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9 531 (0,13s) •

Project

Targeted inhibition of BCL2 family proteins in experimental therapy of diffuse large B-cell lymphoma (DLBCL) (NV15-27757A)

Diffuse large B-cell lymphoma (DLBCL) represents the most prevalent type of non-Hodgkin lymphomas (NHL) in the Western hemisphere. BCL2 and MCL1 belong to key clinically in diverse B<...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 6 991 tis. Kč
    • •
  • 6 991 tis. Kč
    • •
  • MZ
Project

Identification of novel risk factors and molecular mechanisms of central nervous system relapse in diffuse large B-cell lymphoma (NU23-03-00127)

Central nervous system (CNS) relapse in diffuse large B-cell lymphoma (DLBCL molecular mechanisms that enable lymphoma cell evasion and survival in CNS. We will compare genetic a...

Hematology

  • 2023 - 2026
    • •
  • 14 404 tis. Kč
    • •
  • 14 404 tis. Kč
    • •
  • MZ
Project

Diffuse large B-cell and follicular lymphoma - the analysis of prognostic factors and therapeutic strategies on patient´s outcome; Lymphoma Project in the Czech Republic. (NT12193)

The aim of the project is to characterize the outcome of patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in the Czech Republic will be performed on Czech ...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 6 992 tis. Kč
    • •
  • 6 864 tis. Kč
    • •
  • MZ
Project

Correlation of molecular biological, immunohistochemical and clinical characteristics of diffuse large B cell lymphoma in terms of diagnostical and prognostic algorithm. (NS9791)

Retrospectively, the expression of selected genes in patients with DLBCL will be studied from FFPE (formalin fixed, paraffin embedded) tissue. The results will be compared with immunohistochemical findings (GC and nonGC subtypes) and with cl...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 4 569 tis. Kč
    • •
  • 4 569 tis. Kč
    • •
  • MZ
Project

Advanced molecular testing for aggregate diagnosis and management of DLBCL patients engagement of gene expression profiling, liquid biopsy and long-read sequencing (NU22-08-00227)

Diffuse large B-cell lymphoma (DLBCL) is the most common adult type of non-Hodgkin lymphomas characterized by significant heterogeneity in clinicopathologic objectives in DLBCL c...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2022 - 2025
    • •
  • 12 741 tis. Kč
    • •
  • 12 741 tis. Kč
    • •
  • MZ
Project

Molecular Aspects of B-cell Receptor Signal Initiation as Targets for Specific Therapy of non-Hodgkin Lymphoma. (NV18-03-00117)

chemotherapy combination over 40 years old. The B-cell receptor (BCR) inhibition is such emerging therapy applicable to various B-cell derived NHL, which were shown to use) and “tonic” (analogous to baseline BCR s...

Oncology

  • 2018 - 2022
    • •
  • 11 156 tis. Kč
    • •
  • 11 156 tis. Kč
    • •
  • MZ
Project

Complex analysis of p53 mutants in lymphoproliferative diseases (NT13784)

We propose to perform complex analysis of the p53 tumor suppressor in tumor tissues of MCL and DLBCL patients aiming to extend existing panels of patients (from 42 to 70 in MCL and from 75 to 140 in DLBCL) and to determine the progn...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 4 104 tis. Kč
    • •
  • 4 104 tis. Kč
    • •
  • MZ
Project

The analysis of molecular subtypes of diffuse large B-cell lymphoma by high-resolution arrayCGH for determination of genetic changes of prognostic importance (NT11103)

The study of genetic changes in cells of the tumor genome of patients with DLBCL using the array CGH, Q-RT-PCR and immunohistochemistry methods to acquire and the FOXP1 gene, chromosome 8 and the CMYC gene, and chromosome 18q and th...

FD - Onkologie a hematologie

  • 2010 - 2014
    • •
  • 6 499 tis. Kč
    • •
  • 6 479 tis. Kč
    • •
  • MZ
Project

Complex analysis of p53 tumor suppressor in non-Hodgkin´s lymphomas (NR9305)

The aim of this project is complex analysis of tumor suppressor p53 in tumor tissue of patients with diffuse large B-cell lymphoma and mantle cell lymphoma to verify whether p53 abberatio...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 2 494 tis. Kč
    • •
  • 2 494 tis. Kč
    • •
  • MZ
Project

Therapy intensification of patients with Diffuse Large B Cell Lymphomas based on early FDG-PET positivity (prospective analysis) and retrospective evaluation of the changes in lymphoma therapy (NR9453)

-PET evaluation in young patients with diffuse larg B-cell lymphoma with lowThe aim of the project is the analysis of different lymphoma subgroups (follicular, marginal zone, peripheral T cell...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 6 575 tis. Kč
    • •
  • 6 360 tis. Kč
    • •
  • MZ
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