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1 292 (0,12s) •

Project

The role of the ubiquitin and ubiquitin-like proteins in life cycle of the Mason-Pfizer monkey virus (GP301/06/P278)

for the forming of infective retroviral particles have been proved. Tha major aim of retroviral particle of Mason-Pfizer Monkey Virus (M-PMV). The goal is to find and transport of retroviral RNA, course o...

EE - Mikrobiologie, virologie

  • 2006 - 2008
    • •
  • 1 167 tis. Kč
    • •
  • 1 167 tis. Kč
    • •
  • GA ČR
Project

The analysis of molecular organization of the retrovirus particle and interactions leading to its assembly (ME 904)

of formation of retroviral particles. This will be made possible by the employment in the collaboratinglaboratories. The in vitro assembly method of virus like particles and study formation, the laboratory of prof. McPhers...

EE - Mikrobiologie, virologie

  • 2007 - 2011
    • •
  • 2 391 tis. Kč
    • •
  • 2 391 tis. Kč
    • •
  • MŠMT
Project

Dimerisation of retroviral proteinases characterisation, structure-activity and inhibition study (GA303/98/1559)

of mature, infectious particles. Retroviral PRs are thus an attractive target for antiviral chemotherapy. All retroviral PRs are active as dimers. The dimerisation of retroviral PRs is a crucial step for the regul...

CE - Biochemie

  • 1998 - 2000
    • •
  • 2 878 tis. Kč
    • •
  • 2 643 tis. Kč
    • •
  • GA ČR
Project

Modulation of capsid protein hexameric lattice stability a promising target for HIV-1 inhibition (GA20-19906S)

The immature and mature lattices of retroviral particles are both formed of capsid protein (CA) hexamers, however their inter-hexamer and intra-hexamer contacts differ. Any modulation of both immature and mature CA lattices stabilit...

Virology

  • 2020 - 2022
    • •
  • 6 940 tis. Kč
    • •
  • 6 604 tis. Kč
    • •
  • GA ČR
Project

Role of retroviral matrix protein in virus particle targeting and interaction with plasma membrane. (GAP302/12/1895)

by studying the interactions of retroviral structural proteins or whole viral particles with the cytoplasmic membrane. We aim to study the retroviral matrix protein (MA), a key virus-like particles. We will also s...

EE - Mikrobiologie, virologie

  • 2012 - 2016
    • •
  • 8 835 tis. Kč
    • •
  • 8 835 tis. Kč
    • •
  • GA ČR
Project

Study of structure and interactions critical for formation of immature retroviral particles for testing and rational design of HIV assembly inhibitors (GA14-15326S)

Assembly of immature retroviral particle is driven by oligomerization that rearrange into mature, infectious particle. Immature particle formation is mediated originates from the 8Å structure of immature partic...

EE - Mikrobiologie, virologie

  • 2014 - 2016
    • •
  • 6 285 tis. Kč
    • •
  • 6 285 tis. Kč
    • •
  • GA ČR
Project

Structural study of protein domains of monkey retrovirus (IAA4055304)

Temporal and spatial separation of assembly of immature capsid particles from their release makes Mason-Pfizer monkey virus (M-PMV), inducing an AIDS like syndrom in non-human primates, an attractive experimental model for the study of r...

CE - Biochemie

  • 2003 - 2007
    • •
  • 11 354 tis. Kč
    • •
  • 4 282 tis. Kč
    • •
  • AV ČR
Project

Structure, function, substrate specificity and inhibition of retroviral proteinases protein engineering study of retroviral processing (IA455102)

CE - Biochemie

  • 1993 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • AV ČR
Project

The construction of retroviral particles with their potential use as a therapeutic delivery systems (KJB501270701)

), is able to form spherical particles in vitro with the ability to incorporate nucleic. The N-terminal extension of ((pro-)CANC) does not interphere with particle formation transport (at the N-terminus of fusion protein) on par...

EE - Mikrobiologie, virologie

  • 2007 - 2009
    • •
  • 1 209 tis. Kč
    • •
  • 1 209 tis. Kč
    • •
  • AV ČR
Project

Transcriptional silencing of retroviral vectors during their integration into the host genome (GP301/09/P667)

The transcriptional silencing of retroviral vectors represents major of silencing differs among retroviral vectors of different origin. ASLV-based vectors in gene therapy. Silencing of retroviral vectors is observed in two ...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 1 292