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5 350 (0,323s) •

Project

Study of expression and activation of apoptogenic caspases and of levels of their inhibitors in non-small cell lung carcinoma (NC6610)

Study of expression and activation of apoptogennic caspases and of levels of their inhibitors XIAP and survivin in human non-small cell lung carcinoma with the aim to evaluate their correlation with progression of this cancer disease.......

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 3 500 tis. Kč
    • •
  • 3 470 tis. Kč
    • •
  • MZ
Project

Dysfunction of the apoptosome pathway in non-small cell lung cancer (NS9715)

The project is aimed at the study of molecular mechanisms underlying apoptosome pathway dysfunction in non-small cell lung carcinoma (NSCLC) cells and tissues, with using the methods of derepression of apoptosome apparatus activation and activity and...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 5 508 tis. Kč
    • •
  • 5 508 tis. Kč
    • •
  • MZ
Project

Role of Lineage Specific Transcription Factors GATA-1 and PU.1 in Hematopoietic Commitment and Leukemogenesis (GA301/06/1093)

GATA-1 and myeloid PU.1, is thought to transcriptionally regulate lineage commitment in chromatin. PU.1 plays a role in cancer: high levels of transcription factor PU.1 has beenshown to cause erythroleukemia where...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 5 021 tis. Kč
    • •
  • 4 989 tis. Kč
    • •
  • GA ČR
Project

The study of relation between the activity of type - V collagenase and level of s-ICAM1 and s-VCAM1 in sera and synovial fluids to the prognosis of rheumatoid arthritis (NK6332)

A study will be made of the content and activity of gelatinase B and the levels of the soluble forms of immunoglobulins ICAM-1 and VCAM-1 in the blood serum and in the synovial fluid of patients with early rheumatoid arthritis. In t...

FE - Ostatní obory vnitřního lékařství

  • 2000 - 2002
    • •
  • 1 831 tis. Kč
    • •
  • 1 831 tis. Kč
    • •
  • MZ
Project

Sensing of HIV-1 by plasmacytoid dendritic cells dichotomy of immunoreceptor signaling (GA14-32547S)

interferon (IFN-I) in human organism, in pathogenesis of HIV-1 infection is not clear. In contrast to HIV-1 infected lymphocytes, HIV-1 virions are weak inducers of IFN-I. Exposure of pDCs to HIV-1-infected lympho...

EE - Mikrobiologie, virologie

  • 2014 - 2018
    • •
  • 6 397 tis. Kč
    • •
  • 6 397 tis. Kč
    • •
  • GA ČR
Project

Novel regulatory mechanisms of transcription factors PU.1 and GATA-1 in leukemogenesis. (GPP301/12/P380)

determinants such as transcription factor PU.1 regulating most of the hematopoietic target genes. Production of mature blood elements requires connecting PU.1 with secondary determinants such as GATA-1 and other lineage sp...

FD - Onkologie a hematologie

  • 2012 - 2016
    • •
  • 3 726 tis. Kč
    • •
  • 3 726 tis. Kč
    • •
  • GA ČR
Project

Genetic predisposition to osteoporosis. (NB7380)

An analysis of the association between common polymorphisms in the transforming growth factor beta -1, plasminogen-activator inhibitor and collagen type 1 genes and osteoporosis.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 2 574 tis. Kč
    • •
  • 2 573 tis. Kč
    • •
  • MZ
Project

1-fluoro-1-lithioalkanes and 1-fluoro-1lithio-1-alkanes - synthesis, stability study and synthetic applications (GA203/99/1630)

The target of the project is the synthesis of 1-fluoro-1-lithioalkanes of general formula XYCFLi and of 1-fluoro-1-lithio-1-alkenes of general formula WZC=CFLi. The stability of these compounds will be stu...

CC - Organická chemie

  • 1999 - 2001
    • •
  • 965 tis. Kč
    • •
  • 750 tis. Kč
    • •
  • GA ČR
Project

The role of DNA methylation and histone modifications in the establishment and maintenance of HIV-1 latency (GP204/08/P616)

for eradication of HIV-1 infection. We found that CpG methylation of the HIV-1 promoter in 5?LTR is not needed for establishment of HIV-1 latency but controls the stringency oftranscriptional silencing. HIV-1 late...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • GA ČR
Project

Identification of the subtypes and study of genetic variants of HIV-1 in the Czech Republic (NI5174)

Genetic characterization of HIV-1 strains in the Czech Republic. Determination of genetic subtypes, strains resistant to antiretroviral therapy. Comparison of genotypes of the selected HIV-1 strains with their biological properties....

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1999 - 2001
    • •
  • 3 095 tis. Kč
    • •
  • 1 374 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 5 350