • •
  • 7 818 tis. Kč
    • •
  • GA ČR
Project

Epigenetic regulation of gene expression in transgenic and endogenous loci of higher plants (GA521/04/0775)

and gene silencing has been described in both mammals and plants. We propose to carry in posttranscriptionally silenced transgenic loci of Nicotiana tabacum that occured in cell culture. Several novel epiallalelic variants...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 2 998 tis. Kč
    • •
  • 2 998 tis. Kč
    • •
  • GA ČR
Project

Structural basis of gene silencing (GA304/06/1662)

of Polycomb (PcG) and Trithorax (TrxG) group gene silencing proteins using advanced light that loci silenced by PcG proteins are spatially interspersed among transcriptionally active genes rather than they are rep...

EA - Morfologické obory a cytologie

  • 2006 - 2008
    • •
  • 5 051 tis. Kč
    • •
  • 4 855 tis. Kč
    • •
  • GA ČR
Project

Targeted gene silencing using siRNAs in primary cell cultures of CML patients and leukemic cell lines (K562, MOLM-7, KU-812) (NR7989)

In the project siRNAs will be used for gene expression silencing of the genes MMP8,MMP9,PCNA,MAPK p38,Bmi-1,BCR/ABL in CML-derived leukemic cell lines and in primary cultures obtained with cultivation of peripheral blood le...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 3 699 tis. Kč
    • •
  • 3 291 tis. Kč
    • •
  • MZ
Project

Mendelian and non-mendelian interactions of the plant transgenes (IAA600040611)

asinverted repeat whose reporter gene is silenced either at the posttranscriptional will be focused on inheritance and silencing properties of epiallelic variants of transgenes silencing types and contributions of...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 1 415 tis. Kč
    • •
  • 1 415 tis. Kč
    • •
  • AV ČR
Project

Embryonic gene expression and posttranscriptional gene silencing during bovine preimplantation development (GA523/09/1035)

silencing of selected genes using double-stranded RNA (dsRNA) and find out whether of silenced andcontrol embryos on microarrays will identify downstream genes of silenced areused, we can obtained  number...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 3 342 tis. Kč
    • •
  • 3 342 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 2 849