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9 (0,124s) •

Project

Mechanistic insight into the eIF4F contribution to the development of melanoma resistance to clinical BRAF and MEK inhibitors (GA25-17766S)

Oncogenic mutations in NRAS and BRAF constitutively activate the ERK MAPK pathway in melanoma cells, fueling aggressive tumor growth and making the ERK BRAF and MEK kinase inhibitors often develops during treatment. While in the eme...

Cell biology

  • 2025 - 2027
    • •
  • 9 805 tis. Kč
    • •
  • 9 805 tis. Kč
    • •
  • GA ČR
Project

New molecular mechanisms in the dynamic control of the ERK pathway in melanoma as potential therapeutic targets (GA22-30397S)

Oncogenic NRAS and BRAF mutations, constitutively activating the ERK pathway, are known drivers of the aggressive growth of malignant melanoma, and the ERK signaling is a prime therapeutic target. BRAF and MEK inhibitors can delay t...

Cell biology

  • 2022 - 2024
    • •
  • 7 946 tis. Kč
    • •
  • 7 946 tis. Kč
    • •
  • GA ČR
Project

Molecular characteristics of borderline ovarian tumors in relation to their biological behavior (NS10566)

(genetic and epigenetic) changes ? mutations of oncogenes KRAS and BRAF, loss...

FK - Gynekologie a porodnictví

  • 2009 - 2011
    • •
  • 4 935 tis. Kč
    • •
  • 4 815 tis. Kč
    • •
  • MZ
Project

Main genetic causes and their modifiers in the pathogenesis of thyroid cancer (NR9165)

1) To find the role of polymorphisms within RET proto-oncogene as modifying factors in the pathogenesis of medullary thyroid carcinoma and papillary thyroid carcinoma. To compare the frequencies with healthy controls. 2) To detect main genetic causes...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 4 936 tis. Kč
    • •
  • 4 891 tis. Kč
    • •
  • MZ
Project

The impact of WT1 gene and other molecular-biologic abnormalities as potential prognostic and predictive factors in testicular germ-cell tumors (NT12414)

clinical implication like BRAF and PT53 mutations to demonstrate if any of them could...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 7 734 tis. Kč
    • •
  • 7 734 tis. Kč
    • •
  • MZ
Project

Study of the Genetic Alterations in Thyroid Cancer (NT13901)

The main project purpose is to study the influence of gene variants in 18 candidate genes on the pathogenesis of thyroid cancer using our large cohorts. Moreover, we will continue in correlation of the main genetic alterations (RET, BRAF, RE...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2015
    • •
  • 9 752 tis. Kč
    • •
  • 9 752 tis. Kč
    • •
  • MZ
Project

The development of new microsatellite instability diagnostic tests for therapeutic and prognostic purposes in oncology (TH04010095)

of 1.part of the project. The test combines mut. analyses of MMR and a BRAF genes...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2019 - 2022
    • •
  • 14 581 tis. Kč
    • •
  • 8 533 tis. Kč
    • •
  • TA ČR
Project

Thyroid cancer in children and adolescents and its molecular genetic background (NV16-32665A)

in thyroid cancer in adult patients (BRAF, RAS, RET, TERT etc. genes), but also...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2016 - 2019
    • •
  • 13 430 tis. Kč
    • •
  • 13 430 tis. Kč
    • •
  • MZ
Project

Electrochemical biosensor for analysis of DNA point mutations in colorectal cancer (NU21-08-00078)

Colorectal cancer (CRC) is one of the most frequent oncological diseases worldwide with rising incidence. Point mutations in certain genes, such as KRAS, BRAF, EGFR or TP53, are one of the key factors in tumor formation, and thus their analy...

Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

  • 2021 - 2024
    • •
  • 7 649 tis. Kč
    • •
  • 7 649 tis. Kč
    • •
  • MZ
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