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1 918 (0,102s) •

Project

Identification of novel molecular pathways involved in the process of B-cell allelic exclusion; chronic lymphocytic leukemia as the model system (NS9652)

of B-lymphocytes. The process is strictly controlled and aberrant B-lymphocytes, expressing two IgVH alleles, are eliminated. Chronic lymphocytic leukemia (CLL) is a clonal disorder of B-lymp...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 8 112 tis. Kč
    • •
  • 8 082 tis. Kč
    • •
  • MZ
Project

A role of B lymphocytes in immune reactions after kidney transplantation (NT14102)

In this project, we will investigate the role of B-lymphocytes phentotypes and their transcripts in peripheral blood and the donor specific antibodies in alloimune response in the cohort of kidney transplant recipients, and in exper...

FJ - Chirurgie včetně transplantologie

  • 2013 - 2015
    • •
  • 7 609 tis. Kč
    • •
  • 7 609 tis. Kč
    • •
  • MZ
Project

Clonal analysis of antigen specific B lymphocytes from patients with rheumatoid arthritis using single-cell RT-PCR (NK7273)

Analysis of immunoglobulin genes on the mRNA level in individual citrulline specific B lymphocytes. Investigation of clonality of B cells and possible restricted usage and pairing of expressed VH and VL Ig genes. Conlusions...

FP - Ostatní lékařské obory

  • 2002 - 2004
    • •
  • 6 205 tis. Kč
    • •
  • 5 828 tis. Kč
    • •
  • MZ
Project

ROR1-positive peripheral blood b-cells of healthy donors and their connection to chronic lymphocytic leukemia development (GA23-05561S)

The project aims at description of frequency and phenotype of ROR1+ B cells to aging and chronic lymphocytic leukemia (CLL) development. So far, only immature ROR1+ B cells were described, however our data show that these p...

Cell biology

  • 2023 - 2025
    • •
  • 10 232 tis. Kč
    • •
  • 10 232 tis. Kč
    • •
  • GA ČR
Project

Characterization of B lymphocyte subpopulations in patients with common variable immunodeficiency. (NR9198)

1. Examination, quantification and more precise immunophenotypization of transitional and immature (CD21-) B cells in patients with CVID and comparison of the found transitional and immature (CD21-)B cells of CVID patients and contr...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2007 - 2009
    • •
  • 6 789 tis. Kč
    • •
  • 6 768 tis. Kč
    • •
  • MZ
Project

Lymphocyte subpopulatins in patients with humoral immunodeficiencies (NR7981)

T- and- B- cell surface markers, namely those known to be abnormal in patients with common variable immunodeficiency (CVID), will be analysed in patients with selective IgA deficiency, selective IgM deficiency and CVID. The results of T- and...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2004 - 2006
    • •
  • 1 682 tis. Kč
    • •
  • 1 668 tis. Kč
    • •
  • MZ
Project

The role of sphingosine-1-phosphate receptor 1 in B cell mechanosensitivity. (GA25-16907S)

Migrating lymphocytes encounter number of signals guiding them through tissues cues affect lymphocyte migration is unknown. We discovered that mechanical confinement triggers rapid motility of primary B cells in the absence...

Cell biology

  • 2025 - 2027
    • •
  • 11 919 tis. Kč
    • •
  • 11 919 tis. Kč
    • •
  • GA ČR
Project

Influence of Toll-like Receptor Agonists on Immunogenicity of Tumour Cells in B cell Chronic Lymphocytic Leukemia (GP310/08/P353)

B-chronic lymphocytic leukemia (B-CLL) is most frequent leukemia in adult age incurable with conventional therapy. B-CLL tumour cells are weakly immunogenic which may that enhance the immunogenicity of B-C...

EC - Imunologie

  • 2008 - 2010
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • GA ČR
Project

NON-CODING RNAS IN MICROENVIRONMENTAL INTERACTIONS OF B CELL CHRONIC LYMPHOCYTIC LEUKEMIA (GX25-15368X)

in normal and malignant B lymphocyte functions; however, the functions of long non’ role in B cell receptor (BCR) signaling and B-T cell interactions. These microenvironmental pathways are essential for normal

Cell biology

  • 2025 - 2029
    • •
  • 49 937 tis. Kč
    • •
  • 49 937 tis. Kč
    • •
  • GA ČR
Project

Analysis of clonal heterogeneity in chronic lymphocytic leukemia using next generation sequencing of B cell receptor. A national study. (NV15-30015A)

Chronic lymphocytic leukemia (CLL) is characterized by extraordinary heterogeneity concerning clinical presentation and molecular features. As the clonal disease of B lymphocytes, each case can be described by a specific im...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 15 351 tis. Kč
    • •
  • 15 028 tis. Kč
    • •
  • MZ
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