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28 (0,059s) •

Project

Prenatal treatment of achondroplasia (NU23-10-00550)

Achondroplasia (ACH) is the most common genetic form of human dwarfism, caused by activating mutations in receptor tyrosine kinase FGFR3. ACH is severe dwarfism and spinal skeletal structures. In 2021, the vosoritide was approved fo...

Cell biology

  • 2023 - 2026
    • •
  • 15 116 tis. Kč
    • •
  • 15 116 tis. Kč
    • •
  • MZ
Project

Affordable and accessible Redefining the future of achondroplasia treatment with repurposed FGFR inhibitors (NW25-10-00107)

Achondroplasia (ACH) is the most common genetic form of human skeletal. ACH is a severe dwarfism with an adult height of about 140 cm and skeletal is approved for ACH and improves longitudinal growth but not cranial malform...

Medicinal chemistry

  • 2025 - 2028
    • •
  • 12 008 tis. Kč
    • •
  • 12 008 tis. Kč
    • •
  • MZ
Project

Relationship between structure of acetylcholinesterase reactivators and their reactivation potency (GP305/07/P162)

of anticholinergics (atropine mainly) and acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, methoxime or HI-6). Due to the fact that currently available AChE reactivators are not able to reactivate AChE inh...

FR - Farmakologie a lékárnická chemie

  • 2007 - 2009
    • •
  • 963 tis. Kč
    • •
  • 963 tis. Kč
    • •
  • GA ČR
Project

The physiological importance of erythrocyte acetylcholinesterase and its contribution to the development of intoxication with AChE inhibitors (IZ4074)

FP - Ostatní lékařské obory

  • 1997 - 1998
    • •
  • 217 tis. Kč
    • •
  • 217 tis. Kč
    • •
  • MZ
Project

Mechanism and possibilities of pharmacological intervention in presynaptic regulation of acetycholine release (GA305/98/0469)

The postsynaptic effects of acetylcholine (ACh) in the brain are mostly mediated by muscarinic receptors. The release of ACh from the cholinergic nerve of the effects of these receptors on the release of ACh, and the possib...

ED - Fyziologie

  • 1998 - 2000
    • •
  • 2 887 tis. Kč
    • •
  • 2 470 tis. Kč
    • •
  • GA ČR
Project

Novel inhibitors of acetylcholinesterase derived from 7-MEOTA - potential Alzheimer´s disease drugs (GAP303/11/1907)

consist in synthesis and evaluation of  novel acetylcholinesterase (AChE) inhibitors derived from 7-MEOTA as potential AD drugs. Synthesized AChE inhibitors will be tested of AChE inhibitors, antioxidant evaluation of nove...

FR - Farmakologie a lékárnická chemie

  • 2011 - 2015
    • •
  • 10 402 tis. Kč
    • •
  • 10 402 tis. Kč
    • •
  • GA ČR
Project

Countermeasure against chemical terrorism - development of new antidotes against nerve agents (ME 865)

searching for the most spreaded pesticides as potentional nerve agents, test of ability to inhibite in vitro enzyme Acetylcholinesterase (AChE)......

CA - Anorganická chemie

  • 2006 - 2009
    • •
  • 1 668 tis. Kč
    • •
  • 1 668 tis. Kč
    • •
  • MŠMT
Project

Influence of the nerve agent and reactivators of Acetyl Choline Esterase on the Guinea Pig (OVUOFVZ200905)

The aim of this project is determine the physiological activity of Acetyl Choline Esterase (AChE) and detection of LD50 of inhibitors paraoxon, tabun, cyklosarine and reactivators AChE pralidoxim, obidoxim, trimedoxim, HI-6, methoxi...

FP - Ostatní lékařské obory

  • 2009 - 2011
    • •
  • 2 384 tis. Kč
    • •
  • 894 tis. Kč
    • •
  • MO
Project

Concept of non-quaternary reactivators AChE as the antidotes of organophsophorus poisoning - a new hope or a blind way? (GA15-16701S)

Acetylcholinesterase (AChE) reactivators based on pyridinium aldoximes (obidoxime, HI-6) are used as causal antidotes in case of nerve agent or pesticide (BBB) permeation and thus they are not capable to fully reactivate AChE AC...

FR - Farmakologie a lékárnická chemie

  • 2015 - 2017
    • •
  • 6 886 tis. Kč
    • •
  • 6 886 tis. Kč
    • •
  • GA ČR
Project

Novel inhibitors of acetylcholinesterase as prophylaxis of nerve agent poisonings (OVUOFVZ200805)

This project is focused on finding of suitable reversible acetylcholinesterase inhibitor as a replacement of prophylactic drug pyridostigmine. For this purpose, 100 reversible ACHE inhibitors will be prepared, evaluated in vitro and compared...

FP - Ostatní lékařské obory

  • 2008 - 2011
    • •
  • 1 805 tis. Kč
    • •
  • 1 265 tis. Kč
    • •
  • MO
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