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30 (0,077s) •

Project

Molecular mechanisms of membrane interaction and translocation of adenylate cyclase toxin from Bordetella pertussis (GA15-09157S)

The multifunctional adenylate cyclase toxin (CyaA) is a key virulence factor of Bordetella pertussis that causes a highly contagious respiratory disease called pertussis or whooping cough. CyaA is a fusion of an N-terminal adenylate...

CE - Biochemie

  • 2015 - 2017
    • •
  • 5 994 tis. Kč
    • •
  • 5 994 tis. Kč
    • •
  • GA ČR
Project

Role of the pore-forming activity in adenylate cyclase toxin action and Bordetella virulence (GAP302/12/0460)

The adenylate cyclase toxin-hemolysin (CyaA) is a multifunctional RTX protein playing a key role in virulence of pathogenic Bordetella. It translocates an adenylate cyclase enzyme into cytosol of host phagocytes and subverts their b...

CE - Biochemie

  • 2012 - 2016
    • •
  • 15 307 tis. Kč
    • •
  • 15 307 tis. Kč
    • •
  • GA ČR
Project

Ursodeoxycholic acid and S - adenyl methion in treatment intrahepatic cholestasis of pregnancy.Biochemical and hematological aspects of the disease menacing mother and fetus. (NH7376)

The project shoud assess the impact of administration of ursodeoxycholic acid and S-adenyl methionin on pregnant with ICP from the viewpoint of suppression of clinical and lab signs of the disorder and safety continunance of pregnancy for fe...

FK - Gynekologie a porodnictví

  • 2003 - 2005
    • •
  • 975 tis. Kč
    • •
  • 946 tis. Kč
    • •
  • MZ
Project

Investigation of the mechanism of membrane translocation of the adenylate cyclase toxin (IAA5020907)

The adenylate cyclase toxin (ACT) paralyses a variety of cells by uncontrolled synthesis of cAMP. Penetration of ACT into cells is a rather iniwue example of spontaneous protein translocation directly across the cellular membrane. Elucidatio...

CE - Biochemie

  • 1999 - 2003
    • •
  • 7 321 tis. Kč
    • •
  • 4 975 tis. Kč
    • •
  • AV ČR
Project

Nature and role(s) of the posttranslational modification(s) required for activities of an RTX toxin the adenylate cyclase toxin of bordetella pertussis (GA310/95/1048)

EE - Mikrobiologie, virologie

  • 1995 - 1997
    • •
  • 1 030 tis. Kč
    • •
  • 1 030 tis. Kč
    • •
  • GA ČR
Project

Deciphering the role of acylated domain in the membrane penetration of Bordetella pertussis adenylate cyclase toxin (GA19-04607S)

The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in virulence of the whooping cough agent Bordetella pertussis. CyaA translocates an AC enzyme into cytosol of CD11b+ phagocytes and subverts their bactericidal functions by unregu...

Microbiology

  • 2019 - 2021
    • •
  • 9 821 tis. Kč
    • •
  • 9 821 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase (IAA5020406)

Penetration of adenylate cyclase toxin (ACT) into target cells is a unique example of direct translocation of a toxic enzyme across the target cytoplasmic membrane. Its understanding is, hence, of general relevance for deciphering the princi...

CE - Biochemie

  • 2004 - 2008
    • •
  • 6 250 tis. Kč
    • •
  • 5 910 tis. Kč
    • •
  • AV ČR
Project

Targeted drug design for bioterrorism prevention. Development of effective inhibitors of the adenylate cyclase toxin of Bordetella pertusis and Bacillus anthracis. (VG20102015046)

inhibitorsof the adenylate cyclase toxin of Bordetella pertusis and Bacillus anthracis...

CC - Organická chemie

  • 2010 - 2015
    • •
  • 41 350 tis. Kč
    • •
  • 41 345 tis. Kč
    • •
  • MV
Project

Molecular mechanism of adenylate cyclase toxin penetration into phagocytes (IAA500200914)

We propose to investigate the mechanistic details of adenylate cyclase toxin (CyaA) penetration across cellular membrane of myeloid phagocytes. Structural requirements for CyaA interaction with the beta-2 integrin receptor CD11b/CD18 and for...

EB - Genetika a molekulární biologie

  • 2009 - 2013
    • •
  • 7 666 tis. Kč
    • •
  • 7 666 tis. Kč
    • •
  • AV ČR
Project

Myocardial adrenergic betareceptor - adenylate cyklase complex in children with heart defects. (IZ2040)

9F - 9

  • 1994 - 1996
    • •
  • 848 tis. Kč
    • •
  • 1 232 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 30