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5 (0,04s)

Project

Novel pathways of FGFR3 signaling in achondroplasia (GA301/09/0587)

Activating mutations in the FGFR3 tyrosine kinase account for several forms of human dwarfism, including achondroplasia, the most common form of human short-limb dwarfism, and a neonatal-lethal thanatophoric dysplasia. Although achondroplasia is cons...

EB - Genetika a molekulární biologie

  • 2009 - 2011
  • 2 850 tis. Kč
  • 2 850 tis. Kč
  • GA ČR
Project

Prospective multiparametric MRI monitoring of the knee joint hyaline cartilage after implantation of biological collagen type I matrix implants (NV16-30833A)

Magnetic resonance (MR) is a method very well suited to monitoring changes in hyaline cartilage and can be used to diagnose impairment in such cartilage. In indicated cases, local chondral changes are resolved through orthopaedic surgery – either usi...

FP - Ostatní lékařské obory

  • 2016 - 2020
  • 5 078 tis. Kč
  • 5 038 tis. Kč
  • MZ
Project

Identification of novel therapeutic approaches to achondroplasia via analysis of FGFR3 interaction with adapter protein Frs2 (NV15-33232A)

Activating mutations in fibroblast growth factor receptor 3 (FGFR3) account for the most prevalent form of dwarfism in humans, the achondroplasia. Excessive activation of FGFR3 causes premature chondrocyte growth arrest, abnormal extracellular matrix...

EB - Genetika a molekulární biologie

  • 2015 - 2018
  • 9 730 tis. Kč
  • 9 730 tis. Kč
  • MZ
Project

Using phosphodiesterases to therapeutical manipulation of bone and cartilage cells (NU21-06-00512)

Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) are used as second messengers by many signaling pathways. In bone, cAMP mediates signaling induced especially by parathormone and parathyroid hormone-related protein (PTH...

Orthopaedics

  • 2021 - 2025
  • 11 082 tis. Kč
  • 11 027 tis. Kč
  • MZ
Project

Ultrasonography of joints in children with juvenile idiopathic arthritis Assessment of subclinical synovitis and joint damage (NV16-33002A)

Hypothesis: The identification of subclinical synovitis and structural damage in the joints by musculoskeletal ultrasonography (MSUS) in children with juvenile idiopathic arthritis (JIA) will contribute to the monitoring and optimizing of therapy wit...

FG - Pediatrie

  • 2016 - 2021
  • 3 193 tis. Kč
  • 2 755 tis. Kč
  • MZ
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