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59 (0,146s) •

Project

Emergency granulopoiesis at the level of hematopoietic stem and progenitor cells The role of population dynamics and Wnt/β-catenin signaling (GA22-18300S)

and activation of the β-catenin signaling pathway in HSC/MPP. Using single cell the role Wnt10b/β-catenin in EG onset. The results from this project will challenge our......

Immunology

  • 2022 - 2024
    • •
  • 8 676 tis. Kč
    • •
  • 8 544 tis. Kč
    • •
  • GA ČR
Project

Mechanisms regulating normal and leukemic hematopoietic stem cells Deciphering the role of the beta-catenin/Tcf signaling pathway (GA17-02177S)

is abundantly expressed in HSC and that by forming a complex with β-catenin it might, and whether targeting the formation of the β-catenin/Tcf4 complex could serve......

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 6 927 tis. Kč
    • •
  • 6 213 tis. Kč
    • •
  • GA ČR
Project

Reconstruction of an ancestral chordate organizer the role of Wnt/beta-catenin signaling. (GC15-21285J)

is to investigate the function of Wnt/β-catenin signaling in dorsal axis formation and organizer...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 5 940 tis. Kč
    • •
  • 5 124 tis. Kč
    • •
  • GA ČR
Project

Role of PI-3 iinase and Akt in regulation of the beta-catenin function in the colorectal adenocarcinoma cells (KJB5052302)

catenin-mediated signal transduction. Interaction of E-cadherin and/or beta-catenin will be paid to a translocationof beta-catenin into the cell nucleus in the IEC-6 cells and differentiation status as well as the beta-

EB - Genetika a molekulární biologie

  • 2003 - 2004
    • •
  • 1 443 tis. Kč
    • •
  • 851 tis. Kč
    • •
  • AV ČR
Project

Molecular basis of canonical Wnt signalling during eye and brain development (GA204/08/1618)

Beta-catenin protein posseses dual function as it is required for cell adhesion. Using the ongoing support from GACR we have investigated beta-catenin gain. In the follow-up project we would like to focus on the transcriptional role...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 3 555 tis. Kč
    • •
  • 3 555 tis. Kč
    • •
  • GA ČR
Project

Uncovering the Wnt Destruction complex effects on NOTCH receptor signaling in vertebrates (GA24-10622S)

the signaling with the NOTCH1 and Wnt/β-catenin signaling is mediated by the components...

Developmental biology

  • 2024 - 2026
    • •
  • 6 999 tis. Kč
    • •
  • 6 999 tis. Kč
    • •
  • GA ČR
Project

Poly-β-malic acid and its role as a possible primitive predecessor of nucleic acids (LTAUSA18085)

The aim of the project will be to confirm the existence of a double strand hydrogen bonded form of poly-β-L-malic acid, to examine the ability to generate a simple genetic alphabet with synthetically prepared β-linked oligomers form...

Biophysics

  • 2019 - 2022
    • •
  • 3 111 tis. Kč
    • •
  • 3 111 tis. Kč
    • •
  • MŠMT
Project

Principal signaling pathways regulating NG2 glia proliferation and differentiation following brain injuries (GA17-04034S)

-mediated Wnt/β-catenin pathway activation (or inhibition) or blocking the Shh pathway...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2019
    • •
  • 12 507 tis. Kč
    • •
  • 11 937 tis. Kč
    • •
  • GA ČR
Project

Involvement of Wnt/β-catenin signaling in neurogenesis and gliogenesis following brain ischemic injury - analysis at the single cell level (GA21-24674S)

Ischemic injury of the brain is a pathological situation leading to death or permanent impairment of the cognitive, sensory, and motor functions. Recent studies indicate that the Wnt signaling pathway promotes cell proliferation and neurogenesis in t...

Neurosciences (including psychophysiology)

  • 2021 - 2023
    • •
  • 12 173 tis. Kč
    • •
  • 12 173 tis. Kč
    • •
  • GA ČR
Project

Tumor suppressors in the Wnt signaling pathway (GA204/07/1567)

Wnt signaling controls embryonic development and the aberrant activation of the Wnt pathway leads to cancer. In canonical signaling beta-catenin acts with the TCF/LEF factors to transduce the signal from the membrane to the nucleus. Recently...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 433 tis. Kč
    • •
  • 4 433 tis. Kč
    • •
  • GA ČR
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