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12 (0,14s) •

Project

Targeted inhibition of BCL2 family proteins in experimental therapy of diffuse large B-cell lymphoma (DLBCL) (NV15-27757A)

-Hodgkin lymphomas (NHL) in the Western hemisphere. BCL2 and MCL1 belong to key regulators of intrinsic (mitochondrial) apoptosis. BCL2 was repeatedly associated patients. ABT-199 is a new, highly specific inhibitor of BCL2...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 6 991 tis. Kč
    • •
  • 6 991 tis. Kč
    • •
  • MZ
Project

Molecular base for therapy with BH3 mimetics to overcome refractory/relapsed Ph+ leukemias (NW24-03-00056)

on the antiapoptotic proteins BCL2 and MCL1. The efficacy of combination therapy with BCL2 and MCL1...

Oncology

  • 2024 - 2027
    • •
  • 17 555 tis. Kč
    • •
  • 16 386 tis. Kč
    • •
  • MZ
Project

Analyses of candidate genes and loci at superficial bladder tumors, prognostic value of genetic alterations in non-tumour bladder urothelium (NR8934)

The prospective study dealing with the recurrence and progression of superficial bladder cancer prediction on the basis of expression profiles of candidate genes PAX5, HSP60, BCL2 and BAX in tumour biopsies. Another aim of the study is to de...

FJ - Chirurgie včetně transplantologie

  • 2006 - 2008
    • •
  • 2 716 tis. Kč
    • •
  • 2 710 tis. Kč
    • •
  • MZ
Project

Tumor-microenvironment responsive nanomedicines as multistage drug delivery systems for experimental therapy of hematologic malignancies (GA19-01417S)

of cytotoxic drugs, inhibitors of anti-apoptotic proteins BCL2 and MCL1 (venetoclax, S63845...

Hematology

  • 2019 - 2021
    • •
  • 7 703 tis. Kč
    • •
  • 7 616 tis. Kč
    • •
  • GA ČR
Project

Polyunsaturated fatty acids and cytokines - their role in maintenance of homeostasis at the cell population level (GA524/99/0694)

, JunB, Bcl2, Bax, NF...

ED - Fyziologie

  • 1999 - 2001
    • •
  • 4 488 tis. Kč
    • •
  • 2 550 tis. Kč
    • •
  • GA ČR
Project

Role of probiotic bacteria in the regulation of intestinal epithelial cell functions (ME10017)

The major goal of this proposal is to study the role of probiotic bacterial strains Gram+ (Lactobacilli) and Gram- (non-pathogenic Escherichia coli) on the regulation of cytokine expression, signaling molecules NF-κB and p38 MAPK and apoptotic ma...

ED - Fyziologie

  • 2010 - 2012
    • •
  • 900 tis. Kč
    • •
  • 900 tis. Kč
    • •
  • MŠMT
Project

The determination of expression levels of DNA repair and cell cycle genes in peripheral blood lymphocytes in styrene exposed individuals. (IAA500390806)

In order to understand late stages in the cascade of human genotoxicity, expression levels in DNA repair (XRCC1, XPC) and cell cycle genes (p53, p21, bax, bcl2) will be addressed in styrene exposed and control populations. The intended proje...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 2 509 tis. Kč
    • •
  • 2 509 tis. Kč
    • •
  • AV ČR
Project

Biodegradable hydrogels for long-term release of cytostatics and their use in combined anticancer therapy (IAB5020201)

associated with apoptosis - p53, Bcl2, Fas-FasL, caspase 3....

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 872 tis. Kč
    • •
  • 504 tis. Kč
    • •
  • AV ČR
Project

The analysis of molecular subtypes of diffuse large B-cell lymphoma by high-resolution arrayCGH for determination of genetic changes of prognostic importance (NT11103)

and the FOXP1 gene, chromosome 8 and the CMYC gene, and chromosome 18q and the BCL2 gene. b...

FD - Onkologie a hematologie

  • 2010 - 2014
    • •
  • 6 499 tis. Kč
    • •
  • 6 479 tis. Kč
    • •
  • MZ
Project

In situ visualization of ATPase Inhibitory Factor 1 (IF1) in mitochondrial ultrastructure by high-resolution cryo-electron tomography (GA24-10325S)

with BCL2 family proteins under conditions leading to apoptosis. This project aims...

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 10 049 tis. Kč
    • •
  • 10 049 tis. Kč
    • •
  • GA ČR
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