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Projects

9 459 projects (0,233s) •

Project

Analysis of plant gene regulation systems by constitutive gene activation (GA204/97/0154)

thaliana by constitutive gene activation with the use of 35S promotor. It is planned will beused. Three types of mutations will be scored in the offspring: 1. Flower morphoregulatory mutations. 2. Toot morphoregulatory

EB - Genetika a molekulární biologie

  • 1997 - 1999
    • •
  • 4 900 tis. Kč
    • •
  • 3 042 tis. Kč
    • •
  • GA ČR
Project

Targets and consequences of activation-induced cytidine deaminase-mediated mutagenesis in tumours (GN24-11338I)

Activation-induced cytidine deaminase (AID) causes mutations in immunoglobulin genes of activated B cells and is required for the production of high-affinity antibodies. However, AID also causes mutations in non-im...

Cell biology

  • 2024 - 2027
    • •
  • 6 323 tis. Kč
    • •
  • 6 323 tis. Kč
    • •
  • GA ČR
Project

Mutation analysis in inherited metabolic neurodegenerative diseases with childhood onset (NR8351)

DNA-diagnosis will enable mutation characterization in probands gene. Patients with publications of other authors. Probands mutations will be identified by sequencing will serve for genotyping of family members. Knowledge of the

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 4 516 tis. Kč
    • •
  • 4 515 tis. Kč
    • •
  • MZ
Project

Changes in coagulation parameters monitored in the course of physiological pregnancy and pregnancy of carriers of thrombophilic mutations. (NS9905)

of thrombophilic mutations. The aim of the study is to specify the diagnosis of coagulation activation by introducing the new method of assesment thrombin generation during with heparins. The study determinates the incidence of car...

FK - Gynekologie a porodnictví

  • 2008 - 2011
    • •
  • 2 888 tis. Kč
    • •
  • 2 888 tis. Kč
    • •
  • MZ
Project

Significance of TACI mutations and lymphocyte subpopulations in pathogenesis of selective IgA deficiency (NS10398)

of TACI mutations will be determined in IgAD patients and in a healthy Czech population. Although the TACI mutations were shown to be increased in patients mutation in IgAD patients. The lymphocyte subpopulations which wer...

EC - Imunologie

  • 2009 - 2011
    • •
  • 3 035 tis. Kč
    • •
  • 3 035 tis. Kč
    • •
  • MZ
Project

Cooperativity of nicotinic receptors (GA202/09/0806)

neighboring subunits. The activation of receptors will be influenced by point mutations activated from two or more cooperating binding sites. Binding sites occupation. The changes in activation, desensitization an...

BO - Biofyzika

  • 2009 - 2012
    • •
  • 4 214 tis. Kč
    • •
  • 4 214 tis. Kč
    • •
  • GA ČR
Project

Explaining metastatic potential of colorectal cancer through whole-exome sequening and immune cell and telomere landscape (GA23-05609S)

sequencing (WES). We search for critical mutations and mutation signatures that are associated with the metastatic process. Numbers of mutations (tumor mutation burden) is also assessed as it is related to act...

Oncology

  • 2023 - 2025
    • •
  • 12 109 tis. Kč
    • •
  • 12 109 tis. Kč
    • •
  • GA ČR
Project

The relationship of the androgen receptor gene mutations and changes in the androgen receptor expression in prostate cancer to the biological properties of the tumor and to the hormonal profile (NR8096)

The project is focused on the determination of the relationship of the androgen receptor gene mutations and changes in the AR expression in localized prostate cancer to the histopathological properties of the tumour and to the androgen conce...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 3 119 tis. Kč
    • •
  • 3 110 tis. Kč
    • •
  • MZ
Project

Epigenetic, genetic and molecular factors required for mutagenesis of oncogene BCR-ABL1 during Ph+ cells treatment with tyrosine kinase inhibitor (GA18-18407S)

inhibition of BCR-ABL1 kinase activity by specific inhibitors (TKI), preferentially by imatinib in the first line treatment. Mutations in the BCR-ABL1 kinase domain represent, that development of TKI resistance by acquisition of BC...

Biochemical research methods

  • 2018 - 2021
    • •
  • 10 249 tis. Kč
    • •
  • 9 100 tis. Kč
    • •
  • GA ČR
Project

New technology for correction of mutations in monogenetic diseases by targeted reparation of mutations using specific nucleases (NT14451)

on special therapeutical targeting of mutations causing monogenetic diseases. This technology relies on transcription activator-like effector nucleases (TALENs TALEN-technology to resemble better the human mutations; the c...

EB - Genetika a molekulární biologie

  • 2013 - 2015
    • •
  • 7 803 tis. Kč
    • •
  • 7 803 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 9 459