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1 703 (0,109s) •

Project

The role of serotonin and noradrenaline reuptake inhibitors as potential antidotes for intoxications with dangerous synthetic drugs 2C-B and DOB ? pharmacokinetics, behavioral and QEEG effects (NS10374)

on the pharmacokinetics of 2C-B and DOB in animals. These antidepressants will decrease tissue levels of the method for 2C-B and DOB detection usable in the clinical practice Ad 3) Analysis of behavioral changes i...

FP - Ostatní lékařské obory

  • 2009 - 2011
    • •
  • 5 344 tis. Kč
    • •
  • 5 344 tis. Kč
    • •
  • MZ
Project

Animal study based on studying mechanism of action of new synthetic drug 2C-B and comparaison with common psychotropic substances (LSD, MDMA, psilocin and mescaline) potential risks, implications (NR8785)

of acoustic startle reaction induced by new synthetic drug 2C-B. Identification. Comparaison of behavioral effects of 2C-B with other common illegal substances in reward system and potential risks of addictive pot...

FP - Ostatní lékařské obory

  • 2006 - 2008
    • •
  • 8 780 tis. Kč
    • •
  • 7 507 tis. Kč
    • •
  • MZ
Project

Role of metabotropic mGlu2/3 a AMPA glutamatergic receptors in neurobiology of schizophrenia (NS10375)

in pharmacological serotonergic model of psychosis (2C-B) 6. the influence of ionotropic changes in pharmacological serotonergic model of psychosis (2C-B)......

FL - Psychiatrie, sexuologie

  • 2009 - 2011
    • •
  • 5 059 tis. Kč
    • •
  • 5 059 tis. Kč
    • •
  • MZ
Project

Atomic-resolution characterization of microtubule associated protein 2c (MAP2c) and of modifications regulating its function (GA15-14974S)

associated protein 2c (MAP2c), a 49 kDa IDP involved in an early step of neurite...

BO - Biofyzika

  • 2015 - 2018
    • •
  • 6 460 tis. Kč
    • •
  • 6 460 tis. Kč
    • •
  • GA ČR
Project

Interactions defining physiological functions of Microtubule Associated Protein 2c at atomic resolution (GA20-12669S)

Microtubule associated protein 2c (MAP2c) is a key factor regulating microtubule dynamics in developing brain neurons, and an example of an intrinsically disordered proteins with an important physiological function and detectable structure-f...

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 6 007 tis. Kč
    • •
  • 6 007 tis. Kč
    • •
  • GA ČR
Project

Study of domain interactions of intrinsically disordered protein MAP2c (Microtubule-Associated Protein 2c) with its binding partners via computational methods and nuclear magnetic resonance (LTC17078)

The main focus of this project is MAP2c (Microtubule-Associated Protein 2c) protein, an IDP regulating structure and dynamics (polymerization and degradation) of microtubules (MTs) which is essential for correct function of cytoskeleton of n...

CE - Biochemie

  • 2017 - 2019
    • •
  • 1 425 tis. Kč
    • •
  • 1 425 tis. Kč
    • •
  • MŠMT
Project

Development of LiFePO4 rechargeable batteries for stationary applications (TK05020019)

The goal of the project is the qualitative upgrade of LiFePO4 (LFP) rechargeable batteries by improving the parameters of the developed prismatic and pouch batteries compared to conventional solutions. Prismatic batteries, as the main type of equipme...

Energy and fuels

  • 2023 - 2025
    • •
  • 21 822 tis. Kč
    • •
  • 11 976 tis. Kč
    • •
  • TA ČR
Project

Fatigue life estimation from temperature measurements of additively manufactured specimens to decrease costs using the artificial intelligence (LUABA22071)

performed with these outputs for each of the twenty planned series: a) S-N curve b completely the required parameters of the fabrication of the tests (items 2a-2c above......

Applied mechanics

  • 2022 - 2024
    • •
  • 1 201 tis. Kč
    • •
  • 1 201 tis. Kč
    • •
  • MŠMT
Project

Collaboration with CIMMYT on the study of diversity and evolution of maize B chromosome (LTT19007)

Aim of the proposed project is analysis of B chromosome diversity in maize (Zea on B chromosome and its evolution. The effect of B chromosome on phenotype of host of available germplasm bank accessions for presence of ...

Plant sciences, botany

  • 2019 - 2023
    • •
  • 5 979 tis. Kč
    • •
  • 5 979 tis. Kč
    • •
  • MŠMT
Project

Evolution of holocentric chromosomes (GA13-29362S)

An adaptive origin of holocentric chromosomes (without localized centromere) as a defense against centromere drive will be analyzed using selection regimes acting on kinetochore proteins. To explain surprisingly negative 2C/2n correlation an...

EF - Botanika

  • 2013 - 2016
    • •
  • 9 996 tis. Kč
    • •
  • 9 996 tis. Kč
    • •
  • GA ČR
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