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1 687 (0,155s) •

Project

Vectors for gene therapy targeted on stromal cells of solid tumors (NR9238)

Investigation of an anti-tumor therapeutic DNA vaccine and vectors for gene therapy targeting tumor fibroblasts in mouse model of tumors induced by papilloma expressing the anti-tumor factors and ...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 9 764 tis. Kč
    • •
  • 9 542 tis. Kč
    • •
  • MZ
Project

Potentiation of anti-tumor immunity with cytokine immnocomplexes during treatment with polymer-bound drugs (GP301/07/P192)

and to enhance the induction of anti-tumor immunity established during or shortly after drug doxorubicin are passively accumulated in solid tumors due to the EPR effect taken upby tumor cells. Such conjugates have...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 1 464 tis. Kč
    • •
  • 1 464 tis. Kč
    • •
  • GA ČR
Project

Development of anti-tumor DNA vaccines based on fusion of immunogen with E. coli beta-glucuronidase and enhancement of their effect by stimulation of non-specific immunity (NR9246)

Enhancement of efficacy of therapeutic anti-tumor vaccines based on fusion of a tumor antigen with E. coli beta-glucuronidase. Increase of production of immunogens of immunization effects in mouse tumor models. Enh...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 8 294 tis. Kč
    • •
  • 8 104 tis. Kč
    • •
  • MZ
Project

Development of new therapeutic strategies to improve effectiveness of anti-tumor drugs (ME 292)

FD - Onkologie a hematologie

  • 1998 - 2000
    • •
  • 85 tis. Kč
    • •
  • 85 tis. Kč
    • •
  • MŠMT
Project

Polymer prodrugs acting as endogenous vaccines for synergic tumor therapy using immunomodulation and immune checkpoint blockade (GA17-08084S)

) in tumor microenvironment, and immune checkpoint blockade using anti-CTLA-4 and anti-PDThe principal objective of the project is to study combined tumor treatment enabling their controlled activation in tumor...

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 8 334 tis. Kč
    • •
  • 8 010 tis. Kč
    • •
  • GA ČR
Project

Experimental cancer immunotherapy, tumor heterogeneity, and overcoming tumor immune escape (GA19-00816S)

mechanisms that enable tumor cells to evade anti-tumor immune reactions. To stimulate anti-tumor immunity, adaptive immunity will be induced by DNA immunization and innate immunity, particularly repolariz...

Immunology

  • 2019 - 2022
    • •
  • 8 243 tis. Kč
    • •
  • 8 243 tis. Kč
    • •
  • GA ČR
Project

Polymer conjugates of drugs targeted with specific oligopeptides (GA204/05/2255)

to angiogenic endothelial cells of solid tumor vasculature by specific anti-angiogenic and biological properties of an anti-angiogenic oligopeptide-targeted polymer drug delivery systém intended for site-specific tumor...

CD - Makromolekulární chemie

  • 2005 - 2007
    • •
  • 5 421 tis. Kč
    • •
  • 5 421 tis. Kč
    • •
  • GA ČR
Project

Galectin-positive glioblastoma exosomes new biomarkers and targets for glycoanotherapeutics (NU23-08-00307)

and anti-tumor immune response. The composition of exosomes can reflects pathological, vascularization or oncogenic signaling and anti-tumor immune response. Their spread by exosomes and the associated modulation ...

Oncology

  • 2023 - 2026
    • •
  • 15 509 tis. Kč
    • •
  • 15 509 tis. Kč
    • •
  • MZ
Project

A novel microbial naphtoquinone compounds with anti-cancer properties (GA13-16565S)

as potent inhibitors of tumor growth and inducers of apoptosis/necrosis in cancer cells compound with promising anti-cancer activities. Hence, in this project we will search their anti-cancer properties. Results of this pr...

EE - Mikrobiologie, virologie

  • 2013 - 2016
    • •
  • 9 523 tis. Kč
    • •
  • 9 523 tis. Kč
    • •
  • GA ČR
Project

Detailed analysis of specificity, heterogeneity and role of anti-calreticulin antibodies in oncological and autoimmune diseases. (GA13-14608S)

peptides by ELISA. The influence of anti-CRT antibodies on proliferation of tumor cells, levels and ratio of subtypes of serum anti-calreticulin (CRT) and try to elucidate of IgM, and IgA and IgG anti-CRT antibodi...

FE - Ostatní obory vnitřního lékařství

  • 2013 - 2019
    • •
  • 3 526 tis. Kč
    • •
  • 3 526 tis. Kč
    • •
  • GA ČR
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