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662 (0,103s)

Project

Transport of cations and protons across biomembranes - molecular structure and activity mechanism of Na+/H+ antiporters from lower eukaryots II (LD13037)

The aims of the project are to compare the properties of antiporters from different yeast species and to finish a model of transport mechanism via Na+/H+ antiporters in lower eukaryotes.......

EB - Genetika a molekulární biologie

  • 2013 - 2013
  • 753 tis. Kč
  • 401 tis. Kč
  • MŠMT
Project

Functional analysis of amino acid residues essential for the substrate specificity of yeast Na+/H+-antiporters (GP204/02/D092)

Na+/H+-antiporters are secondary active transport systems occurring in almost all types of cells. The family of homologous yeast plasma membrane Na+/H will be identified (i) by mutagenesis of Z. rouxii

EB - Genetika a molekulární biologie

  • 2002 - 2005
  • 718 tis. Kč
  • 718 tis. Kč
  • GA ČR
Project

Eukaryotic Na+/H+ antiporters – key elements in their structure determining activity, biogenesis and physiological functions (GA21-08985S)

Saccharomyces cerevisiae as a model organism, we will study Na+/H+ antiporters from+/H+ antiporters and the biogenesis of human Na+/H+ antiporters, but will alsoAll biological p...

Biochemistry and molecular biology

  • 2021 - 2024
  • 5 956 tis. Kč
  • 5 956 tis. Kč
  • GA ČR
Project

Role of Na/H antiporters in cell physiology - yeast as a model organism for expression and characterization (IAA5011407)

Yeast Na/H antiporters forms 2 subfamilies: first one has a role results will contribute to our knowledge of the physiological role of Na/H antiporters superfamily of Na/H an...

EB - Genetika a molekulární biologie

  • 2004 - 2007
  • 1 851 tis. Kč
  • 1 851 tis. Kč
  • AV ČR
Project

Role of Na/H antiporters in the physiology of yeast cells (IAA5011005)

for sodium efflux is a Na-ATPase, wheareas the Na/H antiporter seems to be involved in sodium efflux only marginally. On the other hand, Na/H antiporters are the main. rouxii) yeasts. Ev...

EB - Genetika a molekulární biologie

  • 2000 - 2002
  • 2 443 tis. Kč
  • 997 tis. Kč
  • AV ČR
Project

Transport of cations and protons across biomembranes - molecular structure and activity mechanism of Na+/H+ antiporter from lower eukaryotes (OC10012)

The aims of the project are 1) to elucidate the molecular structure of a yeast S. cerevisiae plasma-membrane Na+/H+ antiporter transporting alkali metal cations in exchange of protons, 2) to identify amino-acid residues and...

CE - Biochemie

  • 2010 - 2012
  • 3 205 tis. Kč
  • 1 442 tis. Kč
  • MŠMT
Project

Characterizeation of Na+/H+ antiporters from Debaryomyces hansenii and Yarrowia lipolytica (GA206/05/0035)

of the transporters involved in osmotolerance is a plasma membrane Na/H antiporter. Though the alkali-metal-cation/H antiporters represent conserved family existing in almost all diverged during evolution...

EE - Mikrobiologie, virologie

  • 2005 - 2007
  • 1 508 tis. Kč
  • 1 508 tis. Kč
  • GA ČR
Project

Role of Na/H antiporters in cell physiology - transporters teamwork in intracellular pH and K+ homeostasis (IAA500110801)

Na+/H+ antiporters serve in all organisms mainly to maintain intracellular homeostasis of alkali metal cations and pH. In the model yeast Saccharomyces cerevisiae in the Golgi apparatus and the Nhx1 antiporter is l...

EB - Genetika a molekulární biologie

  • 2008 - 2012
  • 4 020 tis. Kč
  • 4 020 tis. Kč
  • AV ČR
Project

Functional study of the Na+, K+/H+antiporter Cnh1p in the pathogenic yeast Candida albicans (KJB5011307)

Intracellular pH and K+ content belong among factors controlling morphology of a diploid fungus Candida albicans. The C. albicans CNH1 gene encodes a Na+/H+-antiporter with substrate specificity for four alkalimetal cations...

EB - Genetika a molekulární biologie

  • 2003 - 2004
  • 597 tis. Kč
  • 329 tis. Kč
  • AV ČR
Project

Studies of mitochondrial NA+/CA2+ antiporter (1P05ME796)

characterisation of phanotype of mitichondrial NA+/CA2+ antiporte, characterisation of mitochondrial ATP-sensitive potassium chanel and its role in protection of heart against ischemia......

ED - Fyziologie

  • 2005 - 2008
  • 2 624 tis. Kč
  • 1 312 tis. Kč
  • MŠMT
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