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20 (0,195s) •

Project

Role of rare variants in genetic predisposition to statin myopathy (NT14025)

The project objective is to determine the contribution of rare gene variants in SLCO1B1, SLCO1B3, and other known or unknown candidate genes to the mechanism of statin-induced myopathy. The presence of variants in approximately 70 patients w...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
    • •
  • 5 865 tis. Kč
    • •
  • 5 865 tis. Kč
    • •
  • MZ
Project

Myopathies in the elderly over 80 with hip fracture (NG6419)

80-90 in patients over 80 with hip fracture are to be invelved.Muscle bippsy in time of surgery is to be get and investigatedy on atrophy and myopathy icluding IBM. We will use electronmicroscopy as well as antibodies against beta amyloid,be...

FE - Ostatní obory vnitřního lékařství

  • 2000 - 2002
    • •
  • 647 tis. Kč
    • •
  • 647 tis. Kč
    • •
  • MZ
Project

Diagnostics and possibilities of prevention of atypical myopathy in the Czech Republic (QL24010403)

1. Monitoring the incidence of atypical myopathy (AM) in the Czech Republic (CR) in cooperation with field veterinarians (FV) and horse owners (HO). 2. Introduction of a routine method for toxin detection in seeds and seedlings of various m...

Veterinary science

  • 2024 - 2026
    • •
  • 5 097 tis. Kč
    • •
  • 4 332 tis. Kč
    • •
  • MZe
Project

Skeletal muscle metabolic abnormalities in patients with idiopathic inflammatory myopathies (NV16-33746A)

The idiopathic inflammatory myopathies (IIM) are systemic diseases affecting skeletal muscle, apparently as a consequence of inflammatory processes. In some patients, the muscle weakness remains even after pharmacological suppression in ...

FE - Ostatní obory vnitřního lékařství

  • 2016 - 2019
    • •
  • 9 387 tis. Kč
    • •
  • 9 387 tis. Kč
    • •
  • MZ
Project

Muscle metabolism after renal transplantation early exercise intervention, selective nutrition and gene polymorphism (NS10518)

Uremic myopathy is a major risk factor after renal transplantation. It impairs the mobility of patients and increases the incidence of early and long-term transplant-related complications including cardiomyopathy. Its prevalence is about 50%...

FJ - Chirurgie včetně transplantologie

  • 2009 - 2011
    • •
  • 3 725 tis. Kč
    • •
  • 3 725 tis. Kč
    • •
  • MZ
Project

Critical illness polyneuromyopathy (NF5980)

Prospective 2-year clinical and electrophysiological follow-up study wil be performed in intensive care unit patients to analyse possible etiological factors contributing to the development of acquired muscle weakness.......

FH - Neurologie, neurochirurgie, neurovědy

  • 2000 - 2002
    • •
  • 1 879 tis. Kč
    • •
  • 1 871 tis. Kč
    • •
  • MZ
Project

Immunohistochemical detection of nestin as a diagnostic marker in pathomorphology (NK6727)

Project is focused on the study of nestin expression during development of normal tissues and in tissues affected by certain types of disorders. Aim of the study is to judge a diagnostic and prognostic significance of imunohistochemical detection of ...

EA - Morfologické obory a cytologie

  • 2001 - 2003
    • •
  • 2 313 tis. Kč
    • •
  • 1 944 tis. Kč
    • •
  • MZ
Project

Clinical and prognostic significance of BAFF (B-cell activating factor) and its receptors in idiopatic inflammatory myopathies (NT12438)

a) Quantitative analysis of serum levels of BAFF (B cell activating factor of the TNF family) and expression of its receptors (BAFF-R, TACI and BCMA) on immunologically relevant cells in peripheral blood and muscle infiltrate to pathogenetic mechanis...

FE - Ostatní obory vnitřního lékařství

  • 2011 - 2014
    • •
  • 5 276 tis. Kč
    • •
  • 5 276 tis. Kč
    • •
  • MZ
Project

Myokines and metabolically active molecules in the pathogenesis of idiopathic inflammatory myopathies (NU21-05-00322)

Patients with idiopathic inflammatory myopathies (IIM) suffer from muscle weakness and muscle wasting, a condition in which increased pro-atrophic and decreased anabolic factors, such as myokines myostatin and follistatin, would be expected....

Rheumatology

  • 2021 - 2025
    • •
  • 10 887 tis. Kč
    • •
  • 10 887 tis. Kč
    • •
  • MZ
Project

Early detection of neurological complications of HIV-1 infection (NI5673)

Prospective study for early detection of HIV-1 associated neurological diseases is proposed. Non-invasive neuropsychological and electrophysiological screening battery is designed for detection of initial symptoms. When indicated, HAART therapy will ...

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
    • •
  • 855 tis. Kč
    • •
  • 855 tis. Kč
    • •
  • MZ
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