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62 (0,102s) •

Project

Wnt ligands and Wnt-secreting cells for intestinal homeostasis, regeneration and colon cancer a complex world beyond the cancer-activating mutation (GA18-21466S)

Targeting Wnt signaling represents a promising therapy against colon cancer. Although the role of Wnt-activating mutation for initiation and progression of colon cancer is clearly described, the activity of complex world of Wnt<...

Developmental biology

  • 2018 - 2022
    • •
  • 8 406 tis. Kč
    • •
  • 7 632 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of non-canonical Wnt signaling in leukemia (GAP301/11/0747)

Wnts, a family of glycoproteins, signal through a variety of signaling pathways of non-canonical Wnt signalling (Wnt/PCP pathway) in context of B-Cell Chronic LymphocyticLeukaemia (CLL). Functional studies of the Wnt

FD - Onkologie a hematologie

  • 2011 - 2014
    • •
  • 5 360 tis. Kč
    • •
  • 5 360 tis. Kč
    • •
  • GA ČR
Project

Posttranslational modification of Dishevelled (KJB501630801)

Wnts are secreted factors and regulators of embryonic development, disease and regeneration. Mutations in the Wnt pathway are crucial in pathogenesis of many diseases, including cancer. Wnts bind Frizzled family of receptor...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 290 tis. Kč
    • •
  • 1 290 tis. Kč
    • •
  • AV ČR
Project

The role of beta-arrestin in achieving Wnt-signaling specificity (GC204/09/J030)

-canonical Wnt-pathways. A number of new variations of Wnt-signaling, especially of the individual branches of Wnt signaling. To test this hypothesis, we will characterize the molecular function and interacting proteins of ...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 3 888 tis. Kč
    • •
  • 3 888 tis. Kč
    • •
  • GA ČR
Project

The role of Wnt/beta-catenin signaling during neurogenesis. (GA17-05466S)

Wnt signaling plays an essential role in the development of mammalian CNS. We will investigate the impact of the canonical Wnt pathway both on neuronal/glial differentiation will be stimulated with conditional media from neonatal ne...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2021
    • •
  • 5 720 tis. Kč
    • •
  • 5 556 tis. Kč
    • •
  • GA ČR
Project

Molecular cloning and functional characterization of the Wnt signaling pathway components in man (IAA5052905)

Wnt proteins are secreted signaling molecules that regulate diverse developmental processes. The Wnt action is mediated via a signal transducing cascade of the opithelial cells, hasbeen observed in human colon carcinomas upon the ab...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 2 936 tis. Kč
    • •
  • 1 676 tis. Kč
    • •
  • AV ČR
Project

The role of phosphoinositides in Wnt signalling (GJ16-17966Y)

The Wnt signalling pathway is essential for many events during human the importance of PIP metabolism in Wnt pathway control. To elaborate on these findings, we in the regulation of Wnt signalling cascade. First, we will in...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 6 795 tis. Kč
    • •
  • 6 795 tis. Kč
    • •
  • GA ČR
Project

Tumor suppressors in the Wnt signaling pathway (GA204/07/1567)

Wnt signaling controls embryonic development and the aberrant activation of the Wnt pathway leads to cancer. In canonical signaling beta-catenin acts with the TCF of the Wnt pathway. HIC1 encodes a zinc-finger transcription...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 433 tis. Kč
    • •
  • 4 433 tis. Kč
    • •
  • GA ČR
Project

Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling (GA204/09/0498)

Mutations in the Wnt signalling pathway cause several human diseases including (Dvl) ? a key component of the Wnt signalling pathway. We plan to describe with respect (i) to the Wnt pathway activation, (ii) to Dvl phoshoryl...

CE - Biochemie

  • 2009 - 2013
    • •
  • 6 895 tis. Kč
    • •
  • 6 895 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms regulating development and malignant transformation of intestinal tissues (GA312/99/0348)

The Wnt genes encode a family of secreted glycoproteins that control diverse organisms. It is well established that the aberrant activation of the Wnt pathway contributes to intestinal cancer. The opposite phenomenon, the disruption...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 1 762 tis. Kč
    • •
  • 1 602 tis. Kč
    • •
  • GA ČR
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