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The presence of Prion and Cellular Prion Protein in Blood Optimalization of Detection Methods (NI7416)
The project objective is characterization of cellular prion protein present in different components of blood and utilization of this kowledge in a selection of strategies for optimal detection of infectious prion in tblood. The resu...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2003 - 2005 •
- 1 649 tis. Kč •
- 1 649 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2003 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
The role of cellular prion protein in erythroid differentiation possible link to peripheral pathogenesis of prion diseases (GA310/08/0878)
Transmissible spongiform encephalopathies (TSE) or prion diseases are fatal degenerative neurological disorders of mammals. Four recent transmissions of human TSE infection by transfusion highlight the need for detailed understanding of bloo...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2008 - 2012 •
- 8 342 tis. Kč •
- 8 342 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2008 - 31. 12. 2012
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Cell culture for propagation of prions influence of cell culture proliferation and expression of endogenous retroviruses (GP310/09/P260)
or prion diseases, is the misfolding of cellular prion protein - PrPc into infectious experimental systems for analyzing the molecular and cellular mechanisms of prion propagation. Prion propagation in cell cultur...
EE - Mikrobiologie, virologie
- 2009 - 2011 •
- 1 629 tis. Kč •
- 1 629 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The role of cellular prion protein (PrPc) expression on blood cells (GA310/04/0419)
Transmissible Spongiphorm Encephalopathies (TSE) or prion diseases by transfusion succeeded manifest deficiencies in the expression of cellular prion protein on platelets and RBC serves as a receptor for infectious prion an...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2004 - 2006 •
- 4 326 tis. Kč •
- 3 862 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (89%)
Poskytovatel: Grantová agentura České republiky
Chemical syntheses of fluorescence labeled mouse prion proteins using chemical ligations and investigation of their properties (GA203/07/1517)
prion protein in the brain. In our project we are going to carry out chemical synthesis of Mouse Prion Protein (32-230) - precursor of TSE causative agent - and some as,to explore the ability of prion protein to interact w...
CC - Organická chemie
- 2007 - 2011 •
- 6 638 tis. Kč •
- 6 638 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2007 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
New possibilities of intravital diagnostics of prion diseases from peripheral tissues and cerebrospinal fluid. (NV18-04-00179)
Prion diseases are fatal neurodegenerative disorders connected with accumulation of aggregated misfolded prion protein in the brain of affected individuals) assay, for intravital diagnostics of prion diseases. The method al...
Clinical neurology
- 2018 - 2021 •
- 12 219 tis. Kč •
- 12 219 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2018 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Combinatorial approach to myelin and/or beta-sheet breakers. Implication for the therapeutic approaches to Alzheiner's and prion diseases (GA203/02/1379)
fragment fromhuman prion protein (HuPrP106-26) which is able of the aggregation similarly to prion proteins in sick organisms. In the biological and physico-chemical attempt to find out if any of select compounds prepared is able t...
CC - Organická chemie
- 2002 - 2004 •
- 1 840 tis. Kč •
- 1 327 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2002 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (72%)
Poskytovatel: Grantová agentura České republiky
Detection of prion protein in blood and cerebral spinal fluid of patients with Creutzfeldt-Jakob disease (NS10335)
Very little is known about the nature of prions in blood. Detection of pathological prion protein (PrPtse) in blood is complicated by the presence of substantial amount of cellular prion protein (PrPc) and by unavailability...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2009 - 2011 •
- 5 116 tis. Kč •
- 5 116 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
The role of proteinase-activated receptors in pathogenesis of prion diseases (GAP303/12/1791)
Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal neurodegenerative disorders of men and animals. The hallmark of TSEs is accumulation of misfolded form of prion protein in the brain of affected subjects. ...
FH - Neurologie, neurochirurgie, neurovědy
- 2012 - 2016 •
- 12 843 tis. Kč •
- 12 843 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Development and Utilization of Anti- Prion Monoclonal Antibodies for Detection of PrPtse/PrPc in Cell Cultures and Blood (MEB091004)
1. Utilize different anti-PrP mAbs, developed by the Slovene partner for the detection of different strains of PrPtse in prion infected mouse cell cultures of neuronal or fibroblast origin in different stages of cell division provided by #OR...
EE - Mikrobiologie, virologie
- 2010 - 2011 •
- 112 tis. Kč •
- 112 tis. Kč •
- MŠMT
Řešení projektu: 1. 1. 2010 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
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