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2 834 (0,081s) •

Project

Characterization of novel ABC transporters in monocots (LH13069)

the functional characterization of specific ATP Binding Cassette (ABC) transporters from characterize barley ABC transporters that are orthologs of Atwbc19, an Arabidopsis ABC transporter that wa...

EB - Genetika a molekulární biologie

  • 2013 - 2015
    • •
  • 1 854 tis. Kč
    • •
  • 1 854 tis. Kč
    • •
  • MŠMT
Project

Influence of transport and metabolism of used and novel taxanes on effects and their mechanisms in patients and tumor cell lines (NR9426)

The assessment of expression fo ABC transporters which cause MDR resistance of established therapy with paclitaxel and doxorubicin, which are ABC substrates. Suggestionof more effective treatment with drigs which are to

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 5 722 tis. Kč
    • •
  • 5 226 tis. Kč
    • •
  • MZ
Project

In-vitro study of molecular-genetic cuase of cell resistance against selected drugs (1A8696)

cell-line, the specific role of ABC transporters in emerging drug resistance to over-express selected ABC transporter will be used in functional study and the specific substrate transport will be determin...

EB - Genetika a molekulární biologie

  • 2005 - 2008
    • •
  • 7 196 tis. Kč
    • •
  • 6 751 tis. Kč
    • •
  • MZ
Project

PET analyses of ABC transporter function for diagnostics and stratification of dementia patients (8F21002)

The main output of this project will be the possibility to identify patient cohorts that have an impairment of the blood-brain barrier export function due to ABCC1 and/or ABCA7 deficiency, and would benefit from activation therapy (precision medicine...

Other medical science

  • 2021 - 2023
    • •
  • 5 612 tis. Kč
    • •
  • 5 612 tis. Kč
    • •
  • MŠMT
Project

Overcoming Natural and Multidrug Resistance by Tumor-Selective Delivery of ABC Transporter/Bcl-2 Inhibitors or Therapeutic Gene under PEG-3 Promoter (GAP301/12/1254)

of ABC transporters, mainly P-glycoprotein. Tumor cells can also overexpress bcl-2 and these are usually derived from tissues with natural expression of some ABC transporter. Here, we inhibitor of ABC

FD - Onkologie a hematologie

  • 2012 - 2016
    • •
  • 21 980 tis. Kč
    • •
  • 21 980 tis. Kč
    • •
  • GA ČR
Project

Resistance of breast and ovarian cancer to cytostatics due to ABC transporters and relation of kinesins to prognosis and prediction (NS9803)

It a large cohort of patients we hope to confirm our findings that high expression and polymorfim of MDR1 cause lower effects of taxane and doxorubicin chemotherapy in breast cancer and extend the study to other ABC transporters (MR...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 8 236 tis. Kč
    • •
  • 8 236 tis. Kč
    • •
  • MZ
Project

Alcohol and regulation of lipoprotein metabolism (NR7847)

The effect of alcohol consumption on expression of genes involved in regulation of lipoprotein metabolism (apolipoprotein A-I, ABC A1 transporter, lipoprotein lipase) will be studied in C57BL/6 mice. The role of genetic predispositi...

ED - Fyziologie

  • 2004 - 2006
    • •
  • 1 623 tis. Kč
    • •
  • 1 455 tis. Kč
    • •
  • MZ
Project

The molecular mechanism of antibiotic resistance conferred by proteins of ARE subfamily of Class 2 ABC proteins (GJ15-16225Y)

The project is aimed to describe the molecular mechanism of resistance conferred by ARE subfamily of ABC proteins. Although this group includes clinically to constitute a functional transporter. Also, the combination of the two mech...

EE - Mikrobiologie, virologie

  • 2015 - 2019
    • •
  • 6 676 tis. Kč
    • •
  • 6 676 tis. Kč
    • •
  • GA ČR
Project

ROLE OF CANALICULAR MEMBRANE TRANSPORTERS IN CHOLESTATIC LIVER DISEASES (NM7510)

A search for mutations in genes encoding canalicular membrane transporters of bile salts, phospholipids and bile pigments will be performed in patients with chronic inrahepatic cholestasis and Rotor syndrome. In addition to that a group for ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 2 858 tis. Kč
    • •
  • 2 845 tis. Kč
    • •
  • MZ
Project

Critical residues important for the resistance phenotype of proteins of ARE family of ABC transporters and molecular mechanism of its function (GPP302/12/P632)

clinically important resistance protein, Msr(A), a member of ARE family of ABC proteins...

EE - Mikrobiologie, virologie

  • 2012 - 2014
    • •
  • 940 tis. Kč
    • •
  • 940 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 2 834