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318 (0,125s) •

Project

Regulation of adaptive immune response by intestinal epithelial cells (LL2315)

. The main objective of the project is to decipher the mechanisms used by the intestinal epithelium to influence the adaptive immune response and to reciprocally investigate the impact of adaptive immunity on the intestinal...

Immunology

  • 2023 - 2025
    • •
  • 17 578 tis. Kč
    • •
  • 17 578 tis. Kč
    • •
  • MŠMT
Project

Pushing the limits of the cellular plasticity in the intestinal epithelium by altering the cellular fates of differentiated cells (GA25-17207S)

molecular mechanisms driving the cellular plasticity of the intestinal epithelium duringThe cellular plasticity connected to re-activated embryonic gene expression allows the intestinal epithelial cells to face epithelial ...

Cell biology

  • 2025 - 2027
    • •
  • 11 806 tis. Kč
    • •
  • 11 806 tis. Kč
    • •
  • GA ČR
Project

Characterization of early stages of intestinal tumorigenesis induced by non-physiological activation of Wnt signaling (GA20-31322S)

in intestinal epithelium self-renewal, we believe that the project will bring new insights dedicated to elucidation of early steps of intestinal tumorigenesis caused by the loss lesions formed in the small intestinal

Cell biology

  • 2020 - 2022
    • •
  • 8 985 tis. Kč
    • •
  • 8 985 tis. Kč
    • •
  • GA ČR
Project

Importance of Toll-like receptors in intestinal epithelium response to cyanobacterial water bloom (GA16-24949S)

activation of TLRs in intestinal epithelial cells can be responsible for induction with specific TLR and can trigger inflammatory reaction in intestinal epithelial cells. Activation of particular TLR will be screened and characteri...

DN - Vliv životního prostředí na zdraví

  • 2016 - 2020
    • •
  • 6 733 tis. Kč
    • •
  • 6 475 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms underlying cell-fate decisions in the intestine (GA14-33952S)

Gastrointestinal epithelia represent the most rapidly self-renewing tissue in the adult mammalian body. The homeostasis of the single-layer epithelium depends development of CBC stem cells in the small intestine. The principal objec...

EB - Genetika a molekulární biologie

  • 2014 - 2018
    • •
  • 7 470 tis. Kč
    • •
  • 7 470 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms regulating development and malignant transformation of intestinal tissues (GA312/99/0348)

contributes to intestinal cancer. The opposite phenomenon, the disruption of Wnt signaling in the intestine, was observed upon inactivation of the mouse Tcf-4 gene. Tcf-4 encodes a member of the Wnt pathway specifically expressed i...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 1 762 tis. Kč
    • •
  • 1 602 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of gut function modulation by nutritional hyaluronan (GA25-16326S)

the efficacy of nutritionally supplied HA in the treatment of chronic intestinal and unsaturated HA oligosaccharides on chronic intestinal inflammation using an established in the inflamed intestine after p.o. HA applicati...

Biochemistry and molecular biology

  • 2025 - 2028
    • •
  • 8 019 tis. Kč
    • •
  • 8 019 tis. Kč
    • •
  • GA ČR
Project

Molecular cloning and functional characterization of the Wnt signaling pathway components in man (IAA5052905)

, transcription factor Tcf-4, results in a severe proliferative defect in the small intestine. The Tcf-4 deficient intestinal epithelium lacks crypts and contains only mature non activation. These data imply a regulatory ro...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 2 936 tis. Kč
    • •
  • 1 676 tis. Kč
    • •
  • AV ČR
Project

The canonical Wnt pathway components involved in non-canonical signaling mechanisms (GA18-26324S)

will be employed to identify the composition of LGR4 protein complexes in mouse intestinal in the adult colon, colon cancer, and intestinal regeneration will be characterized using transgenic mouse models, intestinal organ...

Cell biology

  • 2018 - 2022
    • •
  • 9 615 tis. Kč
    • •
  • 8 721 tis. Kč
    • •
  • GA ČR
Project

Wnt signaling in self-renewal and tumorigenesis of the intestinal epithelia (GAP305/11/1780)

of intestinal cancer. The first part of the project is focused on the Wnt signaling target in intestinal neoplasia. We will elucidate, using mouse strains prone to intestinal cancer intestine. Distinct sets of gen...

EB - Genetika a molekulární biologie

  • 2011 - 2014
    • •
  • 8 400 tis. Kč
    • •
  • 8 400 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 318