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1 424 (0,095s) •

Project

Imaging of mitochondrial substructure by 3D high resolution microscopy (ME09029)

-CFP2-ATAD3 and Eos-TFAM. Membrane countours will be attempted by FP-conjugated membrane marker proteins. Mitochondrial nucleoid distribution will be studied imaging of mitochondrial network morphology in cells and...

EA - Morfologické obory a cytologie

  • 2009 - 2012
    • •
  • 2 376 tis. Kč
    • •
  • 2 376 tis. Kč
    • •
  • MŠMT
Project

Role of mitochondria in developmental changes of cardiac tolerance to oxygen deprivation (GA305/00/1659)

of cardiac mitochondria by measuring mitochondrial membrane potential; (ii) to analyze possible links between ontogenetic changes in mitochondrial uncoupling protein (UCP2 that age-dependent changes in mitochondrial

ED - Fyziologie

  • 2000 - 2002
    • •
  • 6 336 tis. Kč
    • •
  • 3 196 tis. Kč
    • •
  • GA ČR
Project

Structure and Function of Mitochodrial Secretins (LH15253)

of the protein insertion into mitochondrial membranes, b) to characterize to properties of the formed membrane pore, c) to identify secretin-interacting proteins and d) to describeIt is the aim of the project to biochemica...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 1 991 tis. Kč
    • •
  • 1 991 tis. Kč
    • •
  • MŠMT
Project

Mechanism of ROS generation and mitochondrial permeabilization (GA204/08/0811)

the molecular mechanism of ROS generation and mitochondrial destabilisation. Preliminary of dimerisation viadisulfide bridges and mitochondrial translocation of Bax, or by transcriptional upregulation of Noxa that removes Mcl-1 fro...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 4 386 tis. Kč
    • •
  • 4 386 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial membrane contact sites with the nuclear envelope and nucleoids analysed by FIB/SEM and fluorescence nanoscopy (GA22-02203S)

these newly established techniques to visualize mitochondrial nucleoids, their contacts with inner mitochondrial membranes, and localization in MERCs. The project aimsMembrane contact sites (MCSs) represent key hu...

Anatomy and morphology (plant science to be 1.6)

  • 2022 - 2025
    • •
  • 7 871 tis. Kč
    • •
  • 7 823 tis. Kč
    • •
  • GA ČR
Project

Apoptosis-inducing factor (AIF) its translocation from mitochondria and its action on nuclear chromatin (GP204/03/D031)

of the cell death. During the permeabilization of mitochondrial membrane in apoptosis, the outer mitochondrial membrane becomes soluble to proteins including cytochrome c from mitochondria and connection of this m...

EB - Genetika a molekulární biologie

  • 2003 - 2006
    • •
  • 738 tis. Kč
    • •
  • 738 tis. Kč
    • •
  • GA ČR
Project

Evolutionary adaptation of the inner membrane protein translocase to the loss of membrane potential in anaerobic mitochondria-like organelles (LUABA22082)

1. Bioinformatic and in silico structural comparison of the core TIM23 subunits from mitochondria and MROs that lack the membrane potential 2. Bioinformatic and functional comparisons of targeting presequences of mitochondrial and ...

Cell biology

  • 2022 - 2024
    • •
  • 1 200 tis. Kč
    • •
  • 1 200 tis. Kč
    • •
  • MŠMT
Project

Transformation of the endosymbiont into the organelle. (GA13-29423S)

The transformation of the alphaproteobacterial endosymbiont into mitochondrion was accompanied by dramatic changes in the biogenesis of this new double membrane-bounded compartment. (i) the protein flow across the membranes reversed...

EB - Genetika a molekulární biologie

  • 2013 - 2018
    • •
  • 7 798 tis. Kč
    • •
  • 7 798 tis. Kč
    • •
  • GA ČR
Project

Structure-function characterization of human i-AAA protease, Yme1l1, and translocase Oxa1l in the biogenesis of the oxidative phosphorylation system (GPP305/10/P414)

Yme1l1 is the human homologue of the yeast mitochondrial i-AAA metalloprotease on the intermembrane side of the inner membrane. Oxa1l is the human homologue of the yeast mitochondrial Oxa1 translocase. It is an integral pro...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 2 887 tis. Kč
    • •
  • 2 887 tis. Kč
    • •
  • GA ČR
Project

Mitoribosome in Trypanosoma brucei biogenesis and unique traits of a divergent protein synthesis machine (GJ20-04150Y)

mitochondrial membrane, how the highly hydrophobic translation products are co-translationally inserted into the membrane, and why the polypeptide exit tunnel branches to multiple peculiarities of kinetoplastid mitocho...

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 6 855 tis. Kč
    • •
  • 6 855 tis. Kč
    • •
  • GA ČR
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