All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

11 (0,064s) •

Project

Subspecies-specific function of meiotic genes in mouse gametogenesis (GA14-20728S)

The Prdm9 gene, encoding meiosis-specific histone methyltransferase, has been extensively studied in the last 5 years. In the man, cow, and mouse, PRDM9 determines the hot-spots of meiotic recombination. In 2009, we identified P...

EB - Genetika a molekulární biologie

  • 2014 - 2018
    • •
  • 4 346 tis. Kč
    • •
  • 4 346 tis. Kč
    • •
  • GA ČR
Project

The role of Prdm9 allelic variations and activity in hybrid sterility in mice. (GA17-04364S)

strains representing two mouse subspecies showed that the heterozygosity of Prdm9 gene and meiotic chromosome synapsis failure. Prdm9 is defining the hotspot placement will study the role of different Prdm9 alleles in F1 m...

EB - Genetika a molekulární biologie

  • 2017 - 2020
    • •
  • 8 315 tis. Kč
    • •
  • 7 352 tis. Kč
    • •
  • GA ČR
Project

The role of PRDM9-mediated synapsis of meiotic chromosomes in hybrid sterility (GA20-04075S)

By using laboratory strains of mice as a model we identified Prdm9 as the first of Prdm9 in meiotic recombination, chromosome pairing, and fertility of hybrids between wild mice with sequenced ZnF domains of Prdm9 and genet...

Genetics and heredity (medical genetics to be 3)

  • 2020 - 2022
    • •
  • 10 811 tis. Kč
    • •
  • 10 568 tis. Kč
    • •
  • GA ČR
Project

Sperm quality control by the meiotic histone methyltransferase PRDM9 (GA19-06272S)

PRDM9 is a histone methyltransferase that determines the sites of double (Mus m. domesticus) lacking PRDM9 displays relocation of recombination initiation accomplish meiosis also using PRDM9-independent recombination sites....

Genetics and heredity (medical genetics to be 3)

  • 2019 - 2022
    • •
  • 8 384 tis. Kč
    • •
  • 8 075 tis. Kč
    • •
  • GA ČR
Project

Effect of DNA copy number variation on fertility of the house mouse (GA16-19158S)

The PRDM9 protein is an epigenetic factor necessary for both male and female. PRDM9 variants contribute to non-allelic homologous recombination leading to genomic disorders and were found in sterile men. We identified Prdm9...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 4 979 tis. Kč
    • •
  • 4 733 tis. Kč
    • •
  • GA ČR
Project

Control of hotspots of meiotic double-strand DNA breaks in Rattus norvegicus (GA16-06548S)

recombination are determined by the PRDM9 (PR/SET-domain carrying 9) protein, an epigenetic yet not all mice heterozygous for certain Prdm9 mutations display sex-specific in Prdm9 mutations or in genetic background. Steril...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 8 727 tis. Kč
    • •
  • 8 274 tis. Kč
    • •
  • GA ČR
Project

Epigenetic regulators of gene expression in mouse spermatogenesis (GPP305/11/P630)

In our laboratory, have identified hybrid sterility gene Prdm9, which is crucial for the epigenetic regulation of expression during mouse spermatogenesis. In a search for genes, which have a similar mRNA expression pattern as Prdm9,...

EB - Genetika a molekulární biologie

  • 2011 - 2013
    • •
  • 2 957 tis. Kč
    • •
  • 2 957 tis. Kč
    • •
  • GA ČR
Project

Evolution of hybrid male sterility in the European house mouse (GA19-12774S)

Two house mouse subspecies, Mus m. musculus and M. m. domesticus, that diverged between 0.5 MYR, undergo recipient speciation. Laboratory based crosses between the subspecies readily document the presence of F1 sterile males. This sterility is contro...

Zoology

  • 2019 - 2022
    • •
  • 9 811 tis. Kč
    • •
  • 9 694 tis. Kč
    • •
  • GA ČR
Project

Reconstituting a minimum hybrid sterility genome (GA22-29928S)

In this project we want to finalize our contribution to the basic question of life on Earth, first asked by Darwin, which concerns speciation - the origin of new species. Our team identified the first hybrid sterility gene in vertebrates, Prdm9

Genetics and heredity (medical genetics to be 3)

  • 2022 - 2023
    • •
  • 6 638 tis. Kč
    • •
  • 6 494 tis. Kč
    • •
  • GA ČR
Project

Identification of interactors of the meiotic histone methyltransferase Hybrid sterility 1 (PR-domain 9) (GAP305/10/1931)

The proposal of this project is based on our recent discovery of a gene participating in a multigenic type of hybrid sterility. The Hybrid sterility 1 (Hst1) gene was isolated by positional cloning and it is a first vertebrate candidate for a speciat...

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 6 107 tis. Kč
    • •
  • 6 107 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 11