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20 (0,083s) •

Project

The role of epicardial adipose tissue in heart disease novel mechanisms of action and its therapeutic modulation (NV15-26854A)

Adipose tissue and its dysfunction in obesity and type 2 diabetes play an important role in the development of cardiovascular complications. The aim of the project is to elucidate the role and the mechanism of action of epicardial adipose tissue in t...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2018
    • •
  • 14 359 tis. Kč
    • •
  • 14 359 tis. Kč
    • •
  • MZ
Project

Pheochromocytoma as a model of chronic activation of the stress axis in the pathogenesis of metabolic disorders (NV16-30345A)

Chronic stress is considered as a risk factor for developing insulin resistance and diabetes mellitus. Pheochromocytoma is a useful model for studying the influence of long-term catecholamines overproduction on cardiometabolic disorders in humans. Ca...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2016 - 2019
    • •
  • 12 909 tis. Kč
    • •
  • 12 909 tis. Kč
    • •
  • MZ
Project

The interplay of arterial wall and perivascular adipose tissue in the initiation of atherogenesis (NV17-28103A)

The relationship of the content and proportion of pro-inflammatory M1 and anti-inflammatory M2 macrophages between the human artery and adjacent perivascular adipose tissue will be determined (tissues obtained in kidney transplantation procedure from...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2017 - 2020
    • •
  • 4 229 tis. Kč
    • •
  • 4 229 tis. Kč
    • •
  • MZ
Project

Novel vascularized stem-cell based constructs for soft and hard tissue engineering (NU20-08-00208)

The project is focused on creating adipose and bone tissue replacements based on porous 3D nanofibrous polymeric scaffolds and adipose-derived stem cells (ASCs). The scaffolds will be prepared by centrifugal spinning of biodegradable polymers approve...

Biomaterials (as related to medical implants, devices, sensors)

  • 2020 - 2024
    • •
  • 12 403 tis. Kč
    • •
  • 12 266 tis. Kč
    • •
  • MZ
Project

Endocrine function of adipose tissue in the etiopathogenesis of the gestational diabetes. (NV15-27630A)

Gestational diabetes (GDM) is a disorder of glucose metabolism occurring in pregnancy which spontaneously disappears after delivery. Untreated GDM causes numerous pregnancy and perinatal complications for mothers and their offspring, they are at incr...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2018
    • •
  • 8 455 tis. Kč
    • •
  • 8 455 tis. Kč
    • •
  • MZ
Project

Macrophage polarization and the fatty acid spectrum of cell membrane phospholipids of adipose tissue (NU20-01-00022)

We have recently published that the proportion of pro-inflammatory macrophages of human adipose tissue (CD14+, CD16+, CD36+++) correlates positively with the main risk factors of atherosclerosis – age, BMI and non-HDL cholesterol concentration. In a ...

Endocrinology and metabolism (including diabetes, hormones)

  • 2020 - 2023
    • •
  • 4 242 tis. Kč
    • •
  • 4 242 tis. Kč
    • •
  • MZ
Project

The Role of De Novo Lipogenesis in Regulation of Insulin Sensitivity in adipose tissue in obese (NV19-01-00263)

Disturbances of de novo lipogenesis (DNL) are one of the features of dysfunction of adipose tissue (AT). Disturbances of DNL play a role in development of metabolic complications of obesity. The goal of this project is to investigate novel pathways o...

Endocrinology and metabolism (including diabetes, hormones)

  • 2019 - 2023
    • •
  • 13 162 tis. Kč
    • •
  • 12 629 tis. Kč
    • •
  • MZ
Project

Effect of EXercise training and Omega-3 fatty acids on metabolic health and DYsfunction of Adipose tissue in elderly (NV16-29182A)

Aging is associated with development of disturbances of lipid and carbohydrate metabolism and with systemic pro-inflammatory state. The studies performed with elderly people suggests that these characteristics may be improved by physical activity and...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2016 - 2019
    • •
  • 14 354 tis. Kč
    • •
  • 13 324 tis. Kč
    • •
  • MZ
Project

Impaired Free Fatty Acids Metabolism in Obstructive Sleep Apnea Syndrome (NV15-30155A)

Obstructive sleep apnea syndrome (OSA) is a disease affecting 5-15% of population and 50-80% of type 2 diabetes mellitus (T2DM) and obese subjects. OSA causally contributes to the development of glucose intolerance and T2DM. Our project is targeting ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2018
    • •
  • 16 128 tis. Kč
    • •
  • 16 077 tis. Kč
    • •
  • MZ
Project

Glucagon-like peptide 1 agonists and sodium-glucose cotransporter 2 inhibitors as a new pharmacological tool for the prevention of end-organ damage (NW25-01-00076)

According to the results of large clinical studies, some of the newer antidiabetic drugs can favorably influence the development and progression of renal dysfunctions, even regardless of the presence of diabetes. Renoprotective effects of sodium-gluc...

Endocrinology and metabolism (including diabetes, hormones)

  • 2025 - 2028
    • •
  • 11 213 tis. Kč
    • •
  • 11 213 tis. Kč
    • •
  • MZ
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