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434 (0,083s) •

Project

Deciphering molecular details of the stringent decoding of the AUG start codon during eukaryotic translation initiation. (GAP305/10/0335)

for decoding. The 40S ribosome has to scan the mRNA’s 5' UTR in its search for the AUG 1A and 1 regulates conformational transitions of the 40S ribosome recognition. These signals originate from mutual interaction...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 7 008 tis. Kč
    • •
  • 7 008 tis. Kč
    • •
  • GA ČR
Project

Crossing the boundaries analysis of functional mRNA elements determining the mechanism of translational reinitiation in lower and higher eukaryotes. (GA15-10116S)

of these short uORFs to retain 40S ribosomal subunits on the same mRNA molecule even after they have been translated, so that 40S can resume scanning for the next start codon. Two......

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 6 795 tis. Kč
    • •
  • 6 795 tis. Kč
    • •
  • GA ČR
Project

eIF3 at the Tip of the AUG Recognition Process in Humans (GA24-10013S)

a potentially toxic peptide. In eukaryotes, the 40S ribosome must scan the mRNA’s 5' UTR originating from mutual interactions between mRNA, the 40S ribosome and specific......

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 13 443 tis. Kč
    • •
  • 13 443 tis. Kč
    • •
  • GA ČR
Project

Molecular basis of the gene-specific translational control mechanism of yeast GCN4 and its mammalian functional homologue ATF4. (GAP305/11/0172)

manner. It is based on an ability of the 40S ribosome to resume scanning after of both genes enables resumption of scanning of post-termination ribosomes and 2......

EB - Genetika a molekulární biologie

  • 2011 - 2016
    • •
  • 7 668 tis. Kč
    • •
  • 7 668 tis. Kč
    • •
  • GA ČR
Project

Global and transcript-specific analysis of translational control in disease. (GX19-25821X)

manipulated on a transcriptome-wide scale by the 80S ribosome profiling. We will also develop and apply variants of ribosome profiling to 1) monitor changes of 40S subunit......

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 45 840 tis. Kč
    • •
  • 45 840 tis. Kč
    • •
  • GA ČR
Project

Ribosomal stress mechanisms and relevance to cancer (GA17-14743S)

Protein translation is performed by ribosomes, complex macromolecular machines comprised of ribosomal proteins and ribosomal RNAs. Synthesis of ribosomes consumes and proliferation. Ribosome biogenesis is ...

FD - Onkologie a hematologie

  • 2017 - 2019
    • •
  • 10 734 tis. Kč
    • •
  • 9 987 tis. Kč
    • •
  • GA ČR
Project

Yeast model organism of aging and apoptosis (MEB060816)

Description of ribosomal proteins ? ribosomal profil, during the aging process of yeast model system...

EB - Genetika a molekulární biologie

  • 2008 - 2009
    • •
  • 93 tis. Kč
    • •
  • 93 tis. Kč
    • •
  • MŠMT
Project

Ribosome biogenesis in apoptosis and aging (MEB061009)

The study of apoptosis and ribosome associated cellular aging will be used in this research proposal to investigate the effect of ribosome biogenesis on these processes the effect of gene dosage variation of selected regulators of <...

EB - Genetika a molekulární biologie

  • 2010 - 2011
    • •
  • 90 tis. Kč
    • •
  • 90 tis. Kč
    • •
  • MŠMT
Project

Structural basis for bacterial ribosome rescue and recycling (8J18DE010)

1. Cryo-EM structure of ArfA bound to a non-stop ribosome The goal of this project is to ascertain how ArfA initially binds to the non-stop ribosomes before recruiting RF2. In particular, how ArfA distinguishes non-stop ribosome...

Cell biology

  • 2018 - 2019
    • •
  • 66 tis. Kč
    • •
  • 66 tis. Kč
    • •
  • MŠMT
Project

Structure and dynamics of the ribosome exit tunnel (GJ19-06479Y)

The ribosome is a huge biomolecular complex, which catalyzes peptide bond is produced. The catalytic site is buried deep in the large ribosomal subunit. Hence, the newly synthesized protein - the nascent chain - leaves the ribos...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 3 611 tis. Kč
    • •
  • 3 611 tis. Kč
    • •
  • GA ČR
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