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8 (0,891s) •

Project

ANCA-associated vasculitis and silica exposure (NI6308)

The vasculitis associated with antineutrophil cytoplasmic antibodies (AAV) are life-threatening diseases with unknown etiology. Recently, the possible association between silica exposure and AAV has been suggested. This project is f...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2000 - 2002
    • •
  • 1 357 tis. Kč
    • •
  • 1 357 tis. Kč
    • •
  • MZ
Project

Advanced genome editing Extracellular vesicle in disease modelling and mouse models development (LUC23175)

addresses extracellular vesicles (EVs) and adeno-associated viruses (AAVs). We have secondary cell cultures, enabling the co-production of AAVs from AAV-packaged cells. The EV-AAV composite particles were tested ...

Genetics and heredity (medical genetics to be 3)

  • 2023 - 2026
    • •
  • 4 500 tis. Kč
    • •
  • 4 500 tis. Kč
    • •
  • MŠMT
Project

Induction of pyroptosis in cancer cells - potential therapeutic method for pancreatic cancer (FW01010527)

Project is focused on development of innovative agent for curing pancreatic cancer. Developed agent will be based on induction of proinflammatory cell death - pyroptosis - in pancreatic cancer cells. Adeno-associated viral vectors (AAV) will...

Biochemistry and molecular biology

  • 2020 - 2024
    • •
  • 11 252 tis. Kč
    • •
  • 6 072 tis. Kč
    • •
  • TA ČR
Project

Gene therapy of neuropathic pain and spasticity via subpial application of AAV vectors in area of spinal cord roots of sciatic nerve and spinal cord injury in minipigs (LTAUSA19029)

Understanding the molecular mechanisms of chronic neuropathic pain and muscle spasticity is hampered by the absence of suitable large animal preclinical models. Due to its size and comparable physiology with a man, the minipig represents a valuable m...

Neurosciences (including psychophysiology)

  • 2020 - 2023
    • •
  • 11 385 tis. Kč
    • •
  • 11 385 tis. Kč
    • •
  • MŠMT
Project

Pathogenic mechanism and novel therapeutic approaches for plectin-related muscular dystrophy (GA25-15690S)

and test two novel approaches based on AAV-mediated P1f delivery and CRISPR/Cas9...

Genetics and heredity (medical genetics to be 3)

  • 2025 - 2027
    • •
  • 10 074 tis. Kč
    • •
  • 10 074 tis. Kč
    • •
  • GA ČR
Project

Genome editing to treat Stargardts disease – Generation and phenotyping of a porcine model and development of a treatment approach (GC19-09628J)

Minipig represents unique, biomedical model thanks to its size and comparable physiological parameters with a man. Also the retina architecture is optimized for daily vision with the high concentration of cones in both species. Therefore we decided t...

Health-related biotechnology

  • 2019 - 2022
    • •
  • 12 272 tis. Kč
    • •
  • 12 002 tis. Kč
    • •
  • GA ČR
Project

Can activation of transcription factor Nrf2 attenuate oxidative stress and its consequences following status epilepticus? (GA18-07908S)

Status epilepticus (SE), both in adult and immature brain, is associated with oxidative stress, mitochondrial dysfunction and inflammation.The aim of the project is to determine whether Nrf2/ARE signaling pathway could serve as a therapeutic target i...

Neurosciences (including psychophysiology)

  • 2018 - 2022
    • •
  • 5 683 tis. Kč
    • •
  • 5 056 tis. Kč
    • •
  • GA ČR
Project

Delineating the role of HTT Cis-Variants in the pathogenesis of Huntington disease (9F24002)

Huntington disease (HD) is a fatal neurodegenerative disorder without disease modifying therapies. It is well known that HD is always caused by an expanded CAG repeat in the huntingtin (HTT) gene leading to translation of a mutant HTT (mHTT) protein ...

Other clinical medicine subjects

  • 2024 - 2027
    • •
  • 5 918 tis. Kč
    • •
  • 5 918 tis. Kč
    • •
  • MŠMT
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