All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

1 085 (0,138s) •

Project

Regulation of NMDA receptor trafficking and function by N-glycosylation (GA14-02219S)

N-methyl-D-aspartate (NMDA) receptors play critical roles in glutamatergic that the abnormal regulation of NMDA receptors underlies a wide variety of neurological receptors are N-glycosylated, the effect o...

FH - Neurologie, neurochirurgie, neurovědy

  • 2014 - 2016
    • •
  • 5 123 tis. Kč
    • •
  • 5 123 tis. Kč
    • •
  • GA ČR
Project

Structural and functional determinants of NMDA receptor trafficking (GP14-09220P)

N-methyl-D-aspartate (NMDA) receptors mediate fast excitatory synaptic is to elucidate mechanisms determining trafficking of NMDA receptors. Using intracellular processing and surface delivery of NMDA ...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 2 218 tis. Kč
    • •
  • 2 218 tis. Kč
    • •
  • GA ČR
Project

Neurosteroid modulation of NMDA receptors (GAP303/12/1464)

The N-methyl-D-aspartate (NMDA) subtype of glutamate receptors mediates at NMDA receptors. The aim of the project will be to: (i.) identify the route by which PAS accesses the NMDA receptor and id...

ED - Fyziologie

  • 2012 - 2016
    • •
  • 18 904 tis. Kč
    • •
  • 18 904 tis. Kč
    • •
  • GA ČR
Project

Synthesis and activity evaluation of NMDA receptor antagonists (GA203/08/1498)

N-Methyl-D-aspartate (NMDA) receptors play a critical positive role. Endogenous neurosteroid ligands selectively affect the NMDA receptors. We intend and derivatives with an anionic chain. Such compounds should be ...

CC - Organická chemie

  • 2008 - 2010
    • •
  • 2 187 tis. Kč
    • •
  • 2 187 tis. Kč
    • •
  • GA ČR
Project

Role of the cytoplasmic domain of the NMDA receptor for its biogenesis, function, and pharmacology Focus on disease-associated mutations (GA20-17945S)

of the intracellular C-terminal domain (CTD) in the regulation of NMDA receptor biogenesis mutations for the biogenesis, function and pharmacology of triheteromeric NMDA receptors, and (iii) effects of human disea...

Neurosciences (including psychophysiology)

  • 2020 - 2022
    • •
  • 10 108 tis. Kč
    • •
  • 10 041 tis. Kč
    • •
  • GA ČR
Project

Role of membrane domains of NR1 and NR2 subunits in the assembly and trafficking of the NMDA receptor to the cell surface (GAP303/11/0075)

N-methyl-D-aspartate (NMDA) receptors mediate fast excitatory synaptic transmission in the mammalian central nervous system. Activation of NMDA receptors can to the formation of functional NMDA recepto...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2013
    • •
  • 4 160 tis. Kč
    • •
  • 4 160 tis. Kč
    • •
  • GA ČR
Project

Study of the effects of neurosteroids and temperature on NMDA receptors (GA309/07/0271)

N-methyl-D-aspartate (NMDA) subtype of glutamate receptors mediates the fast effext at NMDA receptors), (ii.) elucidate cellular mechanisms involved-3ß-yl sulfate (PS; neusteroid that has a potentiating effect at <...

FH - Neurologie, neurochirurgie, neurovědy

  • 2007 - 2011
    • •
  • 6 660 tis. Kč
    • •
  • 6 660 tis. Kč
    • •
  • GA ČR
Project

The effect of cell membrane fluidity on the functional properties of NMDA receptors (GPP303/11/P391)

N-methyl-D-aspartate (NMDA) receptor is a ionotropic glutamate receptor, whose on the relation of cholesterol and NMDA receptors. The main objective is to describe depletion induced significant increase in...

ED - Fyziologie

  • 2011 - 2015
    • •
  • 2 195 tis. Kč
    • •
  • 2 195 tis. Kč
    • •
  • GA ČR
Project

The role of neuroactive steroids in the disorders of nervous system (NB6691)

The method of determination of pregnanolones and their conjugates will be developed. The levels of steroid modulators of GABA and NMDA receptors will be evaluated in controls, epileptic women during menstrual cycle and in patients w...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 3 946 tis. Kč
    • •
  • 3 320 tis. Kč
    • •
  • MZ
Project

Physiological and pathological potential of astroglial NMDA receptors (GA309/08/1381)

Astroglial NMDA receptors were discovered only very recently. These receptors are detected in the spinal cord and in the cortex and are potentially important for the integration in neuronal-glial circuits. This project will...

FH - Neurologie, neurochirurgie, neurovědy

  • 2008 - 2012
    • •
  • 7 068 tis. Kč
    • •
  • 7 068 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 1 085