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4 048 (0,175s) •

Project

Construction of a synthetic metabolic pathway for degradation of important environmental pollutant using protein and metabolic engineering (GAP503/12/0572)

Anthropogenic compound 1,2,3-trichloropropane (TCP) is released into the environment as a result of its manufacture and use as a solvent. Since its half-life under groundwater conditions is estimated to be up to 100 years, TCP is likely to p...

DJ - Znečištění a kontrola vody

  • 2012 - 2016
    • •
  • 8 980 tis. Kč
    • •
  • 8 980 tis. Kč
    • •
  • GA ČR
Project

Role of the 14-3-3 protein in the regulation of phosducin function (GAP305/11/0708)

The main goal is to study the structural basis for the 14-3-3 protein-dependent and Ser73 and the binding to the regulatory 14-3-3 protein. The detailed mechanism of the 14-3-3 protein-dependent i...

EB - Genetika a molekulární biologie

  • 2011 - 2015
    • •
  • 6 340 tis. Kč
    • •
  • 6 340 tis. Kč
    • •
  • GA ČR
Project

Study of the interaction between 14-3-3 protein and regulator of G protein signaling RGS3. (IAA501110801)

The main goal of this project is to understand the structural basis of 14-3-3 protein?dependent regulation of function of RGS3 protein. 14-3-3 proteins known to be 14-3-3 binding partners. The rol...

BO - Biofyzika

  • 2008 - 2012
    • •
  • 5 095 tis. Kč
    • •
  • 5 095 tis. Kč
    • •
  • AV ČR
Project

Molecular basis of regulation of cyclin-dependent kinase CDK16 by 14-3-3 proteins (GA25-15222S)

to a complex of phosphorylated cyclin Y (pCCNY) with 14-3-3 proteins. Thus, CDK16. Additionally, CDK16 also directly interacts with 14-3-3 proteins, although the function mechanism of CDK16 regulation and the role...

Biochemistry and molecular biology

  • 2025 - 2027
    • •
  • 12 110 tis. Kč
    • •
  • 12 001 tis. Kč
    • •
  • GA ČR
Project

Role of the phosphorylation and the 14-3-3 protein binding in the regulation of signaling complexes function (GA204/06/0565)

The overall goal of this project is to understand the structural basis of 14-3-3 protein-dependent regulation of function of two biologically important signaling complexes: 14-3-3 protein/forkhead transcription fac...

BO - Biofyzika

  • 2006 - 2008
    • •
  • 2 802 tis. Kč
    • •
  • 2 802 tis. Kč
    • •
  • GA ČR
Project

Study of the molecular mechanism of 14-3-3 isoform binding specificity (KJB5011308)

The 14-3-3 proteins are a family of regulatory molecules, which specifically, the 14-3-3 proteins play key regulatory roles in signal transduction, cell cycle of 14-3-3 isoform binding specificity...

CE - Biochemie

  • 2003 - 2005
    • •
  • 2 578 tis. Kč
    • •
  • 2 004 tis. Kč
    • •
  • AV ČR
Project

14-3-3 protein dependent regulation of caspase-2 (GA17-00726S)

. Phosphorylated procaspase-2 (proC2) binds to the 14-3-3 protein and this interaction blocks mechanism we propose to: i) verify sites responsible for the 14-3-3 protein binding to proC2, ii) perform biophysical ch...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 8 069 tis. Kč
    • •
  • 7 580 tis. Kč
    • •
  • GA ČR
Project

Study of the role of 14-3-3 proteins in the regulation of Forkhead transcription factor AFX activity (GA204/03/0714)

The 14-3-3 proteins have attracted substantial attention over the past few years because of their diverse biological effects. In particular, 14-3-3 proteins cycle control,and nutrient-sensing pathways. 14-3

CE - Biochemie

  • 2003 - 2005
    • •
  • 2 623 tis. Kč
    • •
  • 2 623 tis. Kč
    • •
  • GA ČR
Project

Molecular basis of the 14-3-3 protein-dependent regulation of protein kinase activity (GA19-00121S)

14-3-3 proteins, a family of highly conserved dimeric proteins ubiquitously of how the 14-3-3 proteins regulate the activity of these protein kinases is, in most to investigate the molecular mechanisms underlying t...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 8 340 tis. Kč
    • •
  • 8 034 tis. Kč
    • •
  • GA ČR
Project

Study of carcinogenic potential of the environmental pollutant 3-nitrobenzanthrone for humans (GA303/05/2195)

The aromatic nitroketone 3-nitrobenzanthrone (3-NBA, 3-nitro-7//-benz[3-NBA was detected in surface soil and rainwater, suggesting that 3-NBA is an ubiquitous environm...

CE - Biochemie

  • 2005 - 2007
    • •
  • 1 189 tis. Kč
    • •
  • 1 189 tis. Kč
    • •
  • GA ČR
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