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6 284 (0,114s) •

Project

Complex analysis of p53 tumor suppressor in non-Hodgkin´s lymphomas (NR9305)

The aim of this project is complex analysis of tumor suppressor p53 in tumor tissue of patients with diffuse large B-cell lymphoma and mantle cell lymphoma to verify whether p53 abberation is useful progno...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 2 494 tis. Kč
    • •
  • 2 494 tis. Kč
    • •
  • MZ
Project

Molecular Aspects of B-cell Receptor Signal Initiation as Targets for Specific Therapy of non-Hodgkin Lymphoma. (NV18-03-00117)

chemotherapy combination over 40 years old. The B-cell receptor (BCR) inhibition is such emerging therapy applicable to various B-cell derived NHL, which were shown to use) and “tonic” (analogous to baseline BCR s...

Oncology

  • 2018 - 2022
    • •
  • 11 156 tis. Kč
    • •
  • 11 156 tis. Kč
    • •
  • MZ
Project

Therapy intensification of patients with Diffuse Large B Cell Lymphomas based on early FDG-PET positivity (prospective analysis) and retrospective evaluation of the changes in lymphoma therapy (NR9453)

-PET evaluation in young patients with diffuse larg B-cell lymphoma with lowThe aim of the project is the analysis of different lymphoma subgroups (follicular, marginal zone, peripheral T cells) and the de...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 6 575 tis. Kč
    • •
  • 6 360 tis. Kč
    • •
  • MZ
Project

Diffuse large B-cell and follicular lymphoma - the analysis of prognostic factors and therapeutic strategies on patient´s outcome; Lymphoma Project in the Czech Republic. (NT12193)

large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in the Czech Republic will be performed on Czech Lymphoma Study Group registry cohort of approx. 4000 patients. The ultimate goal of the project ...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 6 992 tis. Kč
    • •
  • 6 864 tis. Kč
    • •
  • MZ
Project

Targeted inhibition of BCL2 family proteins in experimental therapy of diffuse large B-cell lymphoma (DLBCL) (NV15-27757A)

Diffuse large B-cell lymphoma (DLBCL) represents the most prevalent type of non-Hodgkin lymphomas (NHL) in the Western hemisphere. BCL2 and MCL1 belong to key clinically in diverse B-cell malignan...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 6 991 tis. Kč
    • •
  • 6 991 tis. Kč
    • •
  • MZ
Project

Modulation of cyclin-dependent kinases for targeted treatment of tumors with molecularly defined deregulation G1/S phase of cell cycle (GA20-25308S)

of the cell cycle (particularly the deregulation of CDK4, D-cyclins and CDKN2A in aggressive lymphomas. Inhibition of CDK4/6 makes sense in lymphomas where the type D, CDK4 amplification, or where CDKN2A deletions (mantle ...

Medicinal chemistry

  • 2020 - 2022
    • •
  • 9 640 tis. Kč
    • •
  • 9 640 tis. Kč
    • •
  • GA ČR
Project

Oncogenic properties of Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded vIRF-3 Role in pathogenesis of B-cell lymphoma (IAA501050701)

KSHV is a human herpesvirus associated with Kaposi's sarcoma, Non-Hodgkin B-cell lymphoma and Castleman's disease. The KSHV genome encodes a cluster of genes to examine whether vIRF-3 can contribute to cell growth ...

FD - Onkologie a hematologie

  • 2007 - 2010
    • •
  • 1 883 tis. Kč
    • •
  • 1 883 tis. Kč
    • •
  • AV ČR
Project

Composition of immunocompetent cells in targeted therapy in pediatric acute lymphoblastic leukemia and lymphoma (NU23-05-00353)

) in leukemia/lymphoma of B cell origin have recently become an integral part of utmost importance. Targeting specific structures on malignant B cells also influences for identification of patients with pr...

Immunology

  • 2023 - 2026
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  • 11 022 tis. Kč
    • •
  • 11 022 tis. Kč
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  • MZ
Project

The study of mech.of proto-oncog.activ.and tumor supressor genes inactiv.by fluresc.in situ hybridiz.(FISH)and compar. genomic hybridiz.(CGH)in pat.with non-Hodgkinś lymph.(NHL). (NC6209)

of chromosomal changes in mantle cell lymphoma (MCL),folicular lymphoma (FL) and diffuse large B-cell lymphoma (B-DLCL). Mapping of most frequent regions involved in changes......

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 2 582 tis. Kč
    • •
  • 2 571 tis. Kč
    • •
  • MZ
Project

Experimental therapy of mantle cell lymphoma (MCL) (NS10287)

Mantle cell lymphoma (MCL) is incurable B-cell non-Hodgkin lymphoma and thus for the therapy of mantle cell lymphoma and will provide substantiation for design of novel. We plan to evalua...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 7 079 tis. Kč
    • •
  • 7 079 tis. Kč
    • •
  • MZ
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