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Preparation of protracted-action peptide regulators of insect reproduction based on morphological changes and structure/activity relationships (GA203/98/0741)
Reproduction control of insect pests can significantly contribute to reducing the costs of world food production. The basic objective of the project is optimization of the structure of peptides which affect insect oogenesis and thereby contr...
CC - Organická chemie
- 1998 - 2000 •
- 2 248 tis. Kč •
- 984 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1998 - 1. 1. 2000
Uznané náklady
Podpora ze státního rozpočtu (44%)
Poskytovatel: Grantová agentura České republiky
Cellular and molecular basis of oogenesis fertilization and embryonic development in mammals (GV524/96/K162)
Results derived from the experiments involved in the proposed grant will potentially shed light not only on biochemical regulation of growth and maturation of mammalian oocytes, but it will allow to develop novel protocols which allow to include grow...
EB - Genetika a molekulární biologie
- 1996 - 2001 •
- 33 038 tis. Kč •
- 25 187 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1996 - 1. 1. 2001
Uznané náklady
Podpora ze státního rozpočtu (76%)
Poskytovatel: Grantová agentura České republiky
Effect of DNA copy number variation on fertility of the house mouse (GA16-19158S)
The PRDM9 protein is an epigenetic factor necessary for both male and female fertility in the laboratory mouse that determines the sites of meiotic recombination. PRDM9 variants contribute to non-allelic homologous recombination leading to genomic di...
EB - Genetika a molekulární biologie
- 2016 - 2020 •
- 4 979 tis. Kč •
- 4 733 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2016 - 11. 12. 2020
Uznané náklady
Podpora ze státního rozpočtu (95%)
Poskytovatel: Grantová agentura České republiky
The role of the nucleolus precursor body in oogenesis and early embryonic development (GPP302/11/P069)
In somatic cells, the nucleolus is composed from three basic components and is primarily the site of ribosome biogenesis. In fully-grown mammalian oocytes a corresponding structure cannot be observed as these cells contain a so called nucleolus pre...
EA - Morfologické obory a cytologie
- 2011 - 2013 •
- 3 729 tis. Kč •
- 3 729 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2011 - 31. 12. 2013
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Control of hotspots of meiotic double-strand DNA breaks in Rattus norvegicus (GA16-06548S)
The sites of meiotic double strand breaks and thus the sites of genetic recombination are determined by the PRDM9 (PR/SET-domain carrying 9) protein, an epigenetic factor that carries histone-3-lysine-4 (H3K4) methyltransferase activity. This protein...
EB - Genetika a molekulární biologie
- 2016 - 2020 •
- 8 727 tis. Kč •
- 8 274 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2016 - 11. 12. 2020
Uznané náklady
Podpora ze státního rozpočtu (95%)
Poskytovatel: Grantová agentura České republiky
Ultrastructural markers of human oocyte quality (GJ19-14990Y)
Egg quality is crucial for proper embryo development. In humans, poor developmental competence of oocytes is a major obstacle to conception and a cause of female infertility. In the absence of detailed knowledge of subcellular morphology, criteria of...
Cell biology
- 2019 - 2023 •
- 4 204 tis. Kč •
- 4 204 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2019 - 31. 12. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Maternal protein degradation and its impact on the development quality of mammalian preimplantation embryo (GA23-05108S)
The early embryonic development is initially driven by maternally inherited mRNAs and proteins synthesized during oogenesis. These reserves are used until embryonic genome activation (EGA) when transcription from embryonic genome starts. Mat...
Developmental biology
- 2023 - 2025 •
- 8 123 tis. Kč •
- 8 123 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2023 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Neuroendocrine control of insect reproductive diapause and metamorphosis (GA15-23681S)
Insects are the most prolific group of animals on earth, and many cause concern as pests and disease vectors. Insect success relies on two hormonally regulated life strategies: development through metamorphosis and the capacity to postpone developmen...
ED - Fyziologie
- 2015 - 2019 •
- 8 627 tis. Kč •
- 8 627 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2015 - 29. 11. 2019
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The genetic basis of species origin What can we learn from organisms with female heterogamety? (GA18-14325S)
A large effect of sex chromosomes in speciation belongs to the most general patterns in evolutionary biology. The underlying mechanisms are, however, still poorly understood and the vast majority of studies exploring the role of sex chromosomes in sp...
Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
- 2018 - 2022 •
- 9 774 tis. Kč •
- 9 774 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2018 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Characterisation of Hippo-signalling related genes during mouse oocyte maturation, acentrosomal cell division & blastocyst cell lineage allocation. (GA21-03305S)
Mammalian oogenesis and preimplantation embryogenesis are important research areas relevant to human/animal reproductive health (e.g. IVF) and excellent self-contained models for cell biological studies (e.g. cell division, differentiation, ...
Cell biology
- 2021 - 2024 •
- 8 147 tis. Kč •
- 8 147 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2021 - 30. 6. 2024
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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