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764 (0,207s) •

Project

Introduction and use of new array-CGH technology for precise determination of copy changes in patients suffering from acute myeloid and lymphoblastic leukemia (NE7644)

of human DNA for changes in copy number of specific sequences in patients with acute leukemia. Use of array-CGH technique in patients suffering from acute myeloid and lymphoblastic leukemia with normal ka...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 3 671 tis. Kč
    • •
  • 3 656 tis. Kč
    • •
  • MZ
Project

New molecular markers for monitoring of residual disease in acute myeloid leukemia patients (NS10632)

New molecular markers for monitoring minimal residual disease in patients with acute myeloid leukemia (AML). Quantitative determination of gene expression, mutation, and methylation in samples from AML patients. Evaluation ...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 7 576 tis. Kč
    • •
  • 7 576 tis. Kč
    • •
  • MZ
Project

New molecular markers of residual disease in acute myeloid leukemia patients and of disease progression in myelodysplastic patients, and prediction of STI-571 responsiveness in chronic myeloid (NR8748)

New molecular markers of residual disease in acute myeloid leukemia patients and of disease progression in myelodysplastic patients, and prediction of STI-571 responsiveness in chronic myeloid leukemia pat...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 6 316 tis. Kč
    • •
  • 5 783 tis. Kč
    • •
  • MZ
Project

Determination of functional status of tumor suppressor p53 in acute myeloid leukemia by using of method FASAY. (NC6395)

The project concentrates on determination of functional status of tumor suppressor p53 in cells of patients with acute myeloid leukemia by functional method called FASAY,which is based on measuring of transactivation abilit...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 3 383 tis. Kč
    • •
  • 3 383 tis. Kč
    • •
  • MZ
Project

Molecular diagnostics of chronic myeloid leukemia and acute promyeloid leukemia. (IZ3563)

FD - Onkologie a hematologie

  • 1996 - 1998
    • •
  • 1 719 tis. Kč
    • •
  • 1 569 tis. Kč
    • •
  • MZ
Project

Detection and monitoring of certain chromosomal abnormalities in children suffering from acuta myeloid leukemia (NC4547)

The nested reverse trancriptase polymerase chain reaction improves both detection and long-term monitoring of selected chromosomal abnormalities in childhood acute myeloid leukemia.......

FD - Onkologie a hematologie

  • 1998 - 2000
    • •
  • 1 201 tis. Kč
    • •
  • 1 201 tis. Kč
    • •
  • MZ
Project

The role of RUNX1, EVI1 and CEBPA genes in the pathogenesis of leukemias and pre-leukemias (NR9045)

Genomic DNA of members of family with markers of familial platelet disorder with predisposition to acute myeloid leukemia will be examined for mutation in RUNX1 gene. Mutations in genes for transcription factor RUNX1 in AML...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 6 857 tis. Kč
    • •
  • 6 492 tis. Kč
    • •
  • MZ
Project

Molecular prognostic factors in myeloid leukemia (NC7560)

Molecular prognostic factors in patients of acute and chronic myeloid leukemia. Expression of p21 Cip, Fas, FasL, DR 4 and 5, and Wt-1 genes detected at MRNA ( comparative and real-time RT-PCR) and protein level (flow cytom...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 4 870 tis. Kč
    • •
  • 4 796 tis. Kč
    • •
  • MZ
Project

The study of pathogenesis of acute leukemias (AL) with 11q23 chromosomal rearrangement (GA301/01/0489)

The 11q23 chromosomal rearrangement, involving transcription factor MLL, has been implicated in an variety of acute leukemias (AL). The AL with MLL rearrangement are either de-novo or secondary (therapy related) and are associated w...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 4 604 tis. Kč
    • •
  • 4 604 tis. Kč
    • •
  • GA ČR
Project

Improving therapy for childhood ambiguous lineage leukemia (NU23-07-00220)

Acute leukemias, the most frequent malignancy in childhood, can be classified as either lymphoblastic or myeloid. In a small number of cases the lineage source is less clear as the leukemic cells contain features of both ly...

Hematology

  • 2023 - 2026
    • •
  • 13 513 tis. Kč
    • •
  • 13 513 tis. Kč
    • •
  • MZ
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