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441 (0,089s) •

Project

Testing of the Anti-Arrhythmic Effects of Potential Drugs From The Group of Ultra-short-Acting Blockers of Adrenergic Receptors (NR9126)

Antiarrhytmic agents from the beta blocker group have the lowest arrhytmogenic effect and are thus most requested in the clinical practice. The compounds that we are testing belong to the group of ultra-short acting beta ad...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 1 165 tis. Kč
    • •
  • 1 165 tis. Kč
    • •
  • MZ
Project

Significance of mitochondrial uncoupling in pancreatic beta cells for development of type-2 diabetes. (NR7917)

is to find blockers of the pathologically enhanced uncoupling of beta cell mitochondriaWe'll study mitochondrial uncoupling of pancreatic beta-cells due to enhanced expression/function of uncoupling protein UCP2 &other gen...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2009
    • •
  • 12 765 tis. Kč
    • •
  • 8 453 tis. Kč
    • •
  • MZ
Project

Small protein blockers of IL-23/IL-17 axis as intestinal inflammation inhibitors secreted by probiotic bacteria. (GF21-16423K)

lactis secreting small protein blockers of key members of Th17 cell-mediated pro of experimental colitis. To this goal we will use L. lactis secreting blockers of IL-23 cytokine (ILP binders), blockers of IL-23 receptor (R...

Health-related biotechnology

  • 2021 - 2024
    • •
  • 11 238 tis. Kč
    • •
  • 11 238 tis. Kč
    • •
  • GA ČR
Project

Novel open-channel blockers of NMDA receptors with enhanced membrane-to-channel inhibition (GA24-10026S)

N-methyl-D-aspartate receptors (NMDARs) are essential for developing many central nervous system diseases. Although approved blockers acting at NMDARs are available, including memantine and ketamine, a high demand exists for developing poten...

Medicinal chemistry

  • 2024 - 2026
    • •
  • 12 027 tis. Kč
    • •
  • 12 027 tis. Kč
    • •
  • GA ČR
Project

Heart arrest by the use of esmolol under normothermic perfusion during ECC. Comparison with crystaloid and blood cardioplegia. (NA5059)

Heart arrest using B-blockers without crossclamping of ascending aorta....

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1998 - 2000
    • •
  • 2 471 tis. Kč
    • •
  • 2 394 tis. Kč
    • •
  • MZ
Project

Analysis of metabolic effects of telmisartan mediated by selective; PPARgamma modulation (GAP303/10/0505)

The tacit assumption that underlies the interpretation of most studies involving angiotensin receptor blockers (ARBs) is that these molecules interact only with the AT1 receptor and that therefore: 1) most if not all of their biologic proper...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2010 - 2013
    • •
  • 6 768 tis. Kč
    • •
  • 6 768 tis. Kč
    • •
  • GA ČR
Project

Therapy of convulsive status epilepticus - experimental and clinical study (NL5745)

Pilocarpina-induced status epilepticus in rats will be treated either clasically (clonazepam or thiopental anesthesia) or experimentally (antagonists of excitatory aminoacid receptors or calcium channel blockers). Spontaneous recurrent seizu...

FR - Farmakologie a lékárnická chemie

  • 1999 - 2001
    • •
  • 1 255 tis. Kč
    • •
  • 1 252 tis. Kč
    • •
  • MZ
Project

Consulting Center for Identification and Epidemiology of Beta-Lactamases Produced by Gram-Negative Bacteria (2E08003)

of clinical important beta-lactamases (ESBL, AmpC, MBL) in clinical microbiology to effective tretament of infections caused by beta-lactamase-producing Gram-negative bacteria. During the project, diagnosing the diversity of clinic...

EE - Mikrobiologie, virologie

  • 2008 - 2009
    • •
  • 3 382 tis. Kč
    • •
  • 3 290 tis. Kč
    • •
  • MŠMT
Project

Machine development with modular equipment for complex processing of wood mass - AXER PROFESIONAL (EG17_175/0015584)

The project is focused on research and development of machines and additional equipment for complex processing of wood or biomass. This device will be based on the existing AXER product platform. In addition to the wood splitting machine itself, the ...

Electrical and electronic engineering

  • 2019 - 2023
    • •
  • 5 600 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MPO
Project

Study of beta -glucans of particular edible mushrooms (GA525/05/0273)

contain besides chitin and other polysaccharides - beta-glucans. Beta-glucans from. The structural features of beta-glucans are important determinants of their physical properties and functionality. In frame of the proposa...

GM - Potravinářství

  • 2005 - 2007
    • •
  • 2 393 tis. Kč
    • •
  • 2 393 tis. Kč
    • •
  • GA ČR
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