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4 721 (0,168s) •

Project

Role of DNA conformation and DNA grooves in protein - DNA recognition. Model studies. (GA204/96/0287)

governing the specific and selective binding of proteins to DNA with a special regard of the complex. Peptides modelling the specific protein binding sites (i.e. the binding motif of the bZIP

CE - Biochemie

  • 1996 - 1998
    • •
  • 747 tis. Kč
    • •
  • 480 tis. Kč
    • •
  • GA ČR
Project

Binding of tumor suppressor protein p53 to DNA. Effect of DNA supercoling and protein postsynthetic modification (IAA4004110)

protein p53 and its binding to DNA. Better understanding of this key protein of the complex p53 protein molecules and on p53 binding to DNA. are directed at: (i) the effect of postsynthe...

CE - Biochemie

  • 2001 - 2004
    • •
  • 4 874 tis. Kč
    • •
  • 1 990 tis. Kč
    • •
  • AV ČR
Project

Influence of DNA superhelicity on sequence specific and structure selective binding of the p53 protein (GP301/04/P025)

play crucial role in p53 protein function. DNA protein binding is often to study binding of the p53 protein to these structures stabilized by DNA supercoiling p53 binding to set...

CE - Biochemie

  • 2004 - 2006
    • •
  • 720 tis. Kč
    • •
  • 720 tis. Kč
    • •
  • GA ČR
Project

Regulation of transcription factors binding to consensus sequences in superhelical DNA. Influence of phosphorylation of tumor supressor proteins (IAB5004203)

for semiquantitative testing of the effect of the DNA supercoiling on protein binding and technique of supershifting of specific protein /DNA complexes by monoclonal antibodies. The effect assay for testi...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 3 400 tis. Kč
    • •
  • 1 080 tis. Kč
    • •
  • AV ČR
Project

Mutants of tumor supressor protein p53 and regulation of thei DNA binding activity (KJB500040502)

shift retardation method we will analyze protein/DNA complexes in agarose and/or acrylamide gel. We will examine the possibility of activation p53 mutants to DNA bindingThe p53 tumor suppressor protein pl...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • AV ČR
Project

Targeting DNA interactions with platinum anticancer drugs with damaged-DNA binding-proteins (LH13096)

with damaged-DNA binding-proteins. The major motivation for formulation of this aim proteins. (3) Correlation between DNA binding modes (including resulting conformational distortions, their reco...

CA - Anorganická chemie

  • 2013 - 2015
    • •
  • 1 866 tis. Kč
    • •
  • 1 866 tis. Kč
    • •
  • MŠMT
Project

Interactions of tumor suppressor proteins with DNA. Roles of DNA conformation and protein modifications (GA204/02/0734)

The ability of tumor suppressor protein p53 to bind to specific DNA sequences and recombination. Loss of the p53 DNA binding functions frequently results in cancer-related checkpoint proteins with...

CE - Biochemie

  • 2002 - 2004
    • •
  • 4 448 tis. Kč
    • •
  • 3 042 tis. Kč
    • •
  • GA ČR
Project

Binding of human and mouse tumour suppressor protein p53 to linear and supercoiled DNAs (GA301/00/D001)

Tumor suppressor functions ofp53 protein are maintained by its binding to DNA, preventing oncogenic transformation of normal cells. This project wants to extend our knowledge ofp53 protein binding to D...

CE - Biochemie

  • 2000 - 2003
    • •
  • 1 100 tis. Kč
    • •
  • 720 tis. Kč
    • •
  • GA ČR
Project

Local DNA structures and their role in mutant p53 protein function in human tumours (GA22-21903S)

binding and/or recognition of local DNA structures (cruciforms, triplexes cancers. Wild-type p53 binds DNA sequence-specifically, but also recognizes various non-B DNA structures. Most missense p53 mutant...

Oncology

  • 2022 - 2024
    • •
  • 7 056 tis. Kč
    • •
  • 7 056 tis. Kč
    • •
  • GA ČR
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

Interactions of tumor suppressor protein p53 with DNA are crucial for its-specific DNA binding, but also ability of both wt and mutant (mut) p53 to recognize DNA binding, and (3) influence of geno...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
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