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203 (0,085s) •

Project

DAPIT protein and its role in biogenesis of mitochondrial ATP synthase (GA16-01813S)

FoF1-ATP synthase composed of 15 core structural subunits is the key enzyme of this novel protein for biogenesis of ATP synthase, its structural properties, lipid on better understanding of the DAPIT importance in ...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 6 121 tis. Kč
    • •
  • 5 839 tis. Kč
    • •
  • GA ČR
Project

Mechanism of ATP synthase biogenesis and the role of TMEM70 protein (GAP303/11/0970)

ATP synthase is the key enzyme of mitochondrial energy provision, responsible that are assembled into a functional ATP synthase in a stepwise process that depends on several helper proteins. Recently we have discov...

CE - Biochemie

  • 2011 - 2015
    • •
  • 8 963 tis. Kč
    • •
  • 8 963 tis. Kč
    • •
  • GA ČR
Project

Trangenic and pharmacological complementation of inherited ATP synthase disorders (NV16-33018A)

Inborn deficiency of ATP synthase, the key enzyme of cellular energy provision as it is not absolutely essential for ATP synthase biogenesis and sufficient recovery of ATP production can be expected even a...

FG - Pediatrie

  • 2016 - 2019
    • •
  • 14 567 tis. Kč
    • •
  • 14 567 tis. Kč
    • •
  • MZ
Project

Supramolecular organization of mitochondrial ATP synthase in metabolic regulations (GA17-08565S)

Oligomers of mitochondrial ATP-synthase form cristae edges and determine cristae morphology in relation to metabolism. This relationship will be elucidated antibodies against ATP-synthase subunits; or by homo-FRET ...

EA - Morfologické obory a cytologie

  • 2017 - 2019
    • •
  • 6 594 tis. Kč
    • •
  • 6 462 tis. Kč
    • •
  • GA ČR
Project

Ketogenic diet as a treatment for inborn defects of ATP synthase (NU21-07-00550)

Mitochondrial disorders are among the most prevalent inborn errors of metabolism but largely lack treatments and have poor outcomes. ATP synthase deficiencies to increase in the content of assembled ATP synthase ho...

Biochemistry and molecular biology

  • 2021 - 2025
    • •
  • 9 665 tis. Kč
    • •
  • 9 665 tis. Kč
    • •
  • MZ
Project

In situ visualization of ATPase Inhibitory Factor 1 (IF1) in mitochondrial ultrastructure by high-resolution cryo-electron tomography (GA24-10325S)

ATP synthase is the primary source of cellular ATP, but apart from that also interaction with ATP synthase in situ in the mitochondrial inner membrane of pancreatic β with ATP synthase an...

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 10 049 tis. Kč
    • •
  • 10 049 tis. Kč
    • •
  • GA ČR
Project

Functional analysis of two novel subunits of the F0F1-ATP synthase complex in Trypanosoma brucei (GP204/09/P563)

F0F1-ATP synthase plays an essential role in Trypanosoma brucei, an important and a mammalian host. Interestingly, the function of the mitochondrial (mt) F0F1-ATP synthase differsbetween the insect and mammalian st...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 1 077 tis. Kč
    • •
  • 1 077 tis. Kč
    • •
  • GA ČR
Project

New factors regulating biogenesis of subunit c from mammalian FoF1 ATP synthase (GA20-25768S)

Mitochondrial F1Fo ATP synthase is the key enzyme of energy provision in most eukaryotic organisms. While its catalytic F1 domain is conserved throughout evolution to interact with subunit c. Of those, TMEM70 is already identified <...

Cell biology

  • 2020 - 2023
    • •
  • 6 786 tis. Kč
    • •
  • 6 786 tis. Kč
    • •
  • GA ČR
Project

The role of ATP synthase structure in the biogenesis and bioenergetics of the unique Trypanosoma brucei mitochondrion (GA18-17529S)

- the presence of ATP synthase dimer rows at the crista ridges. Little is known about and ATP-producing mitochondrion transitions to a streamlined tubular, cristae-lacking and ATP-consuming organelle. Combining tr...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 6 731 tis. Kč
    • •
  • 6 512 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial diseases caused by inherited disorders of ATP synthase (NR7790)

Characterization of molecular etiopathogenic mechanisms of mitochondrial diseases that are caused by specific defects of mitochondrial ATP synthase due to different mutations in mtDNA ATP6 gene, or by nuclear defects affecting biosy...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 6 285 tis. Kč
    • •
  • 4 359 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 203