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3 192 (0,108s) •

Project

The role of AT2 angiotensin II receptors in blood presure control and in the pathogenesis of two-kidney, one-clip Goldblatt hypertension (IAB5203201)

that activation of AT2 receptors physiologically antagonizes the effects of ANG II caused by AT1 receptor activation. The aim of our study is to determine whether or not AT2 of hypertension. For this purp...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2002 - 2004
    • •
  • 859 tis. Kč
    • •
  • 280 tis. Kč
    • •
  • AV ČR
Project

The role of angiotensin II type 2 receptors in the pathophysiology of renovascular hypertension (GA305/07/0167)

of the RAS is angiotensin II (ANG II) acting via two main receptors, namely AT1 and AT2 receptors. Most "classical" biological effects of ANG II (vasoconstriction, increased actionof ANG II

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2007 - 2009
    • •
  • 3 296 tis. Kč
    • •
  • 3 296 tis. Kč
    • •
  • GA ČR
Project

The role of the interaction of the AT1 and AT2 angiotensin II receptors in the ontogenesis of hypertension a study in "Ren-2" transgenic rats (NR8550)

The role of the interaction of the AT1 and AT2 angiotensin II receptors in the ontogenesis of hypertension will be studied in the model of "Ren-2" transgenic rats.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2005 - 2007
    • •
  • 4 838 tis. Kč
    • •
  • 4 728 tis. Kč
    • •
  • MZ
Project

Angiotensin II receptor conformation and the design-synthesis of therapeutically useful drugs against hypertension and cardiovascular diseases (OK 170)

FR - Farmakologie a lékárnická chemie

  • 1996 - 1997
    • •
  • 759 tis. Kč
    • •
  • 445 tis. Kč
    • •
  • MŠMT
Project

Acute and chronic effects of non-peptide angiotensin II receptor antagonist and angiotensin converting enzyme inhibitor on blood pressure,insulin sensitivity an (IZ3059)

FR - Farmakologie a lékárnická chemie

  • 1995 - 1997
    • •
  • 1 008 tis. Kč
    • •
  • 955 tis. Kč
    • •
  • MZ
Project

The effect of non-peptide angiotensin II receptor antagonist on experimental ischemic renal injury (IZ4174)

The study follows the aim to survey possibilities of pharmacological influence on renal ischemic injury in rats by means of non-peptide angiotensin II receptor antagonist and to try to find an optimum schema for its use within clini...

FJ - Chirurgie včetně transplantologie

  • 1997 - 1999
    • •
  • 2 127 tis. Kč
    • •
  • 1 823 tis. Kč
    • •
  • MZ
Project

Signal transduction of angiotensin II in diabetes mellitus and its modulation by glucose, insulin a insulin resistance (NR8221)

receptor, factors important for smooth Ang II signaling. Furthermore, we will determine activities of signaling cascades that are activated by Ang II in parallel with insulinAngiotensin II (Ang II) plays ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 5 049 tis. Kč
    • •
  • 4 585 tis. Kč
    • •
  • MZ
Project

The roles of renin-angiotensin and endothelin systems in the pathophysiology of ANG II-dependent hypertension (GC305/07/J004)

of ANG II, do not. In addition, it has been shown that ETA receptors are responsible that animal models with exogenously administered angiotensin II (ANG II) exhibit an ET and moreover, had substantial impact on b...

ED - Fyziologie

  • 2007 - 2010
    • •
  • 1 537 tis. Kč
    • •
  • 1 537 tis. Kč
    • •
  • GA ČR
Project

Role of the renin-angiotensin system in the control of renal function and blood pressure studies in the "knock-out" mouse with AT1A receptor absence. (NA5291)

In mice with genetically evoked absence of AT-1 receptor for angiotensin II, which cannot respond to own endogenous angiotensin, the role of this autacoid for development and maintenance of blood pressure and renal function will be ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1999 - 2001
    • •
  • 3 349 tis. Kč
    • •
  • 3 349 tis. Kč
    • •
  • MZ
Project

New concept of enhancing receptor targeting with polymer conjugates by reversible anchoring to membranes (GA21-04166S)

for targeting also enzymes or receptors other than GCP II.Within this project, we will develop a conceptually new system for inhibition of glutamate carboxypeptidase II (GCP II) in brain as a treatment tool for su...

Polymer science

  • 2021 - 2023
    • •
  • 10 190 tis. Kč
    • •
  • 9 876 tis. Kč
    • •
  • GA ČR
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