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Projects

5 302 projects (0,185s) •

Project

Complexes of IL-2 and anti-IL-2 mAb with selective stimulatory activity for CD25+ T cells in cancer immunotherapy changing the paradigm (GA22-20548S)

Complexes of IL-2 and anti-IL-2 mAbs possess extremely high biological activity in vivo. Moreover, such IL-2 complexes have selective stimulatory activity for different IL-2 responsive cells depending on the clone ...

Oncology

  • 2022 - 2024
    • •
  • 8 330 tis. Kč
    • •
  • 8 330 tis. Kč
    • •
  • GA ČR
Project

IL-2 complexed with muteins of JES6-1 mAb having different affinity to IL-2 finding variant with most selective stimulation of Treg cells in vivo (GA18-12973S)

Complexes of IL-2 and anti-IL-2 mAb JES6-1 potently expand CD25+ cells, i.e to understanding the mechanism how these complexes interact with high affinity trimeric IL-2 receptor. JES6-1 mAb sterically blocks the interaction...

Immunology

  • 2018 - 2022
    • •
  • 4 804 tis. Kč
    • •
  • 4 762 tis. Kč
    • •
  • GA ČR
Project

Strong sustained IL-2 signal selectively targeted to CD25+ cells dramatically increases sensitivity to LPS-mediated mortality finding the mechanism (GA13-12885S)

It has been shown previously that complexing IL-2 with certain anti-IL-2 mAb enourmously increases activity of IL-2 in vivo. These immunocomplexes selectively stimulate different subsets of immune cells depending on clone ...

EC - Imunologie

  • 2013 - 2018
    • •
  • 11 872 tis. Kč
    • •
  • 11 872 tis. Kč
    • •
  • GA ČR
Project

*Modernization of the VS 2 ejection seat. (FT-TA3/046)

*Modernization of the VS 2 ejection seat....

JU - Aeronautika, aerodynamika, letadla

  • 2006 - 2008
    • •
  • 35 869 tis. Kč
    • •
  • 18 212 tis. Kč
    • •
  • MPO
Project

Study of anion processes relevant for astrophysics (7AMB14AT023)

The primary objective of the project on the czech side is the measurement of the temperature dependence of the rate coefficients of O - + H 2 -> H 2 O + e - O - + H 2 of the isotopicexchange H 2 /D 2 . The...

CF - Fyzikální chemie a teoretická chemie

  • 2014 - 2015
    • •
  • 200 tis. Kč
    • •
  • 200 tis. Kč
    • •
  • MŠMT
Project

Aspects of immune response and efficacy of booster dose of SARS-CoV-2 mRNA vaccine in kidney transplant recipients (NU22-C-126)

1) Evaluate safety and imunogenicity of booster dose of SARS-CoV-2 mRNA vaccine in kidney transplant recipients. 2) Evaluate association between booster dose of SARS-CoV-2 mRNA vaccine and risk of SARS-CoV-2 infect...

Transplantation

  • 2022 - 2023
    • •
  • 6 194 tis. Kč
    • •
  • 6 194 tis. Kč
    • •
  • MZ
Project

Arrangement of the participation in the OECD MCCI - 2 project and using of its results (LA 295)

participation in OECD MCCI - 2 project, investigation of mechanisms of heat divertion at interaction melt - concrete...

JF - Jaderná energetika

  • 2006 - 2009
    • •
  • 4 210 tis. Kč
    • •
  • 1 790 tis. Kč
    • •
  • MŠMT
Project

Synthesis of nonracemic helical aromatics employing transition metal catalysis (GA203/07/1664)

: (a) diastereoselective [2+2+2] cyclotrimerisation of aromatic triynes containing two asymmetric) diastereoselective [2+2+2] cyclotrimerisation of chiral complexes of pyridine triynes with chiral...

CC - Organická chemie

  • 2007 - 2009
    • •
  • 3 059 tis. Kč
    • •
  • 3 059 tis. Kč
    • •
  • GA ČR
Project

Novel clinically relevant IL-2 immunotherapeutics for cancer treatment (GA20-13029S)

Mouse IL-2/S4B6 mAb complexes with potent stimulatory activity for memory CD8 IL-2. Potential clinical use of these complexes is limited due to the mouse origin of IL-2 and dissociation of the complexes at low concentration...

Immunology

  • 2020 - 2022
    • •
  • 12 596 tis. Kč
    • •
  • 12 596 tis. Kč
    • •
  • GA ČR
Project

Phosphorylation dependent regulation of human ubiquitin ligase NEDD4-2 (GA20-00058S)

Ubiquitin E3 protein ligase Nedd4-2 belongs to the physiological regulators lining the distal part of the kidney tubule. The mutations in the Nedd4-2 gene of Nedd4-2 is negatively regulated by the presence of vasopressin or...

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 8 836 tis. Kč
    • •
  • 8 836 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 5 302